Nutrient effects on working memory across the adult lifespan

Cansino, Selene; Torres-Trejo, Frine; Estrada-Manilla, Cinthya; Flores-Mendoza, Adriana; Ramírez-Pérez, Gerardo; Ruíz-Velasco, Silvia

doi:10.1080/1028415x.2022.2055378

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…We also evaluated the adequacy of other nutrients that are involved in choline metabolism (vitamin B12, B6, folate, methionine, cysteine), but did not identify any deficiencies or associations between these nutrients and working memory performance in the present sample. There are, however, several other nutrients that have been positively associated with working memory in adults (eg, cholesterol, alcohol, vitamin E, palmitoleic acid, oleic acid, alpha-linoleic acid, linoleic acid, vitamin C, vitamin D) [ 64 ], and many are provided in the medical foods and dietary supplements regularly consumed by individuals with PKU. Future research, which systematically examines the additive effect of choline with other neurologically relevant nutrients on working memory and associated cardiometabolic risk factors may improve the formulation and efficacy of these products.…”

Section: Discussionmentioning

confidence: 99%

Total choline intake and working memory performance in adults with phenylketonuria

Schoen

Boland

Christ

et al. 2023

Orphanet J Rare Dis

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Background Despite early diagnosis and compliance with phenylalanine (Phe)-restricted diets, many individuals with phenylketonuria (PKU) still exhibit neurological changes and experience deficits in working memory and other executive functions. Suboptimal choline intake may contribute to these impairments, but this relationship has not been previously investigated in PKU. The objective of this study was to determine if choline intake is correlated with working memory performance, and if this relationship is modified by diagnosis and metabolic control. Methods This was a cross-sectional study that included 40 adults with PKU and 40 demographically matched healthy adults. Web-based neurocognitive tests were used to assess working memory performance and 3-day dietary records were collected to evaluate nutrient intake. Recent and historical blood Phe concentrations were collected as measures of metabolic control. Results Working memory performance was 0.32 z-scores (95% CI 0.06, 0.58) lower, on average, in participants with PKU compared to participants without PKU, and this difference was not modified by total choline intake (F[1,75] = 0.85, p = 0.36). However, in a subgroup with complete historical blood Phe data, increased total choline intake was related to improved working memory outcomes among participants with well controlled PKU (Phe = 360 µmol/L) after adjusting for intellectual ability and mid-childhood Phe concentrations (average change in working memory per 100 mg change in choline = 0.11; 95% CI 0.02, 0.20; p = 0.02). There also was a trend, albeit nonsignificant (p = 0.10), for this association to be attenuated with increased Phe concentrations. Conclusions Clinical monitoring of choline intake is essential for all individuals with PKU but may have important implications for working memory functioning among patients with good metabolic control. Results from this study should be confirmed in a larger controlled trial in people living with PKU.

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Section: Discussionmentioning

confidence: 99%

Total choline intake and working memory performance in adults with phenylketonuria

Schoen

Boland

Christ

et al. 2023

Orphanet J Rare Dis

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Binary classification of pumpkin (Cucurbita pepo L.) seeds based on quality features using machine learning algorithms

Çetin,

Ropelewska,

Fidan

et al. 2023

Eur Food Res Technol

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Does habitual moderate alcohol consumption enhance working memory performance?

Cansino,

Torres-Trejo,

Estrada-Manilla

et al. 2023

Curr Psychol

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The present study aimed to establish whether habitual alcohol consumption benefits verbal and spatial working memory performance after addressing the main criticisms that have been raised against the finding that alcohol benefits cognition. An adult lifespan sample of 1,652 healthy adults between 21 and 80 years of age participated in the study. Participants were classified as lifetime nondrinkers or drinkers, and several demographic and biological variables were controlled. Alcohol consumption was assessed through a lifestyle questionnaire created for the study. Working memory was measured through a 2-back computerized task. Discrimination and speed in verbal and spatial working memory among drinkers were superior to those among nondrinkers. Total alcohol intake across life and the amount of alcohol intake per week predicted higher verbal and spatial working memory discrimination. Beer drinkers showed more accurate and faster responses in verbal and spatial working memory than nondrinkers, wine drinkers and spirit drinkers. The optimal amount of alcohol intake to benefit working memory for women and men was 100 g per week, which is equivalent to one drink per day. After consuming 350 g of alcohol per week, equivalent to 25 drinks per week, the effects of alcohol on working memory become more negative than the effects of alcohol abstinence. While alcohol consumption is considered a risk factor for several diseases, we found that moderate alcohol intake benefits working memory performance throughout the adult lifespan to a greater extent than whole-life abstinence.

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Nutrient effects on working memory across the adult lifespan

Cited by 3 publications

References 48 publications

Total choline intake and working memory performance in adults with phenylketonuria

Total choline intake and working memory performance in adults with phenylketonuria

Binary classification of pumpkin (Cucurbita pepo L.) seeds based on quality features using machine learning algorithms

Does habitual moderate alcohol consumption enhance working memory performance?

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