Nutrition, dietary interventions and prostate cancer: the latest evidence

Abstract

Prostate cancer (PCa) remains a leading cause of mortality in US men and the prevalence continues to rise world-wide especially in countries where men consume a ‘Western-style’ diet. Epidemiologic, preclinical and clinical studies suggest a potential role for dietary intake on the incidence and progression of PCa. 'This minireview provides an overview of recent published literature with regard to nutrients, dietary factors, dietary patterns and PCa incidence and progression. Low carbohydrates intake, soy protein, omega-3 (w-3) fat, green teas, tomatoes and tomato products and zyflamend showed promise in reducing PCa risk or progression. A higher saturated fat intake and a higher β-carotene status may increase risk. A ‘U’ shape relationship may exist between folate, vitamin C, vitamin D and calcium with PCa risk. Despite the inconsistent and inconclusive findings, the potential for a role of dietary intake for the prevention and treatment of PCa is promising. The combination of all the beneficial factors for PCa risk reduction in a healthy dietary pattern may be the best dietary advice. This pattern includes rich fruits and vegetables, reduced refined carbohydrates, total and saturated fats, and reduced cooked meats. Further carefully designed prospective trials are warranted.

Reconstruction of NK Cells During Complex Cancer Treatment

“…In the glucan-supplemented group, only small change was found, but in the placebo group we found significant weight reduction. In a short term of evaluation, we do not consider nutritional changes as significant [8] , despite the desperate need for a weight decrease in patients with high BMI [17] . Our findings showed the same dynamic of changes in levels of leptin -nonsignificant changes in the glucansupplemented group, stronger (but still statistically nonsignificant) decrease in the placebo group.…”

“…Starting points of cancer disease are closely associated with obesity [2,8] . These processes are manifested by induction of inflammatory proteins with characteristic long-term inflammation and are mostly induced via adipocytes producing various proteins involved in inflammation [13,14] .…”

“…Supplementation with vitamins, minerals and other supporting materials is often used in many malignant diseases [8,22,23] . With more than 14 000 scientific publications, it is not surprising that glucan is the most commonly used natural immunomodulatory [23,26] .…”

“…It is imperative to not only maintain high quality nutrition and to eliminate stress, but also tofulfill the feeling of necessity of taking care of its own health. It will result in reaching the optimal level of immune reactions necessary for reparation of physiological functions [1,8,[23][24][25] .…”

“…The most commonly obesity-related diseases are cardiovascular diseases, type II diabetes and some malignant diseases [2,5,6] . Recently, the focus of intensive studies is on the relation between increased weight and a higher risk of cancer development [7,8] . Numerous research studies evaluated several components of the immune response for possible relations to the cancer development.…”