Nutrition and Brain Functions in Health and Disease

Mansour, Heba M.

doi:10.1007/978-981-19-5021-6_1

Cited by 3 publications

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References 106 publications

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“…Antioxidant and anti-inflammatory actions, as well as hypothalamic-pituitary-adrenal (HPA) axis modulation, neurotransmitter production, and neurotrophic actions, are regulated. The highlighted relationships of dietary nutrients on brain functions in health and psychiatric diseases have revealed some of the critical mechanisms underpinning a diet's effect on brain health, which will aid in controlling how best to use dietary nutrients to boost neuronal resistance to injuries and promote mental health [3] .…”

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confidence: 99%

Biochemical role of experimentally induced malnutrition on depressed brain and moderate mood with blood picture in chicken

Mohammed,

Desouky,

Mohammed

et al. 2023

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Background: Nutritional deficiency and malnutrition induce cyclothymia, depressed mood, and anemia. Therefore, in the present study, we experimentally induced malnutrition in chickens to follow up on brain functions and anemia profiles (blood indices) in chickens. Material and methods: The study was conducted on two groups of 60 one-day-old chicks that were fed a commercial starter diet for 10 days and were equally divided into two groups for 6 weeks. The first control group was fed a commercial grower and finisher ration during the growing and finishing periods, while the second test group, which was deficient, was fed yellow corn constantly during the growing and finishing periods. All chicks were weighed weekly for six weeks to record weight differences. Whole Blood samples and brain homogenates were collected from ten chicks in each group every two weeks to evaluate brain tissue homogenate parameters, differential leukocyte count, CBC, and blood indices. Results: In the food deficiency group, acetylcholine esterase (ACHE) and total antioxidant capacity (TAC) consistently increased throughout the study period. Tumor necrosis factor-alpha (TNF-α) increased after the second and fourth weeks but showed no significant difference after the sixth week. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) increased significantly in the control group during the entire experiment. In terms of blood counts, white blood cells (WBCs) were consistently higher in the food deficiency group. Eosinophils were significantly elevated after two and four weeks but not after six weeks. Lymphocytes were elevated in the control group after the second week and in the food deficiency group after six weeks. Staff neutrophils increased significantly in the food deficiency group after six weeks, while monocytes increased after two weeks in the food deficiency group and after six weeks in the control group. Basophils and segmented neutrophils increased after two weeks in the food deficiency group but showed no significant differences after four and six weeks in either group. Furthermore, hemoglobin (Hb), red blood cells (RBCs), packed cell volume (PCV), mean corpuscular volume (MCV), and platelet count increased significantly in the control group throughout the study. Mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) increased significantly after four and six weeks in the control group. Conclusion: malnutrition can have a high effect on brain function and blood parameters.

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Section: Introductionmentioning

confidence: 99%

Biochemical role of experimentally induced malnutrition on depressed brain and moderate mood with blood picture in chicken

Mohammed,

Desouky,

Mohammed

et al. 2023

FNC

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“…统，导致各种血细胞生成减少。营养不良并伴有贫血等血液学异常的人死亡风险会增加 [1] 。白细胞减少症和白细胞增多症是由 PEM(蛋白质-能量营养不良)感染引起的，形成营养不良与感染之间的联系，营养状况不足会影响白细胞生成 [2] 。摄入充足的膳食营养对大脑的正常功能至关重要。大量证据表明，膳食营养有助于治疗和预防许多精神和神经疾病。脂肪酸和氨基酸等宏量营养素以及维生素和矿物质等微量营养素对神经元功能、突触可塑性、记忆、神经炎症和神经元信号网络等各种大脑功能都有影响。研究膳食营养素的潜在神经保护机制非常重要。抗氧化和抗炎作用以及下丘脑-垂体-肾上腺(HPA)轴调节、神经递质产生和神经营养作用都受到调控。膳食营养素对健康和精神疾病中大脑功能的重要关系揭示了膳食影响大脑健康的一些关键机制，这将有助于控制如何最好地利用膳食营养素来增强神经元对损伤的抵抗力和促进精神健康 [3]…”

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实验性诱导营养不良对鸡脑部抑郁和情绪中等以及血液影响的生物化学作用

Mohammed,

Desouky,

Mohammed

et al. 2023

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背景：营养缺乏和营养不良会引起周期性嗜睡、情绪低落和贫血。因此，在本研究中，我们通过实验诱导鸡营养不良，以跟踪鸡的脑功能和贫血状况（血液指数）。材料和方法：本研究以两组60只一天龄的雏鸡为研究对象，这些雏鸡喂食商品开食料10天，然后平均分成两组，饲养6周。第一对照组在生长期和育成期饲喂商品生长料和育成料，而第二试验组在生长期和育成期持续饲喂黄玉米。所有雏鸡在六周内每周称重一次，以记录体重差异。每两周从每组的10只雏鸡中采集全血样和脑匀浆，以评估脑组织匀浆参数、白细胞计数差异、全血细胞计数和血液指数。结果：比较两组雏鸡的脑组织匀浆发现，缺食组的乙酰胆碱酯酶（AChE）和总抗氧化能力（TAC）在整个饲养过程中显著增加，而肿瘤坏死因子-α（TNF-α）在缺食组第二周和第四周后增加，第六周后两组无显著差异。对照组的谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）在整个实验期间都明显增加，而全血细胞计数（CBC）和细胞差异计数显示，食物缺乏组的白细胞（WBCs）在整个实验期间都明显增加、嗜酸性粒细胞浓度在缺食组两周和四周后明显升高，六周后两组差异不明显；淋巴细胞在对照组第二周后明显升高，四周后差异不明显，六周后缺食组则明显升高。缺食组的中性粒细胞计数在第六周后明显偏高，单核细胞浓度在缺食组中两周后明显升高，四周后无明显差异，在对照组中六周后明显升高。嗜碱性粒细胞和分段中性粒细胞在食物缺乏组两周后明显增加，两组在四周和六周后差异不明显。此外，对照组的血红蛋白（Hb）、红细胞（RBCs）、包装细胞容积（PCV）、平均体细胞容积（MCV）和血小板计数在整个持续时间内均显著增加，对照组的平均体细胞血红蛋白（MCH）和平均体细胞血红蛋白浓度（MCHC）在四周和六周后显著增加。结论：营养不良会对大脑功能和血液参数产生很大影响。

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Therapeutic Strategies for Combating Reactive Oxygen Species in Cardiovascular Diseases

Mansour

2024

Oxidative Stress in Applied Basic Research and Clinical Practice

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Nutrition and Brain Functions in Health and Disease

Cited by 3 publications

References 106 publications

Biochemical role of experimentally induced malnutrition on depressed brain and moderate mood with blood picture in chicken

Biochemical role of experimentally induced malnutrition on depressed brain and moderate mood with blood picture in chicken

实验性诱导营养不良对鸡脑部抑郁和情绪中等以及血液影响的生物化学作用

Therapeutic Strategies for Combating Reactive Oxygen Species in Cardiovascular Diseases

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