Nutrient composition and ameliorative effects of Cocos nucifera products on Alloxan-induced diabetic wistar rats

Augustine, Benjamin; Charity, Ogunka-Nnoka; Amadi, Peter Uchenna; Miebaka, Ogaji

doi:10.14419/ijm.v5i2.7647

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…ABTS radical scavenging potentials of garden egg stalk.While the Fe 3+ , superoxide, and lipid peroxide scavenging potentials of the eggplant stalk as shown in Figures 5, 6, and 7, respectively, were equivalent to the standards used.The significant DPPH and ABTS scavenging potentials of eggplant stalk shown in this study, testifies to the potent hydrogen donating capacities of their phytoconstituents, and in addition, their nitric acid and hydrogen peroxide scavenging potentials directly implicate rich supplies of phenolic acids in the eggplant stalk(Aluko et al, 2013).…”

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confidence: 63%

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Nutritional profiling of garden egg stalk Solanum macrocarpum L. (Solanales: Solanaceae)

Ogunka-Nnoka¹,

Ekrika²

2018

Braz. J. Biol. Sci.

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This study was carried out to evaluate the nutritional properties of Solanum macrocarpum L. (Solanales: Solanaceae) (garden egg) stalk using standard methods. Sulphates and chloride were the most abundant anions while calcium and magnesium were the predominant mineral cations. Results for the proximate composition showed high carbohydrates (27.70%), fibre contents (22.94%), and ash (18.83%) while the phytochemical composition showed higher ribalinidine, catechin, and phenol contents. Vitamin B 6 , C, A, and B 12 were found in higher concentrations, while lysine (9.48 g/100 g), phenylalanine (6.86 g/100 g), leucine (6.59 g/100 g), and arginine (5.66 g/100 g) were the predominant essential amino acids. Results for the free radical scavenging potentials showed higher DPPH, nitric oxide, hydrogen peroxide, and ABTS radical scavenging potentials for the garden egg stalk, while their ferric reducing antioxidant power, superoxide and lipid peroxide scavenging were comparable to the standards used. This study has shown the high nutrient density of the garden egg stalk, thus encouraging its inclusion for dietary uses.

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confidence: 63%

“…According to Ali (2009), food materials providing above 12% of proteins can be regarded as sufficient protein sources. This implies that the eggplant stalk is a sufficient protein source.…”

Section: Resultsmentioning

confidence: 99%

Nutritional profiling of garden egg stalk Solanum macrocarpum L. (Solanales: Solanaceae)

Ogunka-Nnoka¹,

Ekrika²

2018

Braz. J. Biol. Sci.

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“…A hundred grams (100g) of the sliced coconut meat was blended in 200ml of distilled water using an electric blender. Thereafter, the ground mixture was sieved with cotton sieve, and the filtrate (CM) was used in the experiment (Benjamin et al, 2017;Dosumu et al, 2021). The extract was freshly prepared for every day of diet preparation throughout the experiment.…”

Section: Preparation Of Coconut Milkmentioning

confidence: 99%

Coconut milk ameliorates motor and non-motor deficits in the alpha-synuclein transgenic Drosophila melanogaster model for Parkinsonism

Idowu¹

2022

SLUJST

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Context: Parkinson's disease (PD) is a multisystem neurodegenerative disorder associated with oxidative stress and disrupted mitochondrial function. It is characterized by motor and non-motor symptoms due to multi-factors. Coconut (Cocos nucifera) milk contains a complex mixture of highly nutritional constituents such as carbohydrates, vitamins and minerals which have remarkable health benefits. Lauric acid (LA) which makes up to 54.5% of total nutrient composition of coconut milk (CM) possesses strong antioxidant properties. Objectives: This study evaluated the effect of CM on PD-associated motor and non-motor deficits in alpha-synuclein (α-syn) transgenic Drosophila melanogaster (D. melanogaster). Methods: W1118 strain (control) and α-syn transgenic (PD strain) of D. melanogaster aged between 1 to 3 days were randomized into various groups. The control flies were fed on untreated diets, while the PD flies were orally exposed to varied concentrations (0, 5, 10 and 15% v/v) of coconut milk diet for 14 days. Subsequently, longevity, behavioral, fecundity and biochemical analyses were conducted across the groups. Results: The results showed that CM significantly increased longevity, climbing ability, egg count and the rate of emergence (P< 0.05). In addition, MDA and NO levels as well as AChE activity were significantly decreased, while GSH level alongside SOD and CAT activities were increased (P< 0.05) in the CM-treated PD flies in a concentration-dependent manner. Conclusions: CM ameliorated PD-associated deficits in D. melanogaster by prolonging lifespan, improving locomotor function, fecundity and redox status.

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Toxicities of selected medicinal plants and floras of lower phyla

Amadi

Agomuo

Agada

et al. 2018

Alexandria Journal of Medicine

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The aim of this study was to evaluate the toxic effects associated with the administration of aqueous extracts (AE) of Calliandra portoricensis (CP), Dracaena arborea (DA), Duranta repens (DR), Polytrichum juniperinum (PJ), Parmelia caperata (PC), and Nostartium officinale (NO) on Wistar rats. LD 50 for each plant was obtained prior to administration. Seven groups of six rats each were orally gavaged for 28 days as follows; group 1-7 received normal rat pellets and saline, in addition, group 2 received 20 mg/kg b.w CP, group 3 & 4 respectively received 8 mg/kg b.w DA and DR, group 5 & 6 respectively received 4 mg/ kg b.w PJ and PC, and group 7 received 100 mg/kg b.w NO. Liver enzymes; ALP, ALT, AST and GGT were significantly (p < 0.05) elevated by CP, DR, PJ and PC extracts. All the extracts caused significant alterations of the total protein, albumin and globulin levels. The urea levels were deranged by all the extracts while CP, PJ, PC, and NO extracts caused no significant effects on the creatinine levels. Both DR and NO deranged the serum electrolytes; Na, K, Cl, and HCO 3. Results for the lipid profile showed that all extracts significantly altered the phosphatidate phosphohydrolase and LDL levels while no significant effects were observed in the VLDL, TG, TC, HDL, cardiac risk ratio, arterogenic coefficients, and arterogenic index of plasma, of NO treated rats. For hematological parameters DR, PJ, and PC significantly deranged the RBC, HGB, MCHC, MCV, and MCH concentrations while the neutrophils, eosinophils and basophils were significantly altered on administration of all the extracts. No significant effects were observed on the platelets and plateletcrit level in rats gavaged with CP, whereas the MPV, PDW, and PCT concentrations were deranged by DR extracts. CP and NO caused no alterations in the MDA, GSH, and GST levels whereas the SOD, GPx, and xanthine oxidase levels were significantly deranged by all the plant extracts. Only NO treatment produced catalase, glutathione reductase, and xanthine dehydrogenase levels equivalent to the control group. This study has shown various degrees of deleterious effects on biochemical parameters associated with the consumption of these plants, thus raising serious concerns over their continuous applications as local medicaments.

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Nutrient composition and ameliorative effects of Cocos nucifera products on Alloxan-induced diabetic wistar rats

Cited by 3 publications

References 43 publications

Nutritional profiling of garden egg stalk Solanum macrocarpum L. (Solanales: Solanaceae)

Nutritional profiling of garden egg stalk Solanum macrocarpum L. (Solanales: Solanaceae)

Coconut milk ameliorates motor and non-motor deficits in the alpha-synuclein transgenic Drosophila melanogaster model for Parkinsonism

Toxicities of selected medicinal plants and floras of lower phyla

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