Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors

Rodríguez‐Cruz, Maricela; Serna, Donovan Solís

doi:10.1016/j.nut.2017.04.012

Cited by 59 publications

(48 citation statements)

References 68 publications

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“…Fish oils, which are rich in fatty acids, show evidence of potential health benefits [1]. Large amounts of polyunsaturated fatty acids (PUFAs) are found in the extracts of fish oils.…”

Section: Introductionmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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Fish oil has been broadly reported as a potential supplement to ameliorate the severity of some skin disorders such as photoaging, skin cancer, allergy, dermatitis, cutaneous wounds, and melanogenesis. There has been increasing interest in the relationship of fish oil with skin protection and homeostasis, especially with respect to the omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The other PUFAs, such as α-linolenic acid (ALA) and linoleic acid (LA), also show a beneficial effect on the skin. The major mechanisms of PUFAs for attenuating cutaneous inflammation are the competition with the inflammatory arachidonic acid and the inhibition of proinflammatory eicosanoid production. On the other hand, PUFAs in fish oil can be the regulators that affect the synthesis and activity of cytokines for promoting wound healing. A systemic review was conducted to demonstrate the association between fish oil supplementation and the benefits to the skin. The following describes the different cosmetic and therapeutic approaches using fatty acids derived from fish oil, especially ALA, LA, DHA, and EPA. This review summarizes the cutaneous application of fish oil and the related fatty acids in the cell-based, animal-based, and clinical models. The research data relating to fish oil treatment of skin disorders suggest a way forward for generating advances in cosmetic and dermatological uses.

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“…Fish oils, which are rich in fatty acids, show evidence of potential health benefits [1]. Large amounts of polyunsaturated fatty acids (PUFAs) are found in the extracts of fish oils.…”

Section: Introductionmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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“…Die Expression zahlreicher lipogener Enzyme wie Acetyl-CoA-Carboxylase, Malatenzym und ATP-Zitratlyase wird vermindert, insbesondere durch DHA. Dies ist mit einer herabgesetzten Lipogenese verbunden [2].…”

Section: Stoffwechsel Von Mehrfach Ungesättigten Fettsäurenunclassified

“…Grundlegende Zusammenhänge sind bereits seit längerem bekannt, doch wurden viele Details der molekularen Wirkmechanismen von Omega-3-Fettsäuren erst kürzlich erkannt. Ihre Bedeutung unter verschiedenen physiologischen und pathologischen Bedingungen steht im Fokus zahlreicher aktueller Untersuchungen [1][2][3][4].…”

Section: Introductionunclassified

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Multiple Effekte von Omega-3-Fettsäuren im Fettgewebe

Richter

Blüher

Thiery

et al. 2020

Adipositas - Ursachen, Folgeerkrankungen, Therapie

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ZusammenfassungIm Fettgewebe üben Omega-3-Fettsäuren multiple Effekte aus, verbunden mit systemischen Wirkungen. Veränderungen der Fettsäure-Zusammensetzung zellulärer Membranen, die sich funktionell auswirken, Interaktionen mit Membran- und intrazellulären Rezeptoren und die Synthese einer Vielzahl bioaktiver Metabolite sind eingeschlossen. Besonders bedeutsam sind die anti-inflammatorischen und entzündungsauflösenden Wirkungen von Omega-3-Fettsäuren. Die Effekte langkettiger Omega-3-Fettsäuren wie Eicosapentaensäure (EPA) und Docosahexaensäure (DHA) sowohl auf metabolische als auch auf Immunzellen des Fettgewebes modulieren inflammatorische Prozesse und wirken Fettgewebe-Dysfunktionen bei Adipositas entgegen. Weil eine chronisch-subklinische Entzündung und Dysfunktionen im Fettgewebe Risikofaktoren für Adipositas-Folgeerkrankungen darstellen, ist eine ausgewogene Ernährung einschließlich optimaler Aufnahme von Omega-3-Fettsäuren mit gesundheitsfördernden Wirkungen unter den Bedingungen der Adipositas verbunden.

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“…It is considered a survival factor [11], it is involved in many physiological functions and in the pathogenesis of several diseases [12][13][14], particularly those related to cancer [12,[15][16][17]. LPA exerts its actions through the activation of a family of 6 GPCRs, called LPA [1][2][3][4][5][6] . [17].…”

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confidence: 99%

Free fatty acid receptor 4 agonists induce lysophosphatidic acid receptor 1 (LPA₁) desensitization independent of LPA₁ internalization and heterodimerization

et al. 2018

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The crosstalk between the free fatty acid receptor FFA4 and the lysophosphatidic acid receptor LPA seems to be of pathophysiological importance. We explored this crosstalk employing co-expression of fluorescent protein-tagged receptors. FFA4 activation induces functional desensitization of LPA receptors and phosphorylation of both receptors. LPA activation induces phosphorylation of LPA , but not of FFA4, and induces internalization of both receptors into heterogeneous types of vesicles. Docosahexaenoic acid (DHA) induces internalization of FFA4 but not of LPA . Fatty acid-induced FFA4-LPA interaction was observed using Förster resonance energy transfer and co-immunoprecipitation. Such interaction took place after desensitization was already established. Data indicate that FFA4 activation induces LPA desensitization in an internalization-independent process and that complex cellular processes participate in the crosstalk of these receptors.

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Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors

Cited by 59 publications

References 68 publications

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Multiple Effekte von Omega-3-Fettsäuren im Fettgewebe

Free fatty acid receptor 4 agonists induce lysophosphatidic acid receptor 1 (LPA₁) desensitization independent of LPA₁ internalization and heterodimerization

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Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors

Cited by 59 publications

References 68 publications

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Multiple Effekte von Omega-3-Fettsäuren im Fettgewebe

Free fatty acid receptor 4 agonists induce lysophosphatidic acid receptor 1 (LPA1) desensitization independent of LPA1 internalization and heterodimerization

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Product

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About

Free fatty acid receptor 4 agonists induce lysophosphatidic acid receptor 1 (LPA₁) desensitization independent of LPA₁ internalization and heterodimerization