Nutrigenomics of hepatic steatosis in a feline model: effect of monosodium glutamate, fructose, and Trans-fat feeding

Abstract

Nonalcoholic fatty liver disease begins with a relatively benign hepatic steatosis, often associated with increased adiposity, but may progress to a more severe nonalcoholic steatohepatitis with inflammation.

A Review of the Alleged Health Hazards of Monosodium Glutamate

“…MSG administration was associated with biochemical and morphological alterations of the heart tissue, as well as changes in cardiac rhythm (Kumar & Bhandari, ; Liu et al., ; Baky, Mohamed, & Faddah, ), and hepatotoxic effects, with fibrosis and neoplastic changes (Collison et al., ; Eweka, Igbigbi, & Ucheya, ), metabolic alterations and obesity (Diniz et al., , Hirata, Andrade, Vaskevicius, & Dolnikoff, ), neurotoxicity (Izumi et al., ; Rivera‐Cervantes et al., ; Swamy et al., ; Weil, Norman, DeVries, & Nelson, ), modified behavioral and physiological alterations, such as increased aggressivity, decreased locomotor activity, and loss of muscle strength (Campos‐Sepulveda et al., ). Significant changes in the neuronal redox homeostasis (increased levels of lipid peroxidation, nitrite concentration, decreased levels of antioxidants), and in the neuronal histology of the hippocampus, along with an increase of brain and serum cholinesterase (ChE) levels, were also reported (Onaolapo, Onaolapo, Akanmu, & Gbola, ; Sadek, Abouzed, & Nasr, ).…”

“…MSG seemed to interfere with hepatic gene expression. In a feline model (MSG diet: 30% protein and 1,125% MSG, with an average MSG intake of 201.4 ± 18.65 mg/kg), MSG exposure in utero in the first months of life led to obesity, steatosis, insulin secretion impairment, and alterations in the expression of genes involved in lipid metabolism (Collison et al., ; Tomankova et al., ).…”

Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

“…The most common form of liver disease in cats is hepatic lipidosis, for which obese animals are at higher risk [42] and which resembles human NAFLD. Because cats are considered an excellent model for the study of metabolic diseases in humans [43], feline liver organoids enable us to better understand individual differences in susceptibility and to identify cellular and molecular mechanisms of feline and human hepatic lipid‐storage diseases. Another common liver disease in cats is lymphocytic cholangitis, a classification of hepatobiliary disease [44].…”

Expression profiling feline peripheral blood monocytes identifies a transcriptional signature associated with type two diabetes mellitus

“…Total RNA was hybridised to the Affymetrix Feline GeneChip 1.0 ST Array microarray. Feline mRNA expression has previously been analysed by cross-hybridisation to human microarrays, as feline genes have generally >85% similarity to their human counterparts (Collison et al, 2012;Dowling and Bienzle, 2005), and whole blood expression profiling has been performed using a custom cDNA array (Gao et al, 2013). To our knowledge, this is only the first report of feline monocyte transcriptional profiling, using a feline-specific microarray.…”