Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review

Nasir, Ayesha; Bullo, Mir Muhammad Hassan; Ahmed, Zaheer; Imtiaz, Aysha; Yaqoob, Eesha; Jadoon, Mahpara; Ahmed, Hajra; Afreen, Asma; Yaqoob, Sanabil

doi:10.1080/10408398.2019.1571480

Cited by 114 publications

(80 citation statements)

References 61 publications

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“…Previous studies on breast cancer have been focusing on genetic and environmental factors [24]. In recent years, more evidence has revealed that social-psychological factors play a critical role in carcinogenesis progression [25].…”

Section: Discussionmentioning

confidence: 99%

Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

et al. 2020

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PurposeChronic stress and related hormones are key in cancer progression. Peroxisome proliferator-activated receptor γ (PPARγ) and its agonists was reported that inducing anti-tumor effect. However, the function of PPARγ in pro-tumorigenic effects induced by chronic stress in breast cancer remains unknown. Herein, we have characterized a novel role of PPARγ and vascular endothelial growth factor (VEGF)/fibroblast growth factor 2 (FGF2) signals in breast cancer promoted by chronic stress.Materials and MethodsWe performed experiments in vivo and in vitro and used bioinformatics data to evaluate the therapeutic potential of PPARγ in breast cancer promoted by stress.ResultsChronic stress significantly inhibited the PPARγ expression and promoted breast cancer in vivo. VEGF/FGF2-mediated angiogenesis increased in the chronic stress group compared to the control group. PPARγ agonist pioglitazone (PioG) injection offset the pro-tumorigenic effect of chronic stress. Moreover, specific β2-adrenergic receptor (β2R) antagonist ICI11-8551 inhibited the effect of chronic stress. In vitro, norepinephrine (NE) treatment had a similar tendency to chronic stress. The effect of NE was mediated by the β2R/adenylate cyclase signaling pathway and suppressed by PioG. PPARγ suppressed VEGF/FGF2 through reactive oxygen species inhibition. Bioinformatics data confirmed that therewas a lowPPARγ expression in breast invasive carcinoma. Lower PPARγ was associated with a significantly worse survival.Conclusion β2R activation induced by chronic stress and related hormones promotes growth and VEGF/FGF2-mediated angiogenesis of breast cancer by down-regulating PPARγ. Our findings hint that β receptor and PPARγ as two target molecules and the novel role for their agonists or antagonists as clinical medicine in breast cancer therapy

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Section: Discussionmentioning

confidence: 99%

Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

et al. 2020

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“…Phenolic compounds act on carcinogenesis throughout the induction of cell defense systems, including detoxifying and antioxidant enzyme systems, as well as the inhibition of the anti-inflammatory and anti-cellular growth signaling pathways that culminate in cell cycle arrest and/or cellular death. These contributions strongly suggest the anticancer effects of polyphenols, due to their ability to alter the epigenome of cancer cells (2,(9)(10)(11)(12)(13)(14). Specifically, natural polyphenolic compounds present in the diet can exert their anticancer effects through a variety of mechanisms, including the modulation of cell cycle signaling, the removal of anticancer agents, the activity of antioxidant enzymes, apoptosis and arrest of the cell cycle.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols in cancer prevention: New insights (Review)

et al. 2020

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A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific cancers. Resveratrol, epigallocatechin gallate and curcumin are among the most extensively studied polyphenols: The majority of the effects attributed to these compounds are linked to their antioxidant and anti-inflammatory properties. The multiple mechanisms involved include the modulation of molecular events and signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, hormonal activities, detoxification enzymes and immune responses. Notwithstanding their promising role in cancer prevention and treatment, polyphenols often have a poor bioavailability when administered as pure active principles, representing an important limit to their use. However, the bioavailability and thus the efficacy of these compounds can be improved by their administration in combination with other phytochemicals, with anticancer drugs or in polyphenol-loaded nanotechnology-based delivery systems. The possibility of combining conventional drugs with polyphenols offers very valuable advantages, such as the building of more efficient anticancer therapies with less side-effects on the health of patients. The present review focuses on current knowledge regarding the interactions between natural polyphenols and cancer development in order to gain a clearer comprehension of the potential mechanisms through which individual foods and food components may be exploited to reduce cancer risk. Contents 1. Introduction 2. Literature search 3. Classification of polyphenols 4. Prostate cancer 5. Colon cancer 6. Breast cancer 7. Lung cancer 8. Bladder cancer 9. Skin cancer 10. Pancreatic cancer 11. Leukemia 12. Conclusion

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“…In addition to standard cancer chemotherapy, an essential and new approach is the use of nutrigenomics, which possesses an enormous potential that can apply for the prevention and management of certain carcinomas and diseases. There is some evidence that dietary polyphenols substantially take part in the prevention of, among others, breast, skin, colorectal, prostate, pancreatic and lung cancers [26,27]. This evidence was the reason for investigating the effect of morin hydrate on ovarian cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Morin exerts anti-metastatic, anti-proliferative and anti-adhesive effect in ovarian cancer cells: an in vitro studies

2020

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The influence of morin hydrate on changes of proliferative, metastatic, and adhesive potential of human ovarian cancer cells concerning the influence of decitabine, and decitabine with trichostatin A, and in comparison to untreated cells, were analyzed. The effect of morin hydrate, decitabine, and trichostatin A were examined in A2780 and SKOV-3 ovarian cancer cell lines using MTS assay, clonogenic assay, adhesion to endothelial HMEC-1 cells, transwell migration assay and cell cycle analysis. The expression level of epithelial to mesenchymal transition (EMT) markers was quantified using PCR Array in relation to the level of global methylation determined with Methylated DNA Quantification Kit. We observed statistically significant inhibition of adhesive and migratory potential of both cell lines and the accumulation of G0/G1 phase A2780 cells after treatment with morin hydrate. Our studies confirmed the influence of morin hydrate on down-regulation of genes considered as up-regulated during EMT, and up-regulation of some genes considered as down-regulated during EMT in A2780 and SKOV-3 cells. Phenotypic changes were associated with molecular changes in cells, eg. decrease of the expression level of genes associated with adhesion, and an increase of genes down-regulated during EMT, after morin hydrate treatment in comparison to untreated control cells in both cell lines, were observed. Keywords Adhesion • Epithelial to mesenchymal transition • Metastasis • Morin hydrate • Ovarian cancer cells Abbreviations ATCC American type culture collection DNMT DNA methyltransferase ECACC European collection of authenticated cell cultures ECM Extracellular matrix EMT Epithelial to mesenchymal transition EOC Epithelial ovarian cancer HAT Histone acetyltransferase HDAC Histone deacetylase MET Mesenchymal to epithelial transition SAM S-sdenosyl-l-methionine TSA Trichostatin A

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Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review

Cited by 114 publications

References 61 publications

Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

Polyphenols in cancer prevention: New insights (Review)

Morin exerts anti-metastatic, anti-proliferative and anti-adhesive effect in ovarian cancer cells: an in vitro studies

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