Nutriepigenomics in Environmental-Associated Oxidative Stress

Rubio, Karla; Hernández-Cruz, Estefani Yaquelin; Rogel-Ayala, Diana G.; Sarvari, Pouya; Isidoro, Ciro; Barreto, Guillermo; Pedraza-Chaverri, José

doi:10.3390/antiox12030771

Cited by 8 publications

(2 citation statements)

References 280 publications

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“…The field of environmental epigenetics research has experienced a revolution due to the discovery of various ncRNA species, transforming our understanding of physiology and disease development ( Frye et al, 2021 ; Olmedo-Suárez et al, 2022 ; Rubio et al, 2023a ). ncRNAs, including miRNAs, piRNAs, and lncRNAs, play roles in biological processes by interacting with transcription factors and key regulatory proteins ( Mattick et al, 2023 ).…”

Section: General Characteristics Of Particulate Matter Subtypesmentioning

confidence: 99%

Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health

Gavito-Covarrubias,

Ramírez-Díaz,

Guzmán-Linares

et al. 2024

Front. Genet.

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Environmental pollution nowadays has not only a direct correlation with human health changes but a direct social impact. Epidemiological studies have evidenced the increased damage to human health on a daily basis because of damage to the ecological niche. Rapid urban growth and industrialized societies importantly compromise air quality, which can be assessed by a notable accumulation of air pollutants in both the gas and the particle phases. Of them, particulate matter (PM) represents a highly complex mixture of organic and inorganic compounds of the most variable size, composition, and origin. PM being one of the most complex environmental pollutants, its accumulation also varies in a temporal and spatial manner, which challenges current analytical techniques used to investigate PM interactions. Nevertheless, the characterization of the chemical composition of PM is a reliable indicator of the composition of the atmosphere, the quality of breathed air in urbanized societies, industrial zones and consequently gives support for pertinent measures to avoid serious health damage. Epigenomic damage is one of the most promising biological mechanisms of air pollution-derived carcinogenesis. Therefore, this review aims to highlight the implication of PM exposure in diverse molecular mechanisms driving human diseases by altered epigenetic regulation. The presented findings in the context of pan-organic cancer, fibrosis, neurodegeneration and metabolic diseases may provide valuable insights into the toxicity effects of PM components at the epigenomic level and may serve as biomarkers of early detection for novel targeted therapies.

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Section: General Characteristics Of Particulate Matter Subtypesmentioning

confidence: 99%

Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health

Gavito-Covarrubias,

Ramírez-Díaz,

Guzmán-Linares

et al. 2024

Front. Genet.

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“…А дієтичне споживання таких сполук може сприяти здоров'ю і продовжувати тривалість життя за допомогою численних механізмів, включаючи зниження окисного стресу, індукцію аутофагії і пригнічення запалення (активації NLRP3). Інфламасома NLRP3 є мультибілковим комплексом, який відіграє ключову роль у регуляції вродженої імунної системи та передачі сигналів запалення) [43][44][45][46].…”

Section: аутофагія в умовах обмеження калорійunclassified

Biomedical significance of the therapeutic use of autophagy (literature review)

Sribna

2024

ECM

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Autophagy, or is an intracellular degradation pathway for improperly functioning aggre-gation-prone proteins, damaged organelles, unwanted macromolecules, and invading patho-gens. The process is necessary for maintaining cell and tissue homeostasis, which contributes to the survival of the organism, and is actively studied. The purpose of this work was the search, selection and analysis of the literature on autophagy as one of the main mechanisms of maintaining cellular homeostasis under conditions of oxidative stress; cellular aging; calo-rie restriction; as well as about the targeted effect on autophagy in the conditions of various diseases. The following generalizations were made: 1) the ability to be directly activated in response to the intense formation of reactive oxygen species in cells allows us to consider autophagy as an important element of antioxidant protection, therefore, the study of ways and means of effective autophagy management is becoming relevant today; 2) dietary con-sumption of autophagy activators may promote health and extend lifespan through multiple mechanisms, including reduction of oxidative stress, induction of autophagy, and suppression of inflammation; 3) studies aimed at elucidating the role of sirtuins, which are key regulators of cellular metabolism and oxidative stress, are gaining relevance in the initiation of autoph-agy. Currently, sirtuin-dependent mechanisms of autophagy require research in experimental models using mammalian cells; 4) continuing the study of autophagy processes will allow a better understanding of physiological aspects and help ensure progress in the development of new strategies for the prevention and treatment of human diseases (including those related to age); 5) autophagy is crucial for cellular physiology, autophagy dysfunction is in-volved in the pathogenesis of various human diseases, and therefore the therapeutic use of autophagy has potential biomedical significance. Keywords: cell death, cellular homeostasis, oxidative stress, cellular aging, calorie restriction, targeted effect on autophagy.

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