Nutriomics

Thangadurai, Devarajan; Islam, Saher; Nollet, Leo M.L.; Adetunji, Juliana Bunmi

doi:10.1201/9781003142195

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, conventional or modern medications are well recognized as more efficacious in reversing the diseased condition to the predisease stage by the administration of various therapeutic approaches, but certainly not to the normal health state [65]. Generally, conventional medications are inapplicable for prevention.…”

Section: Mechanisms Associating the Consumption Of Plant-based Compou...mentioning

confidence: 99%

Examination of Primary and Secondary Metabolites Associated with a Plant-Based Diet and Their Impact on Human Health

Simsek,

Whitney

2024

Foods

View full text Add to dashboard Cite

The consumption of plant-based diets has become a burgeoning trend, and they are increasingly consumed globally owing to their substantial energy intensity and dietetic advantages. Plants possess numerous bioactive components that have been recognized to exhibit manifold health-promoting assets. Comprehension of the synthesis of these primary and secondary metabolites by plants and their method of action against several chronic illnesses is a significant requirement for understanding their benefits to human health and disease prevention. Furthermore, the association of biologically active complexes with plants, humans, disease, medicine, and the underlying mechanisms is unexplored. Therefore, this review portrays various bioactive components derived from plant sources associated with health-promoting traits and their action mechanisms. This review paper predominantly assembles proposed plant-derived bioactive compounds, postulating valuable evidence aimed at perceiving forthcoming approaches, including the selection of potent bioactive components for formulating functional diets that are effective against several human disorders. This meticulous evidence could perhaps provide the basis for the advanced preemptive and therapeutic potential promoting human health. Hence, delivery opens possibilities for purchasers to approach the lucrative practice of plants as a remedy, produce novel products, and access new marketplaces.

show abstract

Section: Mechanisms Associating the Consumption Of Plant-based Compou...mentioning

confidence: 99%

Examination of Primary and Secondary Metabolites Associated with a Plant-Based Diet and Their Impact on Human Health

Simsek,

Whitney

2024

Foods

View full text Add to dashboard Cite

show abstract

“…These outcomes generate insights into how experimental factors interact to determine health. The challenge now is how best to analyze the datasets produced from these multi-factorial experiments, where the number of omics features tends to be much larger than the sample size (Floyd et al, 2022;Thangadurai et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

eNODAL: an experimentally guided nutriomics data clustering method to unravel complex drug-diet interactions

Xu,

Senior,

Le Couteur

et al. 2023

Preprint

View full text Add to dashboard Cite

Unraveling the complex interplay between nutrients and drugs via their effects on ‘omics’ features could revolutionize our fundamental understanding of nutritional physiology, personalized nutrition and ultimately human health-span. Experimental studies in nutrition are starting to use large-scale ‘omics’ experiments to pick apart the effects of such interacting factors. However, the high dimensionality of the omics features, coupled with complex fully-factorial experimental designs together pose a challenge to the analysis. Current strategies for analyzing such types of data are based on between-feature correlations. However, these techniques risk overlooking important signals that arise from the experimental design and produce clusters that are hard to interpret. We present a novel approach for analyzing high-dimensional outcomes in nutriomics experiments, termedexperiment-guidedNutriOmicsDatAcLustering (eNODAL). This three-step hybrid framework takes advantage of both ANOVA-type analyses and unsupervised learning methods to extract maximum information from experimental nutriomics studies. First, eNODAL categorizes the omics features into interpretable groups based on the significance of response to the different experimental variables using an ANOVA-like test. Such groups may include the main effects of a nutritional intervention, and drug exposure, or their interaction. Second, consensus clustering is performed within each interpretable group to further identify subclusters of features with similar response profiles to these experimental factors. Third, eNODAL annotates these subclusters based on their experimental responses and biological pathways enriched within the subcluster. We validate eNODAL using data from a mouse experiment to test for the interaction effects of macronutrient intake and drugs that target aging mechanisms in mice.

show abstract

Edible oil-producing plants in the Sinja Valley, Jumla, Nepal

Khadka,

Paudel,

Luo

et al. 2023

Front. Sustain. Food Syst.

View full text Add to dashboard Cite

The indigenous people of Nepal have accumulated knowledge of plants and their uses spanning millennia of oral history, but the current sociodemographic trend threatens the transition of this knowledge. Recording the uses and knowledge of these plants is therefore imperative for revitalizing the traditions and culture and the sustainable use and availability of plant species. We interviewed a total of 80 Sinja Valley residents. We calculated the relative frequency of citations (RFC) of recorded edible oil plants. Using the Kruskal-Wallis test and the Wilcoxon test for gender, the difference in the use of edible oil plants mentioned by age group, education level, and occupation of the respondents was determined. These interviews yielded knowledge on 13 different edible oil-producing plant species (EOPPs) including nine indigenous species and six collected from the wild. EOPPs helped effectively treat 19 disorders with Prunus mira being considered a very good treatment for gastritis. Prinsepia utilis was the most common and frequently used (RFC = 0.99) edible oil-producing plant. Most respondents reported that oil-producing and oil-consuming cultures vary and are decreasing among Sinja Valley residents. The locals were subsistence farmers, and the edible oils for their household purposes were prepared using traditional knowledge. However, the tradition is scourged by commercially-available tawdry oil. In rural areas, the knowledge of edible oil-producing plants has been decimated due to outmigration and sociocultural transformation. Edible oil production from indigenous plants should continue for the culture and conservation of rural livelihood.

show abstract

Nutriomics

Cited by 3 publications

References 0 publications

Examination of Primary and Secondary Metabolites Associated with a Plant-Based Diet and Their Impact on Human Health

Examination of Primary and Secondary Metabolites Associated with a Plant-Based Diet and Their Impact on Human Health

eNODAL: an experimentally guided nutriomics data clustering method to unravel complex drug-diet interactions

Edible oil-producing plants in the Sinja Valley, Jumla, Nepal

Contact Info

Product

Resources

About