Nutrition and age-related eye diseases: The Alienor (Antioxydants, lipides essentiels, nutrition et maladies oculaires) study

Delcourt, Cécile; Korobelnik, J.-F.; Barberger‐Gateau, Pascale; Delyfer, M.-N.; Rougier, M.–B.; Goff, Mélanie Le; Malet, Florence; Colin, Joseph; Dartigues, Jean François

doi:10.1007/s12603-010-0131-9

Cited by 86 publications

(140 citation statements)

References 50 publications

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“…43 Participants were recruited from an on-going population-based study analyzing risk factors for dementia, the Three-City (3C) Study. 44 In 1999 to 2001, the 3C study randomly recruited participants aged 65 years or older on electoral rolls from three French cities (Bordeaux, Dijon, and Montpellier).…”

Section: Study Populationmentioning

confidence: 99%

“…Among the 1450 participants enrolled at this follow-up, 963 (66.4%) accepted the ALIENOR study's baseline eye examination. Delcourt et al 43 published demographic characteristics of participants included at baseline, and their comparison with nonparticipants.…”

Section: Study Populationmentioning

confidence: 99%

“…The methods chosen to diagnose glaucoma in the ALIENOR study were published in details and used the classification provided by Foster et al 43,45,48 Briefly, the vertical cup:disc ratio (VCDR) and the minimal rim:disc ratio were estimated from optic disc photographs. Participants were classified as suspects for glaucoma when, in at least one eye, VCDR was greater than or equal to 0.65 and/or minimal rim:disc ratio less than or equal to 0.1 or when an asymmetry of VCDR between eyes greater than or equal to 0.2 was observed.…”

Section: Glaucoma Diagnosismentioning

confidence: 99%

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Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study

Schweitzer

Cougnard‐Grégoire

Rigalleau

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Glaucoma Diagnosismentioning

confidence: 99%

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Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study

Schweitzer

Cougnard‐Grégoire

Rigalleau

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…34 It also takes into account other major determinants of eye disease, including gene polymorphisms, lifestyle, and vascular factors.…”

Section: Study Purposementioning

confidence: 99%

“…Detailed characteristics of participants and nonparticipants have been published elsewhere. 34 This research followed the tenets of the Declaration of Helsinki. Participants gave written consent for participation in the study.…”

Section: Study Samplementioning

confidence: 99%

Long-Term Blood Pressure and Age-Related Macular Degeneration: The ALIENOR Study

Cougnard‐Grégoire

Delyfer

Korobelnik

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To explore the association of AMD with long-term average blood pressure (BP) parameters, including pulse pressure (PP). METHODS.The ALIENOR study is a population-based study on age-related eye diseases in 963 residents of Bordeaux, France, aged 73 years or older. AMD was graded from nonmydriatic color retinal photographs, in three exclusive stages: no AMD (1015 eyes), large soft distinct drusen and/or large soft indistinct drusen and/or reticular drusen and/or pigmentary abnormalities (early AMD, 276 eyes), and late AMD (66 eyes). BP parameters were measured at four occasions over a 7-year period. PP was defined as systolic BP minus diastolic BP. Associations of AMD with BP parameters were estimated using generalized estimating equation logistic regressions. Statistical analyses included 702 subjects (1357 eyes) with complete data. RESULTS.After adjustment for age, sex, educational level, smoking, body mass index, plasma HDL and LDL cholesterol, CFH Y402H, ApoE2, ApoE4, and ARMS2 A69S polymorphisms, elevated PP was significantly associated with an increased risk of late AMD (odds ratio [OR] ¼ 1.37 for a 10-mm Hg increase, 95% confidence interval [CI]: 1.03-1.82). Associations were similar for late atrophic and late neovascular AMD (OR ¼ 1.39, 95% CI: 1.01-1.92, P ¼ 0.04, and OR ¼ 1.43, 95% CI: 0.90-2.23, P ¼ 0.13, respectively). Association with early AMD was in the same direction but did not reach statistical significance (OR ¼ 1.12, 95% CI: 0.98-1.28). Early and late AMD were not significantly associated with systolic or diastolic BP, hypertension, or use of antihypertensive medications.CONCLUSIONS. This study suggests that high PP may be associated with increased risk for AMD. (Invest Ophthalmol Vis Sci. 2013;54:1905-1912) DOI:10.1167/iovs.12-10192 A ge-related macular degeneration (AMD) is the leading cause of visual impairment and blindness in the elderly in North America and other Western countries. 1 The resulting loss of vision is associated with significant limitations in activities of daily living, while life expectancy is still increasing. AMD is a multifactorial disease, resulting from both nonmodifiable factors (age, sex, genetic susceptibility) and modifiable factors (smoking, nutrition). The control of these modifiable factors may represent a preventive means to reduce its incidence. Among these factors, cardiovascular risk factors, including smoking, 3-9 abdominal obesity, 4,7,10,11 and blood pressure (BP), 12-18 have received much attention for their potential role in the development and progression of AMD. However, except for smoking, epidemiological studies have reported conflicting results, particularly for BP, as some studies [13][14][15][16][17][18] found associations between higher risk of AMD and elevated blood pressure, while others did not. 7,8,10,[19][20][21][22][23] Studies that explored the impact of BP on cardiovascular diseases have demonstrated that long-term average BP is a better determinant of risk for cardiovascular disease events, 24,25 as the effect of high BP seems...

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ARMS2 A69S Polymorphism and the Risk for Age-Related Maculopathy: The ALIENOR Study

Delcourt¹,

Delyfer²,

Rougier³

et al. 2012

Arch Ophthalmol

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Nutrition and age-related eye diseases: The Alienor (Antioxydants, lipides essentiels, nutrition et maladies oculaires) study

Cited by 86 publications

References 50 publications

Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study

Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study

Long-Term Blood Pressure and Age-Related Macular Degeneration: The ALIENOR Study

ARMS2 A69S Polymorphism and the Risk for Age-Related Maculopathy: The ALIENOR Study

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