Nutrigenomic Functions of PPARs in Obesogenic Environments

Chung, Soonkyu; Kim, Young Jun; Yang, Soo Jin; Lee, Yunkyoung; Lee, Myoungsook

doi:10.1155/2016/4794576

Cited by 16 publications

(12 citation statements)

References 200 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unsaturated fatty acids are further ligands of the PPARs and activation of these nuclear receptors contributes to the metabolic and anti-inflammatory activities of these lipids [81]. RvE1 suppressed activation of NF-κB by a mechanism which partly depends on PPAR [82].…”

Section: Molecules Involved In Resolution Of Inflammationmentioning

confidence: 99%

Pro-Resolving Molecules—New Approaches to Treat Sepsis?

Buechler

Pohl

Aslanidis

2017

IJMS

View full text Add to dashboard Cite

Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches to down-modulate mediators relevant for the onset and duration of inflammation are successful in some chronic diseases, while all of them have failed in sepsis patients. Inflammation and immune suppression characterize sepsis, indicating that anti-inflammatory strategies alone are inappropriate for its therapy. Heme oxygenase 1 is a sensitive marker for oxidative stress and is upregulated in inflammation. Carbon monoxide, which is produced by this enzyme, initiates multiple anti-inflammatory and pro-resolving activities with higher production of omega-3 fatty acid-derived lipid metabolites being one of its protective actions. Pro-resolving lipids named maresins, resolvins and protectins originate from the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid while lipoxins are derived from arachidonic acid. These endogenously produced lipids do not simply limit inflammation but actively contribute to its resolution, and thus provide an opportunity to combat chronic inflammatory diseases and eventually sepsis.

show abstract

Section: Molecules Involved In Resolution Of Inflammationmentioning

confidence: 99%

Pro-Resolving Molecules—New Approaches to Treat Sepsis?

Buechler

Pohl

Aslanidis

2017

IJMS

View full text Add to dashboard Cite

show abstract

“…Previous studies have confirmed that peroxisome proliferator-activated receptors (PPARs) play a crucial role in regulating fatty acid oxidation and the upstream rate-limiting enzyme of fatty acid oxidation, carnitine palmitoyltransferase 1. 8 Despite similar structures, the three PPAR isotypes α, β, and γ vary greatly in their tissue distribution, pharmacology, type of endogenous ligand, and biological effects. Especially in the liver, PPARα acts as a master regulator of liver metabolism.…”

Section: Introductionmentioning

confidence: 99%

Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma

Xiao¹,

Cai²,

Liu³

et al. 2018

CMAR

View full text Add to dashboard Cite

IntroductionHepatocellular carcinoma (HCC) has a close relationship with lipid metabolism. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear.MethodsA total of 804 HCC specimens were collected to construct a tissue microarray and for immunohistochemical analysis. The relationship between PPARα expression and clinical features of HCC patients was analyzed. Kaplan–Meier analysis was conducted to assess the prognostic value of PPARα expression levels.ResultsThe expression of PPARα in HCC was noticeably decreased in HCC tissues. HCC patients with high levels of PPARα expression in cytoplasm had smaller tumors (P=0.027), less vascular invasion (P=0.049), and a higher proportion of complete involucrum (P=0.038). Kaplan–Meier analysis showed that HCC patients with low PPARα expression in the cytoplasm had significantly worse outcomes in terms of overall survival (P<0.001), disease-free survival (P=0.024), and the probability of recurrence (P=0.037). Similarly, overall survival was significantly shorter in HCC patients with negative PPARα expression in the nucleus (P=0.034). Multivariate Cox analyses indicated that tumor size (P=0.001), TNM stage (P<0.001), vascular invasion (P<0.001), and PPARα expression in the cytoplasm (P<0.001) were found to be independent prognostic variables for overall survival.ConclusionOur data revealed that PPARα expression was decreased in HCC samples. High PPARα expression was correlated with longer survival times in HCC patients, and served as an independent factor for better outcomes. Our study therefore provides a promising biomarker for prognostic prediction and a potential therapeutic target for HCC.

show abstract

“…The activation of PPARγ is either ligand-dependent due to the conformational change of the LBD or ligand-independent due to the kinase-mediated phosphorylation of the A/B domain [10]. Primed PPARγ can regulate target gene expression both positively and negatively by binding to specific PPREs in the regulatory sites of these genes [29]. The large Y-shaped ligand binding domain allows PPARγ to recognize many different ligands and to flexibly interact with ligands, which makes it possible for PPARγ to respond to various environmental stimuli and to modulate the expression of target genes [30].…”

Section: Structure Ligands and Signaling Pathways Of Pparγmentioning

confidence: 99%

The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review

Liu

Wang

Luo

et al. 2020

Journal of Autoimmunity

View full text Add to dashboard Cite

Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

show abstract

Nutrigenomic Functions of PPARs in Obesogenic Environments

Cited by 16 publications

References 200 publications

Pro-Resolving Molecules—New Approaches to Treat Sepsis?

Pro-Resolving Molecules—New Approaches to Treat Sepsis?

Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma

The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review

Contact Info

Product

Resources

About