Nutrition and vascular dementia

Perez, Leandro; Helm, Lena; Sherzai, Ayesha; Jaceldo‐Siegl, Karen

doi:10.1007/s12603-012-0042-z

Cited by 54 publications

(28 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The protective effect of fish intake against cerebral vascular disease risk (including stroke and VCI) is established [64,65]. Although, omega-3 fatty acids (docosahexaenoic acid and eicosapentaenoic acid) in fish have been largely implicated in the protection, other nutritional constituents of fish including vitamins D and B complex, essential amino acids and trace elements in fish (for example, taurine, arginine, selenium, calcium, magnesium, potassium, and iodine) may have potentially favorable effects on inflammation, endothelial function, vascular tone, neuronal functioning and cell death [65,66].…”

Section: Discussionmentioning

confidence: 99%

Profile and determinants of vascular cognitive impairment in African stroke survivors: The CogFAST Nigeria Study

Akinyemi

Allan

Owolabi

et al. 2014

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Profile and determinants of vascular cognitive impairment in African stroke survivors: The CogFAST Nigeria Study

Akinyemi

Allan

Owolabi

et al. 2014

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…A diet rich in saturated fat is associated with faster cognitive decline and increased risk of dementia [72,78]. On the contrary, fish consumption, rich in omega-3 polyunsaturated fatty acids has been shown as protective against cognitive decline [78].…”

Section: Cognitive Functionmentioning

confidence: 99%

EMAS position statement: Diet and health in midlife and beyond

Lambrinoudaki¹,

Ceasu²,

Depypere³

et al. 2013

Maturitas

View full text Add to dashboard Cite

“…This subsequently produces of S-adenosylmethionine (SAM), which plays a role in neurotransmitter synthesis and lipid metabolism [1]. Folate deficiency results in elevated levels of plasma homocysteine, which have been associated with cardiovascular disease [2], neurodegeneration [3], impaired cognitive function [4,5], the development of Alzheimer's disease (AD) [6][7][8], and vascular dementia [9][10][11]. However, the neurodegeneration link remains controversial, since other studies have shown no association [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil–DNA glycosylase impair learning in a mouse model of vascular cognitive impairment

Jadavji

Farr

Lips

et al. 2015

Behavioural Brain Research

View full text Add to dashboard Cite

(2015) Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural Brain Research, 283 . pp. 215-226. ISSN 1872-7549 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/32983/9/UNG_FADD_20140826_manuscript_final.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. ABSTRACTDietary deficiencies in folic acid result in elevated levels of plasma homocysteine, which has been associated with the development of dementia and other neurodegenerative disorders.Previously, we have shown that elevated levels of plasma homocysteine in mice deficient for a DNA repair enzyme, uracil-DNA glycosylase (UNG), result in neurodegeneration. The goal of this study was to evaluate how deficiencies in folic acid and UNG along with elevated levels of homocysteine affect vascular cognitive impairment, via chronic hypoperfusion in an animal model. Ung+/+ and Ung−/− mice were placed on either control (CD) or folic acid deficient (FADD) diets. Six weeks later, the mice either underwent implantation of microcoils around both common carotid arteries. Post-operatively, behavioral tests began at 3-weeks, angiography was measured after 5-weeks using MRI to assess vasculature and at completion of study plasma and brain tissue was collected for analysis. Learning impairments in the Morris water maze (MWM) were observed only in hypoperfused Ung−/− FADD mice and these mice had significantly higher plasma homocysteine concentrations. Interestingly, Ung+/+ FADD produced significant remodeling of the basilar artery and arterial vasculature. Increased expression of GFAP was observed in the dentate gyrus of Ung−/− hypoperfused and FADD sham mice. Chronic hypoperfusion resulted in increased cortical MMP-9 protein levels of FADD hypoperfused mice regardless of genotypes. These results suggest that elevated levels of homocysteine only, as a result of dietary folic acid deficiency, don't lead to memory impairments and neurobiochemical changes. Rather a combination of either chronic hypoperfusion o...

show abstract

Nutrition and vascular dementia

Cited by 54 publications

References 41 publications

Profile and determinants of vascular cognitive impairment in African stroke survivors: The CogFAST Nigeria Study

Profile and determinants of vascular cognitive impairment in African stroke survivors: The CogFAST Nigeria Study

EMAS position statement: Diet and health in midlife and beyond

Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil–DNA glycosylase impair learning in a mouse model of vascular cognitive impairment

Contact Info

Product

Resources

About