Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss

Rosen, Clifford J

doi:10.1038/s41574-023-00879-4

Cited by 7 publications

(1 citation statement)

References 106 publications

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“…BMAT has been described as a highly dynamic fat depot that responds to dietary changes, but it has distinct characteristics compared with extramedullary fat, both from a biological and regulatory perspective 56 . For instance, and surprisingly, both nutrient deprivation (e.g.…”

Section: Discussionmentioning

confidence: 99%

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Alonso-Calleja,

Perino,

Schyrr

et al. 2023

Preprint

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The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged as powerful signaling molecules that act as a relay between the digestive system, the microbiota and the rest of the body. The signaling function of BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects in immune cells, but its effect on the BM as a primary immune organ remains unknown. Here, we investigated the BM of young mice and observed a significant reduction in bone marrow adipose tissue (BMAT) upon loss of TGR5, accompanied by an enrichment in BM adipocyte progenitors which translated into enhanced hematopoietic recovery upon transplantation. These findings open the possibility of modulating stromal hematopoietic support by acting on TGR5 signaling.SummaryThis work shows that TGR5 loss-of-function reduces regulated bone marrow adipose tissue and accelerates recovery upon bone marrow transplantation. These data highlight TGR5 as key player of the bone marrow microenvironment.

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Section: Discussionmentioning

confidence: 99%