Nutrition and Dry Eye

Aragona, Pasquale; Rania, Laura; Micali, Antonio; Puzzolo, Domenico

doi:10.1007/s40135-013-0011-7

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…Decreased pyridoxal 5'-phosphate plasma level decreased B6 vitamin synthesis due to pyridoxal synthesis (Girard, Matte, 1999). It has been reported that vitamin B6 deficiency affects the ocular surface and causes dry eyes (Aragona et al, 2013). Our study has shown that dry eye and visual blurring side effects occur with alteration of thiamine metabolism.…”

Section: Discussionsupporting

confidence: 61%

Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment

Akman

Kadıoğlu

Şenol

et al. 2022

Braz. J. Pharm. Sci.

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Changes in metabolite levels of patients using the long-term drug can be comprehensively demonstrated by pharmacometabolomic studies. In this study, biological alterations induced by the administration of solifenacin succinate were investigated with a pharmacometabolomics approach on rat metabolism. Plasma samples obtained from rats were analyzed by LC-Q-TOF/MS/MS. METLIN and HMDB databases were used to identify metabolites. Data were processed and classified with MATLAB 2017b. 53 m/z values were found to be significantly different between the drug and control groups (p ≤ 0.01 and fold analysis > 1.5) and identified by comparing METLIN and HMDB databases. According to multivariate data analysis, changes in arachidonic acid, thromboxane A2, palmitic acid, choline, calcitriol, histamine phosphate, retinyl ester, l-cysteine, l-leucine, beta-alanine, l-histidine levels were found to be statistically significant compare to the control group. Differences in the biosynthesis of phenylalanine, aminoacyl-tRNA, tyrosine, tryptophan, metabolism of glycerophospholipid, cysteine, methionine, histidine, arachidonic metabolism have been successfully demonstrated by the metabolomics approach. Our study provides important information to explain the efficacy and toxicity of chronic administration of solifenacin succinate.

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Section: Discussionsupporting

confidence: 61%

Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment

Akman

Kadıoğlu

Şenol

et al. 2022

Braz. J. Pharm. Sci.

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“…The inter-individual variability in each group, however, was high, with coefficients of variation exceeding 30%. This was not entirely surprising as there are genetic and environmental factors that can individually affect tear production and composition, such as hormonal and nutritional stimuli [ 15 , 16 ]. In these experiments, the saline wash group contained little or no protein, indicating that collection by microcapillary tube efficiently removes the protein content from the tear film.…”

Section: Resultsmentioning

confidence: 99%

Short-Term Reproducibility of MUC5AC Measurement in Human Tear Fluid

2021

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The assessment of tear fluid components is a common and valuable approach to understanding ocular surface disease and testing the efficacy of novel therapeutic strategies. However, the interpretation and utility of the findings can be limited by changes in the composition of the tear film, particularly in studies requiring repetitive patient sampling. Here, tear samples were collected twice within a one-hour interval to evaluate the short-term reproducibility of an immunoassay aimed to measure the amount of MUC5AC mucin. We found no statistical difference in total protein or MUC5AC content between the two consecutive collections of tear fluid, although the inter-individual variability in each group was high, with coefficients of variation exceeding 30% and 50%, respectively. Scatterplots showed a significant correlation in both protein and MUC5AC following collection within a one-hour interval. These data indicate that, regardless of the high inter-individual variability, repeated collection of tear fluid within an hour interval produces reproducible intra-individual data in terms of MUC5AC mucin content, and suggest that the normal mucin composition of the tear fluid can be re-established within an hour of the initial collection.

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“…Therefore, a differential diagnosis should include CF in cases of corneal disorders in children without prior CF NBS. Nonsevere corneal abnormalities, such as keratinization, can be reversible after supplementation, especially with vitamin A and nutritional compensation [ 97 ]. Corneal ulcers require the implementation of intensive topical treatment with fluoroquinolones and often systemic empiric antibiotic therapy, while, after revealing the pathogenic factor in culture, targeted antibiotic therapy should be implemented; however, in severe cases—not amenable to pharmacological treatment—corneal keratoplasty is necessary [ 98 ].…”

Section: Management Of Cf-related Ocular Complicationsmentioning

confidence: 99%

Ocular Changes in Cystic Fibrosis: A Review

Liberski,

Confalonieri,

Cofta

et al. 2024

IJMS

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Cystic fibrosis (CF), also known as mucoviscidosis, is the most common autosomal recessive genetic disease in the Caucasian population, with an estimated frequency of 1:2000–3000 live births. CF results from the mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene localized in the long arm of chromosome 7. The product of CFTR gene expression is CFTR protein, an adenosine triphosphate (ATP)-binding cassette (ABC) transporter that regulates the transport of chloride ions (Cl−) across the apical cell membrane. Primary manifestations of CF include chronic lung and pancreas function impairment secondary to the production of thick, sticky mucus resulting from dehydrated secretions. It is well known that CF can cause both anterior and posterior ocular abnormalities. Conjunctival and corneal xerosis and dry eye disease symptoms are the most characteristic manifestations in the anterior segment. In contrast, the most typical anatomical and functional changes relating to the posterior segment of the eye include defects in the retinal nerve fiber layer (RNFL), vascular abnormalities, and visual disturbances, such as reduced contrast sensitivity and abnormal dark adaptation. However, the complete background of ophthalmic manifestations in the course of CF has yet to be discovered. This review summarizes the current knowledge regarding ocular changes in cystic fibrosis.

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Nutrition and Dry Eye

Cited by 5 publications

References 49 publications

Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment

Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment

Short-Term Reproducibility of MUC5AC Measurement in Human Tear Fluid

Ocular Changes in Cystic Fibrosis: A Review

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