Nutrition and bipolar disorder: a systematic review

Gabriel, Fernanda C.; Oliveira, Manoela Lima; Martella, Bruna De M.; Berk, Michael; Brietzke, Elisa; Jacka, Felice N.; Lafer, Beny

doi:10.1080/1028415x.2022.2077031

Cited by 24 publications

(15 citation statements)

References 123 publications

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“…Omega-3 fatty acids have been studied for their neuroprotective properties, namely α-linolenic, eicosapentaenoic, and docosahexaenoic acids. These acids have been found to improve bipolar symptoms (Gabriel et al 2022 ).…”

Section: Oxidative Stress Diseases Aging and Antioxidant Interventionsmentioning

confidence: 99%

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Jomova,

Raptova,

Alomar

et al. 2023

Arch Toxicol

520

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A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2–related factor 2 (Nrf2) and other processes. Increased levels of ROS/RNS, generated from both endogenous (mitochondria, NADPH oxidases) and/or exogenous sources (radiation, certain drugs, foods, cigarette smoking, pollution) result in a harmful condition termed oxidative stress (“bad stress”). Although it is widely accepted, that many chronic diseases are multifactorial in origin, they share oxidative stress as a common denominator. Here we review the importance of oxidative stress and the mechanisms through which oxidative stress contributes to the pathological states of an organism. Attention is focused on the chemistry of ROS and RNS (e.g. superoxide radical, hydrogen peroxide, hydroxyl radicals, peroxyl radicals, nitric oxide, peroxynitrite), and their role in oxidative damage of DNA, proteins, and membrane lipids. Quantitative and qualitative assessment of oxidative stress biomarkers is also discussed. Oxidative stress contributes to the pathology of cancer, cardiovascular diseases, diabetes, neurological disorders (Alzheimer’s and Parkinson’s diseases, Down syndrome), psychiatric diseases (depression, schizophrenia, bipolar disorder), renal disease, lung disease (chronic pulmonary obstruction, lung cancer), and aging. The concerted action of antioxidants to ameliorate the harmful effect of oxidative stress is achieved by antioxidant enzymes (Superoxide dismutases-SODs, catalase, glutathione peroxidase-GPx), and small molecular weight antioxidants (vitamins C and E, flavonoids, carotenoids, melatonin, ergothioneine, and others). Perhaps one of the most effective low molecular weight antioxidants is vitamin E, the first line of defense against the peroxidation of lipids. A promising approach appears to be the use of certain antioxidants (e.g. flavonoids), showing weak prooxidant properties that may boost cellular antioxidant systems and thus act as preventive anticancer agents. Redox metal-based enzyme mimetic compounds as potential pharmaceutical interventions and sirtuins as promising therapeutic targets for age-related diseases and anti-aging strategies are discussed.

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Section: Oxidative Stress Diseases Aging and Antioxidant Interventionsmentioning

confidence: 99%

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Jomova,

Raptova,

Alomar

et al. 2023

Arch Toxicol

520

View full text Add to dashboard Cite

show abstract

“…Given this and the extent to which suicide is a public health concern, it is surprising that so few studies have systematically examined lithium's effects on It is worth noting that the therapeutic potential of microdoses of lithium have been considered for indications beyond neuropsychiatric health, ranging from antiviral interventions (Rybakowski, 2022) to proposals that it should be considered as an essential micronutrient facilitating the functions of vitamins and folates (Schrauzer, 2002). Of interest here are the intricate links between several factors associated with affective disorders (for whom lithium is the primary mood stabiliser) and the other phenomena for which lithium has been demonstrated as beneficialnutrition, (Gabriel et al, 2022) suicidality, (Baldessarini and Tondo, 2003) substance use (Strakowski and DelBello, 2000) and cognitive impairment (Tsapekos et al, 2021). As such, even in affective disorder patients for whom standard-doses of lithium are not suitable, a low dose may ultimately be more effective than no dose.…”

Section: Discussionmentioning

confidence: 99%

Identifying the neuropsychiatric health effects of low-dose lithium interventions: A systematic review

Strawbridge

Kerr-Gaffney

Bessa

et al. 2023

Neuroscience & Biobehavioral Reviews

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“…The study found that one-third of the participants, after 12 weeks of diet intervention, were in remission compared with 8% who were provided with social support only. Similarly, another recent study demonstrated a correlation between nutritional intake or supplementation of unsaturated fatty acids (omega-3), fish and zinc in improving mood disorder symptoms, particularly bipolar disorder [ 13 ]. Other studies have identified that supplementation or increased intake of omega-3, B vitamins, vitamin D, and other nutrients may provide neurochemical modulation which benefits the treatment and management of mood disorders [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Perceptions of Mental Health Professionals on Nutritional Psychiatry as an Adjunct Treatment in Mainstream Psychiatric Settings in New South Wales, Australia

Minhas,

Mcbride

2024

Cureus

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Background Nutritional psychiatry refers to the practice of using food, or nutrition, as alternative or complementary treatment for mental health disorders. It is a growing area of research that has shown links between the biological processes in the gut and how the food we consume can impact cognitive function, which then can impact our mood and behaviour. However, there is a lack of understanding on the knowledge and education of nutritional psychiatry in mental health clinicians, and further, how nutritional psychiatry, if at all, is practised in psychiatric clinical settings. Therefore, this study aims to investigate the perceptions, knowledge, and education of mental health professionals within the state of New South Wales, Australia regarding their clinical practice and knowledge of nutritional psychiatry. Methods In this cross-sectional study, a self-administered structured questionnaire created by the authors was successfully completed by 40 mental health professionals (mental health nurses, occupational therapists, psychologists, medical officers, and other allied health workers) who were working in New South Wales, Australia. 49 questionnaires were attempted with nine excluded due to these being predominantly incomplete, including demographic data only or empty, ensuring integrity of the remaining data and analysis. The questionnaire aimed to uncover their perceptions, knowledge, and education in nutritional psychiatry and its role in mental health settings. The questionnaire included 16 questions that covered various themes such as the frequency and importance of discussing nutrition with patients, nutrition referrals for issues regarding nutrition, the value of including nutritional psychiatry in their clinical practice, and clinician training and willingness to train or gain further education in nutritional psychiatry. Data was analysed through a series of frequency tables to categorise patterns and identify patterns through the use of descriptive statistics in our analysis of the distribution of attitudes and practices among mental health professionals regarding nutritional psychiatry. Results A total of 40 mental health clinicians successfully completed the survey and their results were analysed. The results suggest that most clinicians (85% to 93%) recognised the importance of nutrition in mental health, however, revealed various barriers which hindered their clinical practice such as a lack of time, knowledge, and access to nutritional services. Further, 54% of clinicians rated their knowledge of nutritional psychiatry as low, however, 92% revealed that they would attend nutritional psychiatry training if given the opportunity. Additionally, the clinicians reported varied levels of education in nutrition, with 43% reporting no education at all on nutrition in their preclinical studies. Conclusions Clinicians recognise the importance of nutrition in mental health settings, but revealed lack of time, knowledge, and n...

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Nutrition and bipolar disorder: a systematic review

Cited by 24 publications

References 123 publications

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Identifying the neuropsychiatric health effects of low-dose lithium interventions: A systematic review

Perceptions of Mental Health Professionals on Nutritional Psychiatry as an Adjunct Treatment in Mainstream Psychiatric Settings in New South Wales, Australia

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