Nutrition Evidence-Based Guidelines for Treating Hyperlipidemia in Children With Type 1 Diabetes

Robinson, Megan

doi:10.1177/0145721708328597

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…Cholesterol feeding has been often used to elevate serum or tissue cholesterol levels to assess hypercholesterolemia-related metabolic disturbances in different animal models. [1,2,19] Rats fed with a diet supplemented with cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal laboratory feed for 30 days served as the experimental model. This is in accord with the previous finding reported by Yoon et al, 2008, who showed that feeding rats with high cholesterol diet (HCD) for 7 days induced hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

“…About 20% reduction of blood cholesterol level can decrease about 31% of CHD incidence and 33% of its mortality rate. [2][3][4][5][6] Lipids play out some significant capacities in body. In addition, hyperlipidemia is induced by secondary effect of diabetes; therefore, the agent having some antioxidant and antidiabetic effect also showed favorable effect to hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

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Vasantha¹

2020

IJGP

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Background: Hypercholesterolemia is the state depicted by expanded greasy substances called lipids, rise in plasma total cholesterol (TC) and triglyceride (TG) levels, it is additionally called hyperlipoproteinemia. Materials and Methods: The present study was designed to investigate the hypolipidemic effect of ethanolic extract of Macrotyloma uniflorum leaves and stems (EMULS) in high-fat diet (cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal laboratory feed) induced hyperlipidemia. EMULS was administered in three doses of 100 mg/kg/day p.o., 200 mg/kg/day p.o, and 400 mg/kg/day p.o each for 30 days. Results: Simultaneous administration of EMULS significantly (P < 0.01) prevents the rise in serum levels of Total Cholesterol (TCs), Triglycerides (TGs), Low Density Lipoprotein Cholesterol (LDL-C) and Very Low Density Lipoprotein Cholesterol (VLDL-C) whereas significant (p<0.05) increases in the level of High Density Lipoprotein Cholesterol (HDL-C). Conclusion: Based on the results we conclude the use of leaves and stems extract of Macrotyloma uniflorum has preventive and curative effect against hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Untitled

Vasantha¹

2020

IJGP

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“…A 20% reduction of blood cholesterol level can decrease by about 31% of CHD incidence, and 33% of its mortality rate. [2][3][4][5][6] Lipids play out some significant capacities in the body. Also, hyperlipidemia is induced by the secondary effect of diabetes.…”

Section: Abstract a R T I C L E I N F Omentioning

confidence: 99%

Evaluation of Antihyperlipidemic Activity of Ethanolic Extract of Crossandra Infundibuliformis Leaves and Stems on High Fat Diet Induced Hyperlipidemia

Vasantha

Allenki

Dayakar³

2020

Int. J. Pharm. Sci. Drug Res.

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Hypercholesterolaemia is the state been depicted by an expanded greasy substances called lipids, rise in plasma TCs and TGs levels it is additionally called hyper lipoproteinemia. The present study was designed to investigate the hypolipidemic effect of ethanolic extract of Crossandra infundibuliformis leaves and stem (ECILS) in high fat diet (cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal laboratory feed) . The rats feed with High-fat diet containing (cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal standard laboratory feed) for 1 month, and then they are checked for the blood parameter levels like TC, TGs, LDL, VLDL, and HDL. Ethanolic extracts at low dose (100 mg/kg), significantly reduced the levels of TC, TGL, LDL, VLDL & increased the levels of HDL and reduced the body weights on 30st day, and at medium, high doses it reduced the levels of TC, TGL, LDL, VLDL & increased the levels of HDL and reduced the body weights.

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“…33,34 Hyperlipidemia is defined in children and adolescents with diabetes as having a LDL greater than 100 mg/dL. 35 Children with double diabetes are also at risk for having low HDL of less than 40 mg/dL and a TG level greater than 100 mg/dL in children younger than 10 years, and greater than 130 mg/dL in children aged 10 to 19 years. 25 Medical nutrition therapy for abnormal lipids has been well documented to reduce LDL cholesterol by 30%.…”

Section: Hyperlipidemiamentioning

confidence: 99%

Defining Double Diabetes in Youth

Robinson

Estell

2012

Topics in Clinical Nutrition

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The prevalence of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in youth is on the rise. The increased incidence of obesity makes classifying diabetes difficult. At diagnosis, most young people present with characteristics of either T1DM or T2DM. Young people with double diabetes are obese, insulin resistant and have the immunological markers of T1DM. The appropriate markers must be used to identify double diabetes. Complications of double diabetes include abnormal lipids, polycystic ovary syndrome, hypertension, vitamin D inadequacy, and increased cardiovascular risk. Medical nutrition therapy is vital to the treatment and prevention of double diabetes and its complications.A PPROXIMATELY 1 in 400 children and adolescents younger than 20 years has diabetes, categorizing diabetes as the third most common chronic disease in childhood. 1,2 The prevalence of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) is on the rise. According to the EURODIAB (a collaborative European study of issues around diabetes) group, the incidence of T1DM has increased by 3.2% annually over the past several decades; especially in children younger than 5 years. 3 This increase has suggested a relationship to environmental changes rather than genetic, due to the short period of time of increased incidence. Furthermore, the multicenter, population-based SEARCH, a multicenter study to understand more about diabetes in young adults and children that is conducted in the United States, determined the incidence of T1DM in Colorado youth increased by 2.7% per year in the non-Hispanic white population and 1.6% per year in Hispanic youth. 4 The largest increase was seen in children aged 0 to 4 years (3.5% per year), similar to the European data.The incidence of T2DM in the pediatric population has increased 10-fold over the past 10 years resulting in 3700 new cases per year related to obesity and sedentary lifestyle. 5 It is projected that more than 30% of children born in the year 2000 will develop diabetes during their lifetime. 3 This high rate of T2DM is mainly seen in adolescents aged 15 to 19 years in minority populations. 6 Despite the rise in both types of diabetes, classifying T1DM and T2DM in the pediatric population is not straightforward. Research

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Nutrition Evidence-Based Guidelines for Treating Hyperlipidemia in Children With Type 1 Diabetes

Cited by 4 publications

References 27 publications

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Evaluation of Antihyperlipidemic Activity of Ethanolic Extract of Crossandra Infundibuliformis Leaves and Stems on High Fat Diet Induced Hyperlipidemia

Defining Double Diabetes in Youth

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