Nutrition and the ageing eye

Carneiro, Ângela

doi:10.1002/9781118823408.ch8

Cited by 3 publications

(14 citation statements)

References 107 publications

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“…The retina possesses an antioxidant system with several components, but vitamins C and E and the carotenoids lutein and zeaxanthin are the most important [28]. Both vitamins cooperate to decrease the retinal epoxide adducts and also participate in the protection from blue light-induced damage [29].…”

Section: The Human Eye and The Oxidative Stressmentioning

confidence: 99%

“…Zeaxanthin is, therefore, a more effective antioxidant in the area where the risk of oxidative damage is higher [30]. In addition, both carotenoids are found in the outer segments of rods and probably of cones, particularly rich in DHA and, therefore, potentially vulnerable to lipid oxidation [28, 31]. …”

Section: The Human Eye and The Oxidative Stressmentioning

confidence: 99%

“…DHA comprises 40% of the polyunsaturated fatty acids (PUFAs) in the brain and 60% of the lipid constituents of the membrane of the retinal photoreceptors; in humans, DHA is obtained from the diet [28, 32]. Also, DHA may be converted from eicosapentaenoic acid (EPA) but this synthesis involves several steps including elongation and peroxisomal beta-oxidation [33].…”

Section: The Human Eye and The Oxidative Stressmentioning

confidence: 99%

“…Although the exact pathogenesis of AMD is not known, oxidative stress is considered to be involved as the human eye, and particularly the retina is exposed to the production of free radicals leading to a prooxidative environment [28]. This vulnerability is related to several factors: (a) the high vascularization, which results in high oxygen tension; (b) the light-induced stress in fovea due to the increased cellular density and metabolism; (c) the retinal tissues that present high quantity of unsaturated fatty acids and photosensitizing compounds, which are highly susceptible to oxidation; (d) the exposition of the retina to cumulative radiation [24, 28, 41].…”

Section: Pathogenesis Of Amd and Oxidative Stressmentioning

confidence: 99%

“…It is, therefore conceivable that dietary antioxidants and/or supplements may be beneficial to preventing and/or delaying the progression of AMD due to the decrease of oxidative stress and reduction of inflammatory events [28]. …”

Section: Pathogenesis Of Amd and Oxidative Stressmentioning

confidence: 99%

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Nutritional and Lifestyle Interventions for Age‐Related Macular Degeneration: A Review

Carneiro

Andrade

2017

Oxidative Medicine and Cellular Longevity

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Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. In this narrative review, we will summarize the nutritional interventions evaluated in numerous observational studies and a few randomized clinical trials. The AREDS and AREDS2 studies demonstrated that supplements including vitamins C and E, beta-carotene, and zinc may reduce the progression to advanced AMD, in some patients, by 25% in five years. This is one of the few nutritional supplements known to have beneficial effects in any eye disease. Lutein/zeaxanthin supplementation may have beneficial effects in some individuals whereas omega-3 fatty acids supplementation needs to be further investigated and supported by more evidence. Genetic factors may explain the different patterns of response and explain differences found among individuals. More importantly, a combination of lifestyle behaviors such as the avoidance of smoking, physical activity, and the adoption of a healthy dietary pattern like the Mediterranean diet was associated with a lower prevalence of AMD. The adoption of these lifestyles may reduce the prevalence of the early stages of AMD and decrease the number of individuals who develop advanced AMD and consequently the onerous and climbing costs associated with the treatment of this disease.

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Section: The Human Eye and The Oxidative Stressmentioning

confidence: 99%

Section: The Human Eye and The Oxidative Stressmentioning

confidence: 99%

Section: The Human Eye and The Oxidative Stressmentioning

confidence: 99%

Section: Pathogenesis Of Amd and Oxidative Stressmentioning

confidence: 99%

Section: Pathogenesis Of Amd and Oxidative Stressmentioning

confidence: 99%

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Nutritional and Lifestyle Interventions for Age‐Related Macular Degeneration: A Review

Carneiro

Andrade

2017

Oxidative Medicine and Cellular Longevity

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Nahrungsergänzungsmittel und „Lifestyle“

Christof

Gamulescu

2019

Klin Monatsbl Augenheilkd

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ZusammenfassungAktuell ist eine Therapie der nicht exsudativen altersabhängigen Makuladegeneration (AMD) – im Gegensatz zu der exsudativen Form – nicht möglich. Eine präventive Wirkung und ein verlangsamtes Fortschreiten der Erkrankung erhoffen sich viele Betroffene von den sich auf dem Markt befindenden Nahrungsergänzungsmitteln. Die darin enthaltenen Stoffe sollen das oxidative Milieu im Bereich der äußeren Netzhaut reduzieren und so den Zellschaden und damit die Progression der AMD verlangsamen. Die ARED-Studien (ARED: Age-Related Eye Disease) untersuchten bestimmte dieser Nahrungsergänzungsmittel auf ihre Wirksamkeit, das Risiko des Fortschreitens der AMD in die Spätformen zu vermindern. Sie sind die einzigen interventionellen groß angelegten, prospektiven, randomisierten und kontrollierten klinischen Studien und werden immer wieder als Basis für die Nahrungsergänzung bei der AMD herangezogen. In diesem Artikel soll die Rationale für die Verwendung bestimmter Inhaltsstoffe der AREDS-Nahrungsergänzungsmittel besprochen und die Ergebnisse der ARED-Studien kritisch beleuchtet werden. Weiterhin soll der moderne Begriff des „Lifestyle“ im Kontext der AMD als weitere Möglichkeit der Einflussnahme jedes Einzelnen auf die Progression der Erkrankung thematisiert und diskutiert werden.

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The Role of Omega-3 and Antioxidant Nutrients in Age-Related Macular Degeneration: A Review Article

Koçyiğit

Tek

2022

Clinical and Experimental Health Sciences

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Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss worldwide. The cause of the disease is not well explained; studies previse a multifactorial etiology. Various results of studies suggest that omega-3 fatty acids may have beneficial effects in AMD. Besides the omega-3, clinical evidence showed that specific micronutrients (antioxidant vitamins and minerals) protect against AMD. The definition of risk factors for the development and progression of AMD is important for understanding the causes of the disorder and for the determination of its prevention strategies. In this study, the relationship between omega 3 and antioxidant nutrients and the incidence and progression of AMD were evaluated.

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Nutrition and the ageing eye

Cited by 3 publications

References 107 publications

Nutritional and Lifestyle Interventions for Age‐Related Macular Degeneration: A Review

Nutritional and Lifestyle Interventions for Age‐Related Macular Degeneration: A Review

Nahrungsergänzungsmittel und „Lifestyle“

The Role of Omega-3 and Antioxidant Nutrients in Age-Related Macular Degeneration: A Review Article

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