Nutrition and bullous skin diseases

Fedeles, Flavia; Murphy, Michael J.; Rothe, Marti Jill; Grant‐Kels, Jane M.

doi:10.1016/j.clindermatol.2010.03.036

Cited by 37 publications

(29 citation statements)

References 156 publications

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“…In the literature, in one dyshidrosiform pemphigoid patient who described nutritional factors as the triggering factor, the lesions completely cleared with a nickel-poor diet. It was also mentioned that there was no response with gluten-free diets in BP patients in whom antigliadin antibodies were present in the peripheral blood (9,11). In our study, tomato was found to be associated with itching (maybe due to the rich histamine content) in all of the pemphigoid patients, and garlic was found to possibly be associated in one of the patients.…”

Section: Discussionmentioning

confidence: 58%

“…Although comorbid inflammatory and infectious conditions, malignancies, and endocrinological disorders have been mentioned in some patients in the literature, exogenous triggering factors may also play a role in the etiology of ABDs by regulating the immune response or by changing the antigenic properties of the epidermal basal membrane. Determining and removing these factors may aid in the prevention of exacerbations of the disease (8)(9)(10)(11)15). In this study, it was aimed to determine the triggering factors and comorbidities in newly diagnosed ABD patients in order to control the disease in a rapid way and to decrease morbidities.…”

Section: Discussionmentioning

confidence: 99%

“…These substances may either be incorporated into keratinocytes or may release sequestered desmoglein antigens from immunologically privileged sites, and may also interfere with immune balance. It has been suggested that vegetables in the genus Allium that are rich in thiol (like onion, garlic, leek, and chive) and foods in the tannin group that are rich in phenol (like black pepper, red pepper, sweet cherry, raspberry, cranberry, blackberry, mango, avocado, peach, cashew nuts, ginger, ginseng, red wine, tea, vanillin, cacao), isothiocyanate (like mustard, radish, cauliflower, broccoli, turnip, cabbage, kale), phycocyanins (blue-green algae such as Spirulina platensis), and cinnamic acid (like tomato, grape, orange) may trigger pemphigus (8,11). Tsankov et al found an association between disease activity and triggering factors in 42% of their pemphigus patients, and they reported stress as the most frequent triggering factor (16).…”

Section: Discussionmentioning

confidence: 99%

“…Sex, age, age at onset of disease, the interval between the first complaint and the diagnosis, place of residence (rural or urban), family history, tobacco and alcohol habits (three groups: active smoker before the disease onset, former smoker but nonactive in the last 6 months, nonsmoker), triggering factors described by patients, and specific triggering factors of ABDs (e.g., medication, ultraviolet exposure, nutritional factors, chemical agent exposure, topical applications, infections, vaccination, emotional stress, trauma, malignancy, and/or radiotherapy history) were examined with a standardized questionnaire form. It was determined whether the drugs that were still in use had triggering properties (8)(9)(10)(11). Autoimmune Bullous Skin Disorder Intensity Scores (ABSISs) with localization and distribution of lesions were recorded following dermatological examinations (12).…”

Section: Methodsmentioning

confidence: 99%

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Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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IntroductionAutoimmune bullous diseases (ABDs) are a group of rarely seen organ-specific diseases caused by pathogenic autoantibodies against target antigens that function in the intercellular or the mesenchymal/dermal junction of the epidermis. Clinically, ABDs display quite a wide spectrum of vesicle or bulla formations on the skin and/or the mucous membranes. ABDs are classified mainly as intraepidermal bullous disease (pemphigus) and subepidermal bullous diseases (pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa), according to the depth of blister formation on the skin and types of autoantibodies against structural proteins (1). Generally, pemphigus vulgaris (PV) and bullous pemphigoid (BP) form the greater portion of ABDs, and therefore they are the most frequently known ABDs (1,2).The demographic, clinical, and etiological characteristics of ABDs and the incidence of subgroups vary according to geographic regions (1,2). In Turkey, despite the absence of national data, the first annual incidence estimations in the Mediterranean and Aegean regions of the country were reported as 2.4 and 1.8 per million by Uzun et al. and Bozdag and Bilgin, respectively (3,4). However, it was observed that these limited numbers of published data were of retrospective nature and focused on pemphigus only (3-5). Nevertheless, one of the two recently published retrospective studies from Turkey covered pemphigus with other ABDs, and the other included patients with hereditary bullous diseases and other ABDs (6,7). In this study we aimed to evaluate demographic data, clinical characteristics, related triggering factors, and comorbidities of newly diagnosed patients with ABDs at our clinic.Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Materials and methods:In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined. Furthermore, the distribution of lesions and autoimmune bullous skin disorder intensity scores were recorded.Results: Of the total 59 ABD patients, 26 (44.1%) were diagnosed with pemphigus, 25 (42.4%) were diagnosed with pemphigoid, and 8 (13.5%) were diagnosed with dermatitis herpetiformis. Although there were some differences between the subgroups of ABDs, the onset of the disease was associated with a triggering factor (stress, foods, physical trauma, chemical agents, ultraviolet rays, medications, infections, malignancies, and pregnancy, in a decreasing frequency) in 96.6% of the patients. Autoimmune diseases, ...

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…B. Zöliakie) oder Vitaminmangelkrankheiten (z. B. Pellagra) [34][35][36][37] oder Beriberi [38][39][40][41] sowie Infektionen (z. B. HIV, Diphtherie, Lepra [42,43]) eine Neuropathie.…”

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Diabetische Retinopathie und diabetisches Fußsyndrom bei Diabetikern in Kinshasa (Demokratische Republik Kongo)

Knappe

Stoll

et al. 2012

Klin Monatsbl Augenheilkd

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It was evident that there is a considerable discrepancy between partly extensive foot ulcerations and only mild to moderate diabetic retinopathy in most of the patients. This indicates that neuropathy-induced foot problems and microangiopathy-induced diabetic retinopathy are diabetic complications whose formal pathogenesis is only loosely correlated. Additional risk factors in local African conditions compared to Europe may play a major role in this discrepancy.

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Porphyria cutanea tarda

1970

Archives of Dermatology

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Nutrition and bullous skin diseases

Cited by 37 publications

References 156 publications

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Diabetische Retinopathie und diabetisches Fußsyndrom bei Diabetikern in Kinshasa (Demokratische Republik Kongo)

Porphyria cutanea tarda

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