Nutrient absorption

Nutting, David F.; Kumar, Neelesh; Hilaire, R. James St.; Mansbach, Charles M.

doi:10.1097/00075197-199909000-00010

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…Many past reviews have been written on the digestion and absorption of lipid and the formation of chylomicrons by the small intestine (1,2,3,4). This review will update our current knowledge on the digestion, uptake, and transport of dietary lipid.…”

Section: Introductionmentioning

confidence: 99%

Intestinal lipid absorption and transport

Phan¹

2001

Front Biosci

156

117

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Introduction 3. Dietary lipids 4. Structured lipids 5. Digestion of dietary lipids and structured lipids 5.1. Gastric lumen 5.2. Intestinal lumen 5.3. Digestion of phospholipid 5.4. Digestion of cholesteryl ester 6. Uptake of dietary lipids by enterocytes 6.1. Importance of micellar solubilization 6.2. Importance of unilamellar vesicles 6.3. Uptake of fat digestion products by enterocytes 7. Resynthesis of triglycerides and formation of chylomicrons 7.1. Monoglycerides and fatty acid 7.2. Phospholipids 7.3. Cholesterol 8. Assembly of intestinal lipoproteins 9. Clinical disorders of intestinal lipid transport 10. Acknowledgements 11. References

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Section: Introductionmentioning

confidence: 99%

Intestinal lipid absorption and transport

Phan¹

2001

Front Biosci

156

117

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Intestinal lipid absorption and transport

Phan

Tso²

2001

Front Biosci

166

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The purpose of this review is to update the reader on our current knowledge of the digestion, uptake, and transport of dietary lipid. In particular, it discusses how intestinal lipid transporters may play a role in the uptake of lipids by the enterocytes, and how chylomicrons are formed in the enterocytes and packaged for export into the lymphatic system through exocytosis. The classification and properties of lipids is first described followed by a discussion of structured lipids and their role in human nutrition. Digestion of triacylglycerols takes place in the stomach aided by the enzyme gastric lipase. The origin and properties of lingual and gastric lipase are reviewed. Most digestion of triacylglycerols by pancreatic lipase occurs in the intestinal lumen. Similarly, digestion of cholesteryl ester and phospholipids also takes place in the intestinal lumen. This review describes in considerable detail the uptake of lipid digestion products by the enterocytes, particularly the role of recently identified lipid transporters. The intracellular trafficking and the resynthesis of complex lipids from the lipid digestion products are talked about, particularly within the context of the recently generated knockout mouse that lacks the key lipid reesterification enzymes. Finally, the mechanisms of the formation and secretion of chylomicrons is described and clinical disorders discussed.

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“…5 Intestinal mucosa contains leptin receptors, and it was postulated that direct leptin signaling in the intestine might be involved in the regulation of nutrient absorption and intestinal motility. 6,7 Furthermore, leptin is involved in immune regulation. 8 As a disease with intestinal histopathologic alterations due to immune mechanisms, and subsequent malnutrition and/or growth failure, CD deserves interest regarding leptin status.…”

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confidence: 99%