Nutrition and motility disorders

Karamanolis, George; Tack, Jan

doi:10.1016/j.bpg.2006.01.005

Cited by 40 publications

(31 citation statements)

References 145 publications

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“…It is interesting to notice that many of these dietary items have been associated to the generation of gastrointestinal symptoms in previous studies assessing patients with FD, irritable bowel syndrome, or other motility disorders [5,7,8]. The mechanisms by which dietary factors induce dyspeptic symptoms still need clarification.…”

Section: Discussionmentioning

confidence: 98%

Food Intolerance, Diet Composition, and Eating Patterns in Functional Dyspepsia Patients

et al. 2009

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The aims of this study are to investigate dietary factors, food intolerance, and the body mass index data, as an indicator of nutritional status, in functional dyspepsia patients. Forty-one functional dyspepsia patients and 30 healthy volunteers answered a standardized questionnaire to identify eating habits and food intolerance, and then completed a 7-day alimentary diary. There was no significant difference in daily total caloric intake between patients and controls. Patients associated their symptoms with the ingestion of several foods, but in general maintained their regular intake, with the exception of a small reduction in the proportion of fat in comparison with controls (median 28 vs. 34%; P = 0.001). No patient was underweight. In conclusion, our results suggest that food intolerance has no remarkable influence on food pattern and nutritional status in most functional dyspepsia patients. Further studies are necessary to clarify the role of fat in the generation of dyspeptic symptoms.

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Section: Discussionmentioning

confidence: 98%

Food Intolerance, Diet Composition, and Eating Patterns in Functional Dyspepsia Patients

et al. 2009

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“…Comparative studies of patients with IBS and healthy controls have found no differences in results of skin prick tests and immuno-detection of serum-specific IgE antibodies to food antigens[30]. Studies to determine the role, if any, of IgG/IgG4-mediated hypersensitivity in IBS have also been inconclusive[26,31].…”

Section: Introductionmentioning

confidence: 99%

Possible therapeutic role of IgE blockade in irritable bowel syndrome

Magen

Chikovani

2016

WJG

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Omalizumab is a humanized monoclonal antibody that binds to the high-affinity type-I IgE Fc receptors on mast cells (MCs) and basophils, inhibiting the IgE immune pathway. Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, and dysregulation of the immune system likely contributes to its etiology and/or symptomatology. Colonic biopsies from patients with IBS demonstrate considerable increase in the number of degranulating MCs releasing histamine in proximity to nerves, and this event may underlie the common IBS symptom of abdominal pain. Pharmacologic control of MC activation and mediator release is a current area of active interest in the field of IBS research. Recently, we and Pearson et al described 2 cases of patients with IBS with diarrhea (IBS-D) showing positive clinical response to omalizumab. In both cases, the female patients had severe, long-lasting IBS-D and achieved an almost complete resolution of IBS symptoms. Both patients were also able to discontinue all IBS medications after commencing the anti-IgE therapy. For both patients, the omalizumab treatment showed a relatively rapid onset of action, resembling the efficacy observed in and previously reported for patients with chronic spontaneous urticaria. In this Editorial, we discuss the possible biological mechanisms that may underlie the clinical efficacy of omalizumab in IBS. We suggest that there is a need for a well-designed prospective study to investigate the therapeutic effects of anti-IgE in IBS.

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“…Different food items and beverages may modulate gastrointestinal (GI) motor and sensory functions, and provoke GI symptoms [14]. Two-third of IBS patients believes that their complaints are related to diet [15].…”

Section: Introductionmentioning

confidence: 99%

Sex differences in dietary coping with gastrointestinal symptoms

Faresjö¹,

Johansson

Faresjö³

et al. 2010

European Journal of Gastroenterology &Amp; Hepatology

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Aim Nutritional changes are often considered first line treatment in public health diseases which apply to many gastrointestinal disorders, since different food and beverages may modulate gastrointestinal (GI) motor and sensory functions, and provoke GI symptoms. The aim of this study was to examine dietary coping and possible changes of food and beverages intakes in relation to GI symptoms reported by identified IBS patients compared to healthy controls and if any gender differences were seen in these respects.Methods A population-based case-control design was used. Three primary health care centres in the city of Linköping in Sweden. The IBS cases were recruited from the studied primary health care centres based on diagnoses from computerized medical records. The controls were randomly selected from the general population in the same region. A questionnaire was used with specific questions about self-reported food and beverages increase or decrease of GI symptoms and self-reported changes in dietary habits.Results Female IBS-cases appear to be more willing to change dietary habits due to their GI-problems than males. Effects of these nutritional behaviour changes were reported for almost all participants that had made dietary adjustments. Fatty food, certain vegetables, dairy products and egg were significantly more reported to cause GI complaints among IBS-cases compared to their controls.Conclusions Female IBS-cases reported more changes in their dietary habits due to GI-problems than males with the disease. The majority of both females and males that changed their dietary habits due to GI problems experienced symptoms improvement.

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Nutrition and motility disorders

Cited by 40 publications

References 145 publications

Food Intolerance, Diet Composition, and Eating Patterns in Functional Dyspepsia Patients

Food Intolerance, Diet Composition, and Eating Patterns in Functional Dyspepsia Patients

Possible therapeutic role of IgE blockade in irritable bowel syndrome

Sex differences in dietary coping with gastrointestinal symptoms

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