Nutrition and Immunity in Perinatal Hypoxic-Ischemic Injury

Gandecha, Hema; Kaur, Avineet; Sanghera, Ranveer; Preece, Joanna; Pillay, Thillagavathie

doi:10.3390/nu14132747

Cited by 2 publications

(3 citation statements)

References 113 publications

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“…Our study showed a specific increase in the risk of mortality due to respiratory diseases between the 50th and 150th days of life. This might have been possible due to a cumulative effect of critical negative factors during early infancy, for example, immunological immaturity and deteriorated response to infections, poor defense mechanisms, incomplete vaccination schedule, or transient iron deficiency [40][41][42][43]. There is also a possibility that some additive physiological or pathogenic mechanisms are involved in exacerbating the health issues, including an increased risk of morbidity and mortality between the second and the fourth month of age.…”

Section: Discussionmentioning

confidence: 99%

Emission of Industrial Air Pollution and Mortality Due to Respiratory Diseases: A Birth Cohort Study in Poland

Genowska

Strukčinskienė

Jamiołkowski

et al. 2023

IJERPH

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Background: Air pollution is a major risk factor for public health worldwide, but evidence linking this environmental problem with the mortality of children in Central Europe is limited. Objective: To investigate the relationship between air pollution due to the emission of industry-related particulate matter and mortality due to respiratory diseases under one year of age. Methods: A retrospective birth cohort analysis of the dataset including 2,277,585 children from all Polish counties was conducted, and the dataset was matched with 248 deaths from respiratory diseases under one year of age. Time to death during the first 365 days of life was used as a dependent variable. Harmful emission was described as total particle pollution (TPP) from industries. The survival analysis was performed using the Cox proportional hazards model for the emission of TPP at the place of residence of the mother and child, adjusted individual characteristics, demographic factors, and socioeconomic status related to the contextual level. Results: Infants born in areas with extremely high emission of TPP had a significantly higher risk of mortality due to respiratory diseases: hazard ratio (HR) = 1.781 [95% confidence interval (CI): 1.175, 2.697], p = 0.006, compared with those born in areas with the lowest emission levels. This effect was persistent when significant factors were adjusted at individual and contextual levels (HR = 1.959 [95% CI: 1.058, 3.628], p = 0.032). The increased risk of mortality was marked between the 50th and 150th days of life, coinciding with the highest exposure to TPP. Conclusions: The emission of TPP from industries is associated with mortality due to respiratory diseases under one year of age. A considerable proportion of children’s deaths could be prevented in Poland, especially in urban areas, if air pollution due to the emission of particle pollution is reduced.

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Section: Discussionmentioning

confidence: 99%

Emission of Industrial Air Pollution and Mortality Due to Respiratory Diseases: A Birth Cohort Study in Poland

Genowska

Strukčinskienė

Jamiołkowski

et al. 2023

IJERPH

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“…The cellular‐molecular mechanisms of the role of metabolic diseases in the damage caused by HI in the newborn are not well understood. However, there is increasing evidence on the role of nutrition and metabolic diseases in the immune response and repair in neonatal HI (Gandecha et al, 2022; Maiuolo et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Evidence has shown that suffering from metabolic diseases increases the level of inflammation in the brain tissue (Gandecha et al, 2022; Maiuolo et al, 2021; Sadeghi et al, 2016). Also, the increase in inflammation following metabolic diseases leads to an increase in the expression of genes related to the apoptosis of nerve cells, such as Bcl‐2 and caspase‐3 (Gandecha et al, 2022; Maiuolo et al, 2021; Sadeghi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effect of type 1 diabetes during pregnancy and lactation on neonatal hypoxia‐ischemia injury and apoptotic gene expression

Azadbakht

Fanaei

Karajibani

et al. 2023

Intl J of Devlp Neuroscience

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Objective Hypoxia‐ischemia (HI) is one of the major disorders that causes a variety of abnormalities and infant mortality. Type 1 diabetes is one of the most common worldwide metabolic disorders, and its prevalence has become one of the public health concerns of the 21st century. This study aims to evaluate the effect of type 1 diabetes during pregnancy and lactation on vulnerability to neonatal HI in rats. Materials and methods Female Wistar rats (weighing 200 ± 220 g) were randomly assigned into two groups: Group 1 (rats that received 0.5 mL/day of normal saline solution) and Group 2 (type 1 diabetes was induced in rats on the second day of pregnancy with a single dose of intraperitoneal injection of alloxan monohydrate [150 mg/kg]). After delivery, offspring were divided into four groups: (a) Control (Co), (b) Diabetic (DI), (c) Hypoxia‐ischemia (HI), (d) HI + Diabetic (HI + DI). Seven days after HI induction, neurobehavioral tests were performed, and then cerebral edema, infarct volume, inflammatory factors, Bax‐Bcl2 expression, and oxidative stress were measured. Results The BAX level in the DI + HI (p = 0.0355) group was significantly higher than the HI group. The Bcl‐2 expression levels in the HI (p = 0.0027) and DI + HI (p < 0.0001) groups were significantly lower than the DI group. Total antioxidant capacity (TAC) levels in the DI + HI (p < 0.0001) group were significantly lower than HI and CO groups. TNF‐α, CRP, and total oxidant status (TOS) levels in the DI + HI (p < 0.0001) group were significantly higher than the HI group. Infarct volume and cerebral edema in the DI + HI (p < 0.0001) group were significantly higher than the HI group. Conclusion According to the results, type 1 diabetes during pregnancy and lactation increased the destructive effects of HI injury in pups. It also decreased the expression of the anti‐apoptotic Bcl‐2 and increased the expression BAX apoptosis factor gene in pups.

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Nutrition and Immunity in Perinatal Hypoxic-Ischemic Injury

Cited by 2 publications

References 113 publications

Emission of Industrial Air Pollution and Mortality Due to Respiratory Diseases: A Birth Cohort Study in Poland

Emission of Industrial Air Pollution and Mortality Due to Respiratory Diseases: A Birth Cohort Study in Poland

Effect of type 1 diabetes during pregnancy and lactation on neonatal hypoxia‐ischemia injury and apoptotic gene expression

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