Nutrition and Asthma

Monteleone, Catherine

doi:10.1001/archinte.1997.00440220027005

Cited by 52 publications

(21 citation statements)

References 41 publications

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“…In literature, a drop in breathing frequency below 70% of the normal breathing frequency is considered an indication of severe respiratory effects (Botham et al 1989). Although we observed severe respiratory effects in only a few animals (~10-15% of the animals), this low incidence agrees with observations from food allergic patients, of whom only about 10% react with respiratory problems (Monteleone and Sherman 1997). In several animals (~40% of the animals), a decrease in systolic blood pressure was observed, but no dramatic drop in blood pressure, resulting in circulatory collapse, was observed.…”

Section: Resultssupporting

confidence: 90%

Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model.

Knippels¹,

Penninks²

2003

Environ Health Perspect

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The need for widely accepted and validated animal models to test the potential allergenicity and potency of novel (biotechnology-derived) proteins has become an important issue for their safety evaluation. In this article, we summarize the results of the development of an oral sensitization protocol for food proteins in the rat. Young Brown Norway rats were exposed to either various purified allergenic proteins (e.g., ovalbumin, partly purified), a whole food (cow's milk), or total protein extracts (hen's egg white, peanut) by daily gavage dosing during 42 days without the use of an adjuvant. The results showed that Brown Norway rats can be sensitized orally to the various allergenic food proteins tested, resulting in antigen-specific immunoglobulin (Ig) G and IgE responses, without the use of adjuvants. Animals orally exposed to cow's milk or total protein extracts of egg white also developed specific IgE and IgG antibodies that recognized the same proteins compared with antibodies from patients allergic to egg white or cow's milk. We also studied local and systemic immune-mediated effects. In ovalbumin-sensitized rats, some clinical symptoms of food allergy were studied upon an oral challenge with ovalbumin. The results demonstrated that gut permeability was increased and that in some animals breathing frequency and systolic blood pressure were temporarily decreased. The results obtained show that the Brown Norway rat provides a suitable animal model for food allergy research and for the study of relative allergenicity of existing and novel food proteins.

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Section: Resultssupporting

confidence: 90%

Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model.

Knippels¹,

Penninks²

2003

Environ Health Perspect

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“…Several studies have shown that intravenous Mg application could alleviate symptoms in acute and chronic asthma (Monteleone & Sherman, 1997). The therapeutic effect of Mg in asthma results from its involvement in modulating smooth muscle contractility (Rolla et al, 1987) and in promoting mediator release through its antagonism with calcium (Levine & Coburn, 1984).…”

Section: Asthmamentioning

confidence: 99%

Possible roles of magnesium on the immune system

et al. 2003

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During the last few years, magnesium (Mg) has been subject of research due to its functionality in the organism. It is one of the most important micronutrients, and therefore its role in biological systems has been extensively investigated. Particularly, Mg has a strong relation with the immune system, in both nonspecific and specific immune response, also known as innate and acquired immune response. The aim of this paper is to review the state of the art about the interactions between Mg and the immune system. We discuss the link between dietary Mg and inflammation, apoptosis and alterations in number and function of innate immune cell populations, described in animal models. Furthermore, the immune system can be compromised in human populations under certain circumstances, including athletes and elderly people. The importance of a balanced Mg homeostasis and its interaction with the immune system in these groups has also been reviewed. Although emerging data support the relevant role of Mg in the immune response, further research is needed; and special efforts should be made to establish the most adequate dose in nutritional supplements to reach beneficial effects on health.

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“…Mediators derived from EPA have diminished biological activity compared with the arachidonic acid-derived mediators. Several experimental studies, reviewed by Monteleone & Sherman (1997), have shown that supplementation of a Western diet (which is rich in n-6 fatty acids) with EPA and docosahexaenoic acid from fish led to increased docosahexaenoic acid and EPA content in cell membranes. However, often no improvement in the clinical manifestation of asthma was observed (Arm et al 1988;Kirsch et al 1988).…”

Section: Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Dietary influences on chronic obstructive lung disease and asthma: a review of the epidemiological evidence

1999

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The epidemiological evidence for a relationship between diet and indicators of asthma and chronic obstructive pulmonary disease (COPD) is evaluated. The review focuses on the intake of Na,n−3 fatty acids, and antioxidant vitamins as well as fruit and vegetables. Experimental studies suggest that a high-Na diet has a small adverse effect on airway reactivity in asthma patients. However, observational studies provide no clear evidence that high Na intake has adverse effects on airway reactivity or asthma symptoms in open populations.n−3 Polyunsaturated fatty acids, which are present in fish oils, are metabolized into less broncho-constricting and inflammatory mediators thann−6 polyunsaturated fatty acids. Studies in the general adult population suggest that a high fish intake has a beneficial effect on lung function, but the relationship with respiratory symptoms and clinically-manifest asthma or COPD is less evident. Also, experimental studies in asthma patients have not demonstrated an improvement in asthma severity after supplementation with fish oil. Several studies showed a beneficial association between fruit and vegetable intake and lung function, but the relationship with respiratory symptoms and the clinically-manifest disease was less convincing. A similar pattern was found for vitamin C in relation to indicators of asthma and COPD, but there are still conflicting results with respect to vitamin E and β-carotene. In conclusion, the epidemiological evidence for a beneficial effect on indicators of asthma and COPD of eating fish, fruit and vegetables is increasing. However, the effectiveness of dietary supplementation in open-population samples is often not demonstrated. Several unresolved questions are raised, which should be addressed in future studies on the relationship between diet and respiratory disease.

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Nutrition and Asthma

Cited by 52 publications

References 41 publications

Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model.

Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model.

Possible roles of magnesium on the immune system

Dietary influences on chronic obstructive lung disease and asthma: a review of the epidemiological evidence

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