Nutrigenetics: links between genetic background and response to Mediterranean-type diets

Lairon, Denis; Defoort, Catherine; Martin, Jean-Charles; Amiot, Marie-Josèphe; Gastaldi, Marguerite; Planells, Richard

doi:10.1017/s1368980009990437

Cited by 26 publications

(17 citation statements)

References 20 publications

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“…Although poor dietary habits can be detrimental to health by themselves, the numerous interactions between nutrients and genes can further modulate an individual's risk for developing disease [18]. The determinants of plasma lipids are multi-factorial; however, it remains unclear to what extent genetic variability contributes to the inter-individual differences observed in plasma lipid profiles.…”

Section: Introductionmentioning

confidence: 99%

Genetic variation in lipid desaturases and its impact on the development of human disease

2010

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Perturbations in lipid metabolism characterize many of the chronic diseases currently plaguing our society, such as obesity, diabetes, and cardiovascular disease. Thus interventions that target plasma lipid levels remain a primary goal to manage these diseases. The determinants of plasma lipid levels are multi-factorial, consisting of both genetic and lifestyle components. Recent evidence indicates that fatty acid desaturases have an important role in defining plasma and tissue lipid profiles. This review will highlight the current state-of-knowledge regarding three desaturases (Scd-1, Fads1 and Fads2) and their potential roles in disease onset and development. Although research in rodent models has provided invaluable insight into the regulation and functions of these desaturases, the extent to which murine research can be translated to humans remains unclear. Evidence emerging from human-based research demonstrates that genetic variation in human desaturase genes affects enzyme activity and, consequently, disease risk factors. Moreover, this genetic variation may have a trans-generational effect via breastfeeding. Therefore inter-individual variation in desaturase function is attributed to both genetic and lifestyle components. As such, population-based research regarding the role of desaturases on disease risk is challenged by this complex gene-lifestyle paradigm. Unravelling the contribution of each component is paramount for understanding the inter-individual variation that exists in plasma lipid profiles, and will provide crucial information to develop personalized strategies to improve health management.

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Section: Introductionmentioning

confidence: 99%

Genetic variation in lipid desaturases and its impact on the development of human disease

2010

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“…However, clinical trial outcomes clearly demonstrate considerable interindividual heterogeneity in the responsiveness of blood lipids to a wide spectrum of diet-based therapies [1].…”

Section: Introductionmentioning

confidence: 99%

Getting personal: considering variable interindividual responsiveness to dietary lipid-lowering therapies

Rideout¹

2011

Current Opinion in Lipidology

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“…Evolution has brought about minor changes of human genome but these are able to infl uence an individual′s metabolism and response to food (66).…”

Section: Nutrigenomics: Nutrient and Gene Interactionmentioning

confidence: 99%

Obesity: genome and environment interactions

Bašić

Butorac

Jurčević

et al. 2012

Archives of Industrial Hygiene and Toxicology

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Obesity has become one of the major threats for public health in industrialised world among adults, but also among adolescents and children. It is infl uenced by the interaction of genes, nutrition, environment, and lifestyle. Environmental and lifestyle risk factors include foetal and lifelong environment, nutrient quality, chemical and microbial exposure, and psychical stress, all of which are important contributing infl uences. Removing or limiting chemical and pharmaceutical obesogens from human environment could make a difference in the growing epidemic of obesity. Additionally, nutrigenomics describes how modifi cations in individual diets can improve health and prevent chronic diseases, as well as obesity, by understanding the effects of a genetic profi le in the interaction between food and increase in body weight. Furthermore, individual genetic variations in genome represent an individual′s predisposition for obesity. Therefore, the use of individual genetic information, avoiding obesogens, and a healthy lifestyle could help to improve the management of obesity and maintain a healthy weight.

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Nutrigenetics: links between genetic background and response to Mediterranean-type diets

Cited by 26 publications

References 20 publications

Genetic variation in lipid desaturases and its impact on the development of human disease

Genetic variation in lipid desaturases and its impact on the development of human disease

Getting personal: considering variable interindividual responsiveness to dietary lipid-lowering therapies

Obesity: genome and environment interactions

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