Nutrition and nail disease

Muddasani, Suraj; Lin, Gloria H. Y.; Hooper, Jette; Sloan, Brett

doi:10.1016/j.clindermatol.2021.05.009

Cited by 10 publications

(11 citation statements)

References 49 publications

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“…The onychocorneal band is the first line of defense against materials penetrating under the nail plate. In general terms, the matrix of the nail is responsible for the nail plate creation, residing on the bed of the nail, and is framed and ensheathed by the nail folds and the hyponychium 4,21 .…”

Section: Onychodermal Bandmentioning

confidence: 99%

Understanding the drug delivery through nails: a comprehensive review

Bhattacharjee

Dey

Barman

et al. 2021

J. Drug Delivery Ther.

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The nail unit is the largest cutaneous musculo-skeletal appendage. The management of nail disorders is an onerous task owing to the disease manifestations and anatomical structure of the nail plate. The topical treatment of nail infections/disorders has been a centerpiece of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. However, transungual delivery had its challenges. This necessitated a lookout for novel approaches that enhanced treatment efficacy and reduced treatment time. Moreover, curing the nail condition using topical delivery has been challenging due to the lack of a validated animal model to determine the efficacy of the formulation and to establish a mathematical model that can help in predicting the desirable attributes of the formulation and permeation of various molecules through the nail plate. This review is based on publications retrieved by a selective search in PubMed. The purpose of this review is to provide an overview of nail anatomy and its disorders, factors affecting nail delivery, diagnostic procedures, current approaches, and promising approaches to treat nail infections/disorders including nail lacquers and the role of permeation enhancers, in-vitro models. This review also covers current available treatments and treatments under clinical trial. Keywords: Musculo-skeletal, Nail infection, Transungual, Mathematical model, In-vitro models.

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Section: Onychodermal Bandmentioning

confidence: 99%

Understanding the drug delivery through nails: a comprehensive review

Bhattacharjee

Dey

Barman

et al. 2021

J. Drug Delivery Ther.

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“…The anatomy and physiology of fingernails make them an excellent matrix for the retention of alcohol biomarkers specifically. The fingernail’s keratin composition allows for a variably strong yet porous surface that allows for the incorporation of drugs or chemicals . Fingernails and toenails’ chemical composition remain unaffected when drugs or chemicals are introduced into the nail as it continues to grow. , Thus, as alcohol consumption continues, the alcohol biomarkers will accumulate in the keratin fibers for months showing history of use …”

mentioning

confidence: 99%

“…The microscopic physical striations of fingernails have also been explored and compared as ridge patterns . A fingernail’s appearance and physical composition may provide insight into nail diseases, mineral or vitamin deficiencies, poor nutrition, and recent trauma . Exposure and contaminants such as poison, chlorine, and explosives have also been mentioned within the literature. ,,− Particularly, alcohol biomarkers found in the body after the consumption of alcohol may be present as aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), or carbohydrate deficient transferrin (CDT) biomarkers, to name a few.…”

mentioning

confidence: 99%

“…A fingernail’s appearance and physical composition may provide insight into nail diseases, mineral or vitamin deficiencies, poor nutrition, and recent trauma . Exposure and contaminants such as poison, chlorine, and explosives have also been mentioned within the literature. ,,− Particularly, alcohol biomarkers found in the body after the consumption of alcohol may be present as aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), or carbohydrate deficient transferrin (CDT) biomarkers, to name a few. However, the particular alcohol biomarker of interest in monitoring alcohol abuse is ethyl glucuronide (EtG), considering it is a resulting product only when ethanol is being metabolized in the liver. , …”

mentioning

confidence: 99%

“…Alcohol biomarkers are one of many drug markers which have been found in fingernail clippings, including parent drug and or metabolites of tobacco, marijuana, THC, opiates and opioids, nicotine, PCP, Zolpidem, Bromazepam, Benzodiazepines, Amphetamine and Methamphetamine, Cocaine, and Benzoylecgonine. ,,,− Research pertaining to understanding the incorporation of drugs or chemicals during nail formation have explored various methods of ingestion, including in utero drug exposure by analyzing infants’ fingernails. ,, …”

mentioning

confidence: 99%

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Attenuated Total Reflection Fourier Transform Infrared Spectroscopy for Forensic Screening of Long-Term Alcohol Consumption from Human Nails

et al. 2023

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Fourier transform infrared (FT-IR) spectroscopy is used throughout forensic laboratories for many applications. FT-IR spectroscopy can be useful with ATR accessories in forensic analysis for several reasons. It provides excellent data quality combined with high reproducibility, with minimal user-induced variations and no sample preparation. Spectra from heterogeneous biological systems, including the integumentary system, can be associated with hundreds or thousands of biomolecules. The nail matrix of keratin possesses a complicated structure with captured circulating metabolites whose presence may vary in space and time depending on context and history. We developed a new approach by using machine-learning (ML) tools to leverage the potential and enhance the selectivity of the instrument, create classification models, and provide invaluable information saved in human nails with statistical confidence. Here, we report chemometric analysis of ATR FT-IR spectra for the classification and prediction of long-term alcohol consumption from nail clippings in 63 donors. A partial least squares discriminant analysis (PLS-DA) was used to create a classification model that was validated against an independent data set which resulted in 91% correctly classified spectra. However, when considering the prediction results at the donor level, 100% accuracy was achieved, and all donors were correctly classified. To the best of our knowledge, this proof-of-concept study demonstrates for the first time the ability of ATR FT-IR spectroscopy to discriminate donors who do not drink alcohol from those who drink alcohol on a regular basis.

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The Hybrid Vision Transformer Approach for Hyperpigmentation Nail Disease Detection

Kumar

Nijhawan

et al. 2022

Lecture Notes in Networks and Systems

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Nutrition and nail disease

Cited by 10 publications

References 49 publications

Understanding the drug delivery through nails: a comprehensive review

Understanding the drug delivery through nails: a comprehensive review

Attenuated Total Reflection Fourier Transform Infrared Spectroscopy for Forensic Screening of Long-Term Alcohol Consumption from Human Nails

The Hybrid Vision Transformer Approach for Hyperpigmentation Nail Disease Detection

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