Nutrition, Epigenetics, and Metabolic Syndrome

Wang, Junjun; Wu, Zhenlong; Li, Defa; Li, Ning; Dindot, Scott V.; Satterfield, M. Carey; Bazer, Fuller W.; Wu, Guoyao

doi:10.1089/ars.2011.4381

Cited by 227 publications

(139 citation statements)

References 212 publications

(288 reference statements)

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“…Based on the foregoing lines of compelling evidence from animal and human studies, Wu (2010) proposed the new concept of functional AA, which are defined as those AA that participate in and regulate key metabolic pathways to improve health, survival, growth, development, lactation, and reproduction of the organisms. Metabolic pathways include: (1) intracellular protein turnover (synthesis and degradation) and associated events (Bertrand et al 2012;Kong et al 2012;Wauson et al 2013;Xi et al 2011Xi et al , 2012Yao et al 2012), (2) AA synthesis and catabolism (Brosnan and Brosnan 2012;Lei et al 2012a, b), (3) generation of small peptides, nitrogenous metabolites, and sulfur-containing substances [e.g., H 2 S (Mimoun et al 2012)], (4) urea cycle and uric acid synthesis (Wu 2013), (5) lipid and glucose metabolism Go et al 2012;Satterfield et al 2011Satterfield et al , 2012, (6) one-carbon unit metabolism (Wang et al 2012), and (7) cellular redox signaling (Hou et al 2012a). Functional AA can be nutritionally ''essential'', ''nonessential'', or conditionally essential AA (Table 1).…”

Section: Metamorphosis Of Fishmentioning

confidence: 99%

“…Furthermore, these AA, along with glycine, tryptophan, tyrosine and D-amino acids (e.g., D-alanine, D-aspartate, and D-serine), regulate neurological development and function (Fernstrom 2012;Friedman and Levin 2012;Hou et al 2012a, b;Wang et al 2013). Moreover, leucine activates the mammalian target of rapamycin to stimulate protein synthesis and inhibit intracellular proteolysis (Dillon 2012;Li et al 2011b), whereas methionine is the major donor of the methyl group to affect DNA and protein methylation in cells (Wang et al 2012). Notably, nutritional studies have shown that dietary supplementation with several AA (e.g., arginine, glutamine, glutamate, leucine, and proline) modulates gene expression and enhances growth of the small intestine and skeletal muscle (Geng et al 2011;Jobgen et al 2009;Wang et al 2008;Wu et al 2011a, b; Regulation of acid-base balance (e.g., renal ammoniagenesis from glutamine)…”

Section: Introductionmentioning

confidence: 99%

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Functional amino acids in nutrition and health

2013

Amino Acids

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Section: Metamorphosis Of Fishmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional amino acids in nutrition and health

2013

Amino Acids

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615

425

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“…However, the metabolism of other amino acids (serine, glycine and histidine) also plays an important role in provision of methyl donors for DNA and histone methylation (Wang et al, 2012). However, neither methionine nor other amino acids are considered dietary factors that could affect the predisposition to suffer from obesity.…”

Section: Fatty Acid and Amino Acidsmentioning

confidence: 99%

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro

Mansego

Miguel

et al. 2013

Molecular Aspects of Medicine

257

161

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Nutritional factors play a life-long role in human health. Indeed, there is growing evidence that one of the mechanisms by which nutrients and bioactive compounds affect metabolic traits is epigenetics. Complex interactions among food components and histone modifications, DNA methylation, non-coding RNA expression and chromatin remodeling factors lead to a dynamic regulation of gene expression that controls the cellular phenotype. Although perinatal period is the time of highest phenotypic plasticity, contributing largely to developmental programming, also during adulthood there is evidence about a nutritional influence on epigenetic regulation. Similarly to type 2 diabetes, hypertension, atherosclerosis and other metabolic disorders, obesity predisposition and weight loss outcomes have been repeatedly associated to changes in epigenetic patterns. Different non-nutritional risk factors that usually accompany obesity seem also to be involved in these epigenetic modifications, especially hyperglycemia, inflammation, hypoxia and oxidative stress. There are currently three major objectives in epigenetic research in relation to obesity: to search for epigenetic biomarkers to predict future health problems or detect the individuals at most risk, to understand the obesity-related environmental factors that could modulate gene expression by affecting epigenetic mechanisms, and to study novel therapeutic strategies based on nutritional or pharmacological agents that can modify epigenetic marks. At this level, the major tasks are: development of robust epigenetic biomarkers of weight regulation, description of those epigenetic marks more susceptible to be modified by dietary exposures, identification of the active ingredients (and the doses) that alter the epigenome, assessment of the real importance of other obesity-related factors on epigenetic regulation, determination of the period of life in which best results are obtained, and understanding of the importance of the inheritance of these epigenetic marks.

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“…The severity of Non-alcoholic fatty liver disease (NAFLD) induced by a choline-and folate-deficient diet in mice is associated with altered expression of hepatic miRNAs, including miR-181a, miR-34a, miR-200b, and miR-221 [56]. Moreover, maintenance and regulation of the epigenetic state which depends on (1C) metabolism require adequate provision of B vitamins (including folate, vitamin B6 and vitamin B12), glycine, methionine, serine, choline, histidine, and creatine [57]. These nutrients play an important role in regulating the availability of S-adenosyl-methionine (a major methyl donor for DNA and protein methylation by specific [58].…”

Section: Folic Acid (Folate)mentioning

confidence: 99%

Tasks of some dietary essential nutrients on epigenetics and one carbon metabolism in livestock during production

Yusuf¹,

Elsayed²,

Hashish³

et al. 2016

IOSR

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: Interchanges in the epigenome caused by the environment have been cited in multiple animal being, ranging from insects to rodents passing through poultry, larger animals, and nonhuman primates to humans. These include DNA methylation, chromatin remodeling, histone modifications, and more recently the index has magnified to incorporate noncoding RNAs and microRNA gene regulation. Thus, it is increasingly accepted that, nutrition one of the factors that alter gene expression and affect's health during animal productivity through epigenetic modification. DNA methylation is the most widely studied form of epigenetic modification and occurs within the one-carbon metabolism tract which is dependent upon a number of enzymes in the presence of micronutrients, including folate, choline, and betaine acquired through the diet. In vertebrates DNA methylation is primarily a stable repressive mark built at cytosines in CpG dinucleotides; however, its regulation is more powerful than previously believed. Nutri-Epigenomic is an emerging discipline examining the role of nutrient on gene expression. Ultimately, DNA methylation and other epigenetic status, as well as dietetic practices, particularly micronutrient intake, may influence health and productive phenotypes, also playing as significant biomarker in additive-benefit assessment during the period of use. There are a tight interrelationship betaine, choline and methionine. All are dietary sources of methyl groups made it prominent when studying diet-DNA methylation. In this review, our team will focus on the role of important methyl donors and nutrient-gene inter actions through the one-carbon metabolism.

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Nutrition, Epigenetics, and Metabolic Syndrome

Cited by 227 publications

References 212 publications

Functional amino acids in nutrition and health

Functional amino acids in nutrition and health

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Tasks of some dietary essential nutrients on epigenetics and one carbon metabolism in livestock during production

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