Nutrient intake patterns and breast cancer risk among Jordanian women: a case-control study

Tayyem, Reema; Mahmoud, Reema; Shareef, Muna H.; Marei, Lina

doi:10.4178/epih.e2019010

Cited by 15 publications

(7 citation statements)

References 32 publications

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“…The antitumour effect of vitamin D is a popular research topic. Epidemiological studies have compared the relationship between serum vitamin D levels and prognosis in patients with breast cancer 25 and rectal cancer 26 and have found that the higher the serum level of vitamin D is, the better is patient prognosis. The regulatory relationship between vitamin D and tumours has not yet been elucidated, and its mechanism has not been clarified.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3

Huang

Zhang

et al. 2019

Cell Death Dis

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Chemoresistance is a major cause of cancer progression and the mortality of cancer patients. Developing a safe strategy for enhancing chemosensitivity is a challenge for biomedical science. Recent studies have suggested that vitamin D supplementation may decrease the risk of many cancers. However, the role of vitamin D in chemotherapy remains unknown. We found that vitamin D sensitised oral cancer cells to cisplatin and partially reversed cisplatin resistance. Using RNA-seq, we discovered that lipocalin 2 (LCN2) is an important mediator. Cisplatin enhanced the expression of LCN2 by decreasing methylation at the promoter, whereas vitamin D enhanced methylation and thereby inhibited the expression of LCN2. Overexpression of LCN2 increased cell survival and cisplatin resistance both in vitro and in vivo. High LCN2 expression was positively associated with differentiation, lymph node metastasis, and T staging and predicted a poor prognosis in oral squamous cell carcinoma (OSCC) patients. LCN2 was also associated with post-chemotherapy recurrence. Moreover, we found that LCN2 promoted the activation of NF-κB by binding to ribosomal protein S3 (RPS3) and enhanced the interaction between RPS3 and p65. Our study reveals that vitamin D can enhance cisplatin chemotherapy and suggests that vitamin D should be supplied during chemotherapy; however, more follow-up clinical studies are needed.

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Section: Discussionmentioning

confidence: 99%

Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3

Huang

Zhang

et al. 2019

Cell Death Dis

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“…This diet is high in dietary ber, calcium, folate, carotenes and phenolic compounds [39]. The association of these nutrients with BC risk has been suggested in several studies [40][41][42][43]. Furthermore, this dietary pattern is high in dietary antioxidants such as proanthocyanidines, avonoids, stilbenes and alpha-tocopherols [44,39] which could reduce cancer risk [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Adherence to the DASH Diet and Risk of Breast Cancer

Toorang

Sasanfar

Esmaillzadeh

et al. 2022

Clinical Breast Cancer

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Background: The Dietary Approach to Stop Hypertension (DASH) eating pattern has been recommended as a healthy dietary plan by several international guidelines. However, data on the association between the DASH diet and breast cancer (BC) is limited. This study investigated the association between the DASH dietary pattern and risk of BC.Methods: This is a hospital-based case-control study conducted between 2014 and 2016 in the Cancer Institute of Iran. Patients with histopathologically con rmed BC were recruited. Controls were healthy subjects who were frequency matched to cases by residential place and age (±10years). A validated 168-item Food Frequency Questionnaire (FFQ) was applied to assess the dietary intake of participants. Physical activity was assessed using the Global Physical Activity Questionnaire (GPAQ). The DASH dietary pattern scores were calculated using the method introduced by Fung. Unconditional logistic regression, in which potential confounders were taken into account, was applied to determine the association between adherence to the DASH dietary pattern and odds of BC.Results: The study participants comprised 477 patients with BC and 507 healthy controls. In the total population, patients with BC were slightly older (45.9 vs. 43.9 y, P=0.02), had slightly higher BMI (21.9 vs. 20.2, P=0.01) and were less physically active (20 vs. 27 MET h/wk. P<0.01) than controls. In Model A, which was adjusted for age and energy intake, adherence to the DASH dietary pattern substantially reduced BC risk in the total population (OR for comparing extreme tertiles: 0.62; 95% CI 0.44-0.78; P trend =0.004). Even after controlling for more cofounders, greatest adherence to DASH diet was associated with a 34% reduction in risk of BC (OR 0.66; 95% CI 0.46, 0.94; P trend =0.03). In premenopausal women, adherence to the DASH dietary pattern was insigni cantly associated with a 32% reduction in BC risk. This risk reduction was 38% in postmenopausal women, which was also not found to be signi cant Conclusion: Adherence to the DASH dietary pattern could be associated with an approximately 30% reduction in risk of BC. However, further studies, in particular studies with prospective design, are required to con rm this claim.

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“…Table 1 shows participants' socio-demographic, anthropometric measurements, health and lifestyle characteristics. 15 Average age for cases was 48.9±0.63 years and 47.5±0.59 years for control. BMI, education level, employment status, smoking and family history of BC, were all significantly different as BC cases compared to the controls.…”

Section: Resultsmentioning

confidence: 95%

The Intake of Some Nutrients is Associated with the Risk of Breast Cancer: Results from Jordanian Case-Control Study

Tayyem

Mahmoud

Marei

2020

Curr Res Nutr Food Sci

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Breast cancer (BC) is the most commonly diagnosed cancer and is considered the leading cause of cancer deaths in women globally. The aim of this study is to evaluate the relationship between macro- and micronutrient intake and BC risk among Jordanian women. A case-control design was used in this study, and BC patients were recruited from the main two hospitals provide cancer therapy in Jordan. Four hundred women aged 20-65 years of age were enrolled in the study. For the cases, 200 recently diagnosed BC women were selected from the two hospitals and matched in age and marital status to 200 BC-free women. Dietary data were collected through face-to-face interview using a validated food frequency questionnaire between October 2016 and September 2017. To calculate odds ratio (OR), logistic regression was used; while for p-trend the linear regression was performed. The study results demonstrated that increasing the intake of total energy and percentage of fat was significantly and positively associated with BC (p-= 0.001). The risk of BC increased significantly and positively as carbohydrate, sugar, fat, saturated fat and polyunsaturated and monounsaturated fatty acids intake increased. A significant trend in BC risk was found for cholesterol (p-= 0.005). The ORs for higher intakes of vitamins E, B1, B2, and B3, folate and phosphorus showed a significant association with the risk of BC (p-trend =0.001). A significant inverse effect was detected between iron intake and BC risk (p-=0.001). The study findings resulted in insight of the associations between the total energy intake and some macro/micronutrients intake can be an increasing risk of BC.

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Nutrient intake patterns and breast cancer risk among Jordanian women: a case-control study

Cited by 15 publications

References 32 publications

Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3

Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3

Adherence to the DASH Diet and Risk of Breast Cancer

The Intake of Some Nutrients is Associated with the Risk of Breast Cancer: Results from Jordanian Case-Control Study

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