Nutrition during childhood cancer treatment: current understanding and a path for future research

Joffe, Lenat; Ladas, Elena J.

doi:10.1016/s2352-4642(19)30407-9

Cited by 57 publications

(69 citation statements)

References 80 publications

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“…Abnormal body composition together with impaired micronutrient status may impact resilience to the disease process as well as to treatment directly. Variations in body composition might have adverse effects on action and metabolism of chemotherapeutics 28 . Childhood cancer patients presenting with malnutrition have worse survival.…”

Section: Discussionmentioning

confidence: 99%

Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins

Yaprak

Yalçın

Pınar

et al. 2020

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins

Yaprak

Yalçın

Pınar

et al. 2020

Pediatric Blood & Cancer

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“…Micronutrient laboratory analyses in children with various malignancies have revealed a high frequency of deficiencies in vitamins C, D and zinc [11]. In addition, malnutrition presenting as obesity is a risk factor for cancer-related late effects such as cardiovascular disease, metabolic syndrome, osteoporosis, and Type II diabetes mellitus [8]. To date, there is no universally accepted approach to nutritional support for children with cancer [15].…”

Section: Introductionmentioning

confidence: 99%

“…Decelerated physical growth (height and weight), obesity, micronutrient deficiencies and sarcopenia are not universally appreciated or addressed by pediatric oncology health care providers. Significant gaps exist in our understanding of the mechanisms of these malnourished states and there are no evidence-based guidelines for how to prevent or treat them [8]. To date, the development of dietary guidelines has been hampered by a lack of high-quality clinical trials that include nutritional variables, interventions, and endpoints in pediatric cancer patients and survivors.…”

Section: Introductionmentioning

confidence: 99%

“…No deleterious effects of exercise interventions have been found in these children [26]. Regardless, there are no generally accepted exercise recommendations for pediatric cancer patients, and evidence for the optimal timing, modality, frequency and intensity of exercise is lacking [8].…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, in children and AYA with cancer, malnutrition—including both over and undernutrition—is a risk factor for inferior cancer-related outcomes [ 4 ] and PA is associated with improved quality of life and physical function [ 5 ]. There are also emerging preclinical data that suggest that PA may improve tumor response to treatment [ 6 , 7 ] and that obesity may reduce tumor response to treatment via adipocyte signaling [ 8 ]. Both the intake and expenditure aspects of the EB equation as they relate to cancer outcomes will be reviewed briefly below.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility and Acceptability Findings of an Energy Balance Data Repository of Children, Adolescents, and Young Adults with Cancer

Swartz

Teague

Wells

et al. 2020

JCM

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Cancer patients suffer changes in energy balance (EB), the combination of energy intake (nutrition) and energy expenditure (physical activity (PA)), which may influence cancer-related morbidity, mortality, and quality of life. Significant gaps remain in our understanding of the frequency and magnitude of these EB changes. Herein, we report on the feasibility and acceptability of a longitudinal repository of EB outcomes in children, adolescents and young adults (AYA) with cancer along the cancer continuum to fill these gaps. This EB repository includes PA, nutrition, and physical function (PF) parameters. PA data were gathered through activity trackers. Nutritional data were gathered through food diaries and micronutrient labs. PF was assessed with validated objective and patient-reported measures. Feasibility was achieved with >50% enrollment of eligible patients (n = 80, Mage = 18.1 ± 7.5); 26 were children with cancer and 54 were AYAs with cancer. An 88.75% retention rate indicated acceptability. Despite COVID-19 disruptions, >50% of participants provided completed data for PA and micronutrient labs as of April 2020. Food diaries and PF data collection experienced disruptions. Methodological adaptations are in progress to minimize future disruptions. Overall, our findings demonstrate that prospective EB assessments are feasible and acceptable among children and AYAs with cancer.

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Validity of a nutrition screening tool for childhood cancer

Kangalgil,

Meral,

Murphy Alford

et al. 2024

Nut in Clin Prac

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BackgroundMalnutrition in pediatric oncology patients is a serious clinical condition. There is a need for standardized nutrition screening in pediatric oncology patients, as nutrition screening can offer a simple method to identify children with cancer at risk of malnutrition. This study aimed to determine the validity of a Turkish version of nutrition screening tool for childhood cancer (SCAN) in identifying the risk of malnutrition among children with cancer.Materials and MethodsA cross‐sectional study was conducted with 78 children with cancer admitted to the pediatric hematology‐oncology unit of a university hospital. In the first stage of this study, SCAN was translated into Turkish, and in the second stage, the validity of SCAN against pediatric Subjective Global Nutritional Assessment (SGNA) and Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition (AND/ASPEN) malnutrition criteria were evaluated.ResultsPatients had a median age of 8.0 years (range, 2–18 years; IQR, 5–14 years), 61.5% were male, and 60.3% were diagnosed with leukemia. According to SCAN, 53.8% had high risk of malnutrition. Validation of SCAN against pediatric SGNA showed that SCAN has a sensitivity of 97.5%, specificity of 94.5%, and accuracy of 96.1%.ConclusionThe risk of malnutrition is common in children with cancer. The Turkish version of the SCAN is a simple, quick, and valid tool to determine the risk of malnutrition in children with cancer. Further research is needed to understand the impact of nutrition interventions on clinical outcomes in children at risk for malnutrition based on SCAN.

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Nutrition during childhood cancer treatment: current understanding and a path for future research

Cited by 57 publications

References 80 publications

Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins

Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins

Feasibility and Acceptability Findings of an Energy Balance Data Repository of Children, Adolescents, and Young Adults with Cancer

Validity of a nutrition screening tool for childhood cancer

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