Background
Oral squamous cell carcinoma (OSCC) is the most common of head and neck malignancies in well-developed countries. In most cases, patients with OSCC experience a degree of nutritional status disturbances and decreased quality of life (QoL). This study aimed to compare nutritional status and QoL in 51 patients before and after surgery for OSCC.
Material/Methods
Fifty-one eligible patients with OSCC were followed during a 3-year period (2019–2022). For all patients, we determined body mass index (BMI), serum albumin (ALB), prognostic nutritional index, and nutritional risk index before and after treatment. Also, all patients completed a standardized QoL questionnaire before and after treatment. The obtained data were compared between the groups by using the
t
test and multivariate Cox regression.
Results
The values of BMI and NRI were statistically significantly different between the preoperative and postoperative measurements (24.1 kg/m
2
vs 21.1 kg/m
2
, and 103 vs 100.1, respectively,
P
=0.001), while values of ALB and prognostic nutritional index did not differ significantly (41.35 g/L vs 39.1 g/L, and 48.5 vs 46.2, respectively). Dysphagia (
P
=0.03) and chewing problems
(P
=0.04) were found to be the 2 most important factors decreasing the QoL of patients.
Conclusions
Based on our results, BMI and NRI were the most sensitive parameters of nutritional status. Dysphagia and chewing problems were the 2 most important factors affecting the QoL in patients with OSCC.