Nutrigenomics, Vitamin D and Cancer Prevention

Davis, Cindy D.; Milner, John A.

doi:10.1159/000324175

Cited by 43 publications

(22 citation statements)

References 147 publications

(101 reference statements)

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“…In humans, vitamin D is obtained mainly through synthesis in skin by exposure to sunlight and, to a lesser extent, by directly ingestion in certain foods or supplements. Unfortified foods that contain vitamin D naturally are limited mainly to oily fish, liver, and egg yolks (23). Even with optimal nutrition, however, up to 90% of our daily vitamin D requirement is met through cutaneous production driven by exposure to sunlight (24).…”

Section: Vitamin Dmentioning

confidence: 99%

Cancer in North Cyprus: 1. Current Status, An Overview

et al. 2017

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This is the first of a two-part review dealing with cancer issues in North Cyprus (NC). Here we give an account of what is known about the cancer status of the island, which has been debated quite intensely over the years. From several independent reports, it is concluded that the epidemiology of cancer in NC has been steady around 200-230 per 100,000 for more than 20 years. This level is in line with the rest of Europe. Nevertheless, there are some potentially worrying signs. First, the "age-standardized rate" of some cancers (lung, skin, and liver) appears higher. Second, the "average age of incidence" is lower for breast and skin cancer in NC than in the rest of Europe. Relevant environmental factors of current interest that could contribute to these issues include the environmental levels of potentially carcinogenic heavy metals (e.g., arsenic, cadmium and lead) and the levels of vitamin D in the population. The particular case of the copper mines in the Lefke region is also covered. We conclude that (i) the overall cancer status of NC is broadly comparable to the rest of Europe, (ii) continuous monitoring of epidemiology is necessary, and (iii) research is needed into the possible cause(s) of cancer, especially environmental factors.

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Section: Vitamin Dmentioning

confidence: 99%

Cancer in North Cyprus: 1. Current Status, An Overview

et al. 2017

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“…Numerous studies have suggested that lower vitamin D level is a risk factor for human cancers, and vitamin D deficiency linked with the incidence and mortality of many types of cancers, including breast, colon, and prostate cancers [43,44].…”

Section: Vitamin D and Cancermentioning

confidence: 99%

“…VDR also played important role in anticancer effect. Some preliminary data suggested that VDR polymorphisms were more frequently associated with tumor genes which are Fok1, Bsm1, Taq1, Apa1, EcoRV, and Cdx2 [43][44][45].…”

Section: Vitamin D and Cancermentioning

confidence: 99%

“…There are many more reports and studies about vitamin D and its receptor which were found to play crucial role in many fields, such as vitamin D and obstructive sleep apnea in polycystic ovary syndrome (PCOS) patients [44], serum 25-hydroxy vitamin D levels in middle-aged women in relationship to adiposity and height trajectories [48], and vitamin D deficiency impairs skeletal muscle function in a smoking mouse model [49]. In engender, vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men [50].…”

Section: Other Diseasesmentioning

confidence: 99%

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The Multiple Roles of Vitamin D Besides Calcium-Phosphorus Metabolism

Guo¹,

Liu²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D is a kind of steroid hormone and is well known for its important role in regulating the levels of calcium (Ca) and phosphorus (P) as well as in mineralization of bone in body. But the vitamin D signaling also exhibits multiple effects, such as anti-inflammation effects, anticancer effect, and cardiovascular-and kidney-protective effects. From a practical point of view, vitamin D deficiency participates in many pathological progressions and diseases. In some diseases, the administration of vitamin D or vitamin D receptor agonist (VDRA) could rescue the clinical symptoms and improve outcomes. In this review, we briefly deal with these topics, limiting ourselves to comment on some novelty studies about vitamin D signaling, which might help us to understand the multiple effects of vitamin D in some pathological progresses and diseases, which are all worth to be studied further.

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“…Upon ligand binding, VDR heterodimerize with RXR or RAR, and regulate the transcription of more than a hundred genes, involved not only in calcium and phosphate homeostasis but also in cell proliferation, differentiation, and apoptosis (Chung et al 2009). Accumulating results revealed the association between vitamin D deficiency and vitamin D-related genes with different cancer types, including breast, prostate, colorectal, oral, lung cancer, melanoma and acute myeloid leukemia (Feldman et al 2014;Davis and Milner 2011;Zeljic et al 2012, Puccetti et al 2002. In addition, the gene expression of VDR and CYP24A1 gene, coding for 24-hydroxylase, enzyme involved in the vitamin D catabolism, and CYP27B1, coding for 1α-hydroxylase, involved in anabolism, is mediated by epigenetic modifications (Hobaus et al 2013;Fetahu et al 2014).…”

Section: Essential Micronutrientsmentioning

confidence: 99%

Epigenetic Impact of Bioactive Dietary Compounds in Cancer Chemoprevention

Šupić

Wagner

Magić

2016

Critical Dietary Factors in Cancer Chemoprevention

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Epigenetic changes refer to modifications caused by heritable but potentially reversible changes in gene expression not coded in the DNA sequence. Evidence has been provided that various environmental factors and dietary bioactive compounds contribute to cancer development through epigenetic mechanisms. The main mechanisms of epigenetic control in mammals are DNA methylation, histone modifications, and RNA silencing through noncoding RNAs. The inhibition of DNA methyltransferases (DNMTs) involved in DNA methylation of CpG-rich regions of gene promoters and various enzymes involved in the chromatin condensation such as histone deacetylases (HDACs) have been recognized as potent strategies for cancer therapy and chemoprevention. Treatments using natural compounds such as green tea polyphenols, soy isoflavones, curcumin, resveratrol, isothiocyanates, and butyrate (an intestinal product from dietary fiber) modulate DNMT or HDAC gene expression and/or protein levels and activities, indicating that natural compounds could have strong potential to reverse epigenetic changes, without the adverse toxic effects associated with synthetic epigenetic inhibitors used in chemotherapy. Further characterization of the chemopreventive properties of various dietary bioactive compounds is warranted to potentially establish the clinical utility of dietary factors as anticancer compounds either alone or in combination with other dietary factors or clinically relevant therapeutics. Moreover, these characterizations are useful for personalized dietary recommendations and chemopreventive strategies for reducing cancer incidence.

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Nutrigenomics, Vitamin D and Cancer Prevention

Cited by 43 publications

References 147 publications

Cancer in North Cyprus: 1. Current Status, An Overview

Cancer in North Cyprus: 1. Current Status, An Overview

The Multiple Roles of Vitamin D Besides Calcium-Phosphorus Metabolism

Epigenetic Impact of Bioactive Dietary Compounds in Cancer Chemoprevention

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