Nutrition and wound healing

Brown, Katherine L.; Phillips, Tania J.

doi:10.1016/j.clindermatol.2010.03.028

Cited by 74 publications

(49 citation statements)

References 66 publications

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“…We identified a cnidarian-specific gene (thiamine synthesis enzyme), an enzyme utilized during the synthesis of vitamin B, a deficiency of which has been linked to wound healing defects [66]. This gene is found on scaffold 466 in the Nematostella genome, was represented in expressed sequence tag resources utilized in genome construction [8], and was confirmed to be highly up-regulated after puncture injury by qPCR and in situ hybridization (Figures 4, 5 and 6).…”

Section: Discussionmentioning

confidence: 99%

Initiating a regenerative response; cellular and molecular features of wound healing in the cnidarian Nematostella vectensis

2014

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BackgroundWound healing is the first stage of a series of cellular events that are necessary to initiate a regenerative response. Defective wound healing can block regeneration even in animals with a high regenerative capacity. Understanding how signals generated during wound healing promote regeneration of lost structures is highly important, considering that virtually all animals have the ability to heal but many lack the ability to regenerate missing structures. Cnidarians are the phylogenetic sister taxa to bilaterians and are highly regenerative animals. To gain a greater understanding of how early animals generate a regenerative response, we examined the cellular and molecular components involved during wound healing in the anthozoan cnidarian Nematostella vectensis.ResultsPharmacological inhibition of extracellular signal-regulated kinases (ERK) signaling blocks regeneration and wound healing in Nematostella. We characterized early and late wound healing events through genome-wide microarray analysis, quantitative PCR, and in situ hybridization to identify potential wound healing targets. We identified a number of genes directly related to the wound healing response in other animals (metalloproteinases, growth factors, transcription factors) and suggest that glycoproteins (mucins and uromodulin) play a key role in early wound healing events. This study also identified a novel cnidarian-specific gene, for a thiamine biosynthesis enzyme (vitamin B synthesis), that may have been incorporated into the genome by lateral gene transfer from bacteria and now functions during wound healing. Lastly, we suggest that ERK signaling is a shared element of the early wound response for animals with a high regenerative capacity.ConclusionsThis research describes the temporal events involved during Nematostella wound healing, and provides a foundation for comparative analysis with other regenerative and non-regenerative species. We have shown that the same genes that heal puncture wounds are also activated after oral-aboral bisection, indicating a clear link with the initiation of regenerative healing. This study demonstrates the strength of using a forward approach (microarray) to characterize a developmental phenomenon (wound healing) at a phylogenetically important crossroad of animal evolution (cnidarian-bilaterian ancestor). Accumulation of data on the early wound healing events across numerous systems may provide clues as to why some animals have limited regenerative abilities.

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Section: Discussionmentioning

confidence: 99%

Initiating a regenerative response; cellular and molecular features of wound healing in the cnidarian Nematostella vectensis

2014

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“…Resistance to stress during periods of parental care also has been widely documented in mammalian and avian taxa, and is thought to be an adaptive response to increase current reproductive fitness (Astheimer et al, 2000;Wingfield and Sapolsky, 2003). The lack of impact of nutritional condition on parental behaviours was unexpected, as supplemental feeding during the reproductive period has been shown to widely influence parental care behaviours in a variety of taxa (Boutin, 1990;Hogstedt, 1981;Schreck et al, 2001;Brown et al, 2010). In avian species, supplemental feeding has been shown to increase parental nest presence, egg incubation time and parental aggression towards nest predators (Dewey and Kennedy, 2001;Lothery et al, 2014;Markman, 2014).…”

Section: Discussionmentioning

confidence: 99%

Stress, nutrition and parental care in a teleost fish: Exploring mechanisms with supplemental feeding and cortisol manipulation

Zolderdo

Algera

Lawrence

et al. 2016

Journal of Experimental Biology

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Parental care is an essential life-history component of reproduction for many animal species, and it entails a suite of behavioural and physiological investments to enhance offspring survival. These investments can incur costs to the parent, reducing their energetic and physiological condition, future reproductive capabilities and survival. In fishes, relatively few studies have focused on how these physiological costs are mediated.

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“…The absence of nutrients, such as fatty acids, in the skin can lead to altered cell proliferation and maintenance and decreased ECM production, ultimately contributing to non-healing skin conditions such as ulcers (Arnold and Barbul, 2006;Brown and Phillips, 2010). By defining the role of adipocyte lineage cells in the skin, we have identified that these cells dynamically promote skin wound healing.…”

Section: Diabetes May Influence Fibroblast Function During Skin Woundmentioning

confidence: 99%

Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

2013

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SUMMARYAcute wound healing in the skin involves the communication of multiple cell types to coordinate keratinocyte and fibroblast proliferation and migration for epidermal and dermal repair. Many studies have focused on the interplay between hematopoietic cells, keratinocytes and fibroblasts during skin wound healing, yet the possible roles for other cell types within the skin, such as intradermal adipocytes, have not been investigated during this process. Here, we identify that adipocyte lineage cells are activated and function during acute skin wound healing. We find that adipocyte precursor cells proliferate and mature adipocytes repopulate skin wounds following inflammation and in parallel with fibroblast migration. Functional analysis of mice with defects in adipogenesis demonstrates that adipocytes are necessary for fibroblast recruitment and dermal reconstruction. These data implicate adipocytes as a key component of the intercellular communication that mediates fibroblast function during skin wound healing.

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Nutrition and wound healing

Cited by 74 publications

References 66 publications

Initiating a regenerative response; cellular and molecular features of wound healing in the cnidarian Nematostella vectensis

Initiating a regenerative response; cellular and molecular features of wound healing in the cnidarian Nematostella vectensis

Stress, nutrition and parental care in a teleost fish: Exploring mechanisms with supplemental feeding and cortisol manipulation

Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

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