“…The spectrum and rate of onset of age-related impairments in function are largely dictated by the cumulative effects of genetic and epigenetic endowments, environmental, health, work, and lifestyle-related factors acquired across the lifetime of the animal. 5 Aging in otherwise healthy horses, as in other mammals, will inexorably lead to the eventual presentation of senescent changes. These changes include sarcopenia, the loss of body mass (BM), and the onset of organ dysfunction with progressive attrition of the dental, neural, immunologic, and other systems.…”