Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19

Yu, Boxuan; Yu, Ligen; Klionsky, Daniel J.

doi:10.1016/j.mehy.2021.110668

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…These aspects should be taken into great account when approaching COVID-19 patients and their nutritional status and risk of rapid malnutrition development. Moreover, high-protein formulas and protein derivatives can have direct anti-viral and anti-inflammatory effects in COVID-19 [35]. The vast majority of the patients in this study population were able to reach a normal threshold for serum pre-albumin levels.…”

Section: Discussionmentioning

confidence: 79%

Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients

et al. 2022

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The novel SARS-CoV-2 virus has led to a severe pandemic, starting from early 2020. Intensive care (ICU) management of the COVID-19 disease is difficult with high morbidity and mortality. Early nutritional support, especially with whey protein, seems to be crucial in this medical case. Thus, we aimed to assess the effects of an adequate nutritional protocol rich in whey protein on nutritional and inflammatory status, extubating time, and mortality of critically ill COVID-19 patients (CICP). Methods: A prospective single-center exploratory observational study was undertaken on 32 consecutive CICP admitted to the ICU of Santa Maria Hospital, Terni, Italy, and treated with whey protein-enriched formula. Patients’ demographics, nutritional status, indexes of inflammation, daily pre-albumin serum levels, duration of mechanical ventilation, and mortality were recorded. Results: Thirty-two patients were enrolled. Ninety-five percent of them showed a gradual reduction in C-reactive protein (CRP) values and increase in pre-albumin levels after the whey protein-enriched formula. Prealbumin levels were not correlated with a better nutritional status but with a shorter extubating time and better survival. Conclusions: An adequate administration of whey protein during COVID-19 patients’ ICU stays can provide fast achievement of protein targets, reducing the duration of mechanical ventilation, and improving inflammatory status and ICU survival. Further prospective and large-scale, controlled studies are needed to confirm these results.

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Section: Discussionmentioning

confidence: 79%

Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients

et al. 2022

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“…This debris can also be turned into lipid intermediates, and induce lipotoxicity. The human immune system also has a pivotal role in nutrition acquisition from the pathogen or the commensal microbiota like bacteria and the damaged tissues [ 77 ], and uses them for tissue regeneration if these nutrients just meet the need of tissue regeneration without surplus.…”

Section: Discussionmentioning

confidence: 99%

Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review

Maitre

Mahalli

Micheneau

et al. 2021

IJERPH

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This review aims to clarify the nature of the link between Alzheimer’s disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. We performed a systematic review, following the Preferred Reporting Items for Systematic Reviews checklist, from January 2000 to July 2021. The terms “plaque,” “saliva,” and “mouth” were associated with the search term “oral diseases” and used in combination with the Boolean operator “AND”/”OR”. We included experimental or clinical studies and excluded conferences, abstracts, reviews, and editorials. A total of 27 articles were selected. Evidence for the impact of the oral microbiome on the pathophysiological and immunoinflammatory mechanisms of Alzheimer’s disease is accumulating. The impact of the oral microbiome on the development of AD opens the door to complementary therapies such as phototherapy and/or the use of prebiotic compounds and probiotic strains for global or targeted modulation of the oral microbiome in order to have a favourable influence on the evolution of this pathology in the future.

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“…At this time, nutrient metabolism and immunity are interrelated and integrated and play essential roles in disease prevention and immunonutrition acquisition [14]. In the event of microbial/viral infections, the nutritional flux produced by infected host cell self-destruction (inflammation) together with those produced by daily homeostatic apoptosis [15] may create transient overnutrition [16]. Such transient overnutrition can be dissipated through cell or tissue regeneration.…”

mentioning

confidence: 99%

“…It is well documented that excessive serum amino acids from high protein feeding results in increased hepatic de novo lipogenesis [17,18]. As cell self-destruction and cell debris degradation can also generate amino acids that circulate throughout the circulatory system, when the nutrition generated by the degradation of infection-damaged cells exceeds the nutritional requirements for tissue regeneration, most of the excess nutrients will be converted into lipid intermediates [16]. Lipid intermediates will invade healthy non-adipose tissue, leading to lipotoxicity [8,9] and further tissue damage.…”

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confidence: 99%

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Cell Self-Destruction (Programmed Cell Death), Immunonutrition and Metabolism

2023

Biology

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Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19

Cited by 10 publications

References 11 publications

Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients

Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients

Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review

Cell Self-Destruction (Programmed Cell Death), Immunonutrition and Metabolism

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