Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Roth‐Walter, Franziska; Berni Canani, Roberto; O'Mahony, Liam; Peroni, Diego; Sokolowska, Milena; Vassilopoulou, Emilia; Venter, Carina

doi:10.1111/all.15972

Cited by 16 publications

(2 citation statements)

References 443 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We assessed BMI but did not determine vitamin and mineral status in patients. Malnutrition in chronic disease, such as allergic disease and Irritable Bowel Disease, promotes inflammation and vice versa, 58,59 in which iron is playing a key role. 60 Malnutrition in EoE patients, specifically vitamin D deficiency, has been reported, although data are limited.…”

Section: Discussionmentioning

confidence: 99%

Dietary composition of adult eosinophilic esophagitis patients is related to disease severity

Eussen,

Wielders,

de Rooij

et al. 2024

Immunity Inflam & Disease

View full text Add to dashboard Cite

BackgroundIn addition to the elimination diet, dietary composition may influence disease severity in patients with eosinophilic esophagitis (EoE) through modulation of the immune response.AimTo explore the immunomodulatory role of nutrition before and during elimination diet in adult EoE patients.MethodsNutritional intake was assessed in 39 Dutch adult EoE patients participating in the Supplemental Elemental Trial (Dutch trial registry NL6014, NTR6778) using 3‐day food diaries. In this randomized controlled trial, diagnosed patients received either a four‐food elimination diet alone (FFED) or FFED with addition of an amino acid‐based formula for 6 weeks. Multiple linear regression analyses were performed to assess associations between the intake of nutrients and food groups per 1000 kCal and peak eosinophil count/high power field (PEC), both at baseline and after 6 weeks.ResultsAt baseline, we found a statistically significant negative (thus favorable) relationship between the intake of protein, total fat, phosphorus, zinc, vitamin B12, folate, and milk products and PEC (p < .05), while calcium (p = .058) and full‐fat cheese/curd (p = .056) were borderline (favorably) significant. In contrast, total carbohydrates, prepacked fruit juice, and white bread were significantly positively (unfavorable) related to PEC (p < .05), while ultra‐processed meals (p = .059) were borderline (unfavorably) significant. After dietary intervention, coffee/tea were significantly negatively (favorably) related to PEC, hummus/legumes were significantly positively (unfavorably) related with PEC, while peanuts were borderline significantly positively related (p = .058).ConclusionDietary composition may be related to inflammation in adult EoE patients. High‐quality and anti‐inflammatory diets may be a promising adjuvant therapy in the dietary management of EoE.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary composition of adult eosinophilic esophagitis patients is related to disease severity

Eussen,

Wielders,

de Rooij

et al. 2024

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

“…Sources of vitamin E in the diet include various common, specialty, and underutilized edible oils, as well as cereals, legume seeds, animal-derived products, wild plants, and edible flowers (Shahidi et al, 2021). Therefore, it is crucial to emphasize the consumption of these foods to maintain an adequate daily intake of vitamin E, as deficiencies in this nutrient can lead to inflammation (Roth-Walter et al, 2024). Several strengths characterize this study.…”

Section: Discussionmentioning

confidence: 99%

Causal role of vitamin E in atopic dermatitis risk: A Mendelian randomization study

Huang,

Zeng,

Yuan

2024

Food Science & Nutrition

View full text Add to dashboard Cite

Prior studies suggested that vitamin E might be beneficial in alleviating atopic dermatitis, but confirming a causal link was hindered by limitations such as sample sizes and unaccounted confounders. The present study aimed to clarify this through Mendelian randomization (MR) analysis. GWAS summary statistics was obtained from public databases encompassing a study on vitamin E and two studies related to atopic dermatitis. Two sets of instrumental variables (IVs) were selected using lenient (p < 1e‐5) and strict (p < 5e‐6) thresholds for separate MR analyses. Inverse variance weighted (IVW) was used as the primary MR method, supplemented by six additional MR methods, and followed by a meta‐analysis to consolidate the impact of vitamin E on atopic dermatitis from two independent studies. Furthermore, various sensitivity tests were performed to assess the reliability of the MR results. A meta‐analysis of IVW analyses deriving from two different atopic dermatitis cohorts under lenient IV selection thresholds demonstrated that vitamin E exhibited a significant lowering risk of atopic dermatitis effect (OR = 0.817, 95% CI: 0.673–0.991, p = .041), which was validated under strict IV selection thresholds (OR = 0.822, 95% CI: 0.709–0.954, p = .010). In addition, six other MR methods remained parallel to IVW (OR > 1). Multiple sensitivity tests showed that MR analyses were not affected by heterogeneity and horizontal pleiotropy. Overall, this MR study supported vitamin E reducing the risk of atopic dermatitis. Consequently, maintaining an adequate intake of vitamin E could potentially serve as an effective preventive measure against atopic dermatitis.

show abstract

Malnutrition in patients with obesity: An overview perspective

Cristancho,

Mogensen,

Robinson

2024

Nut in Clin Prac

View full text Add to dashboard Cite

Malnutrition in patients with obesity presents a complex and often overlooked clinical challenge. Although obesity is traditionally associated with overnutrition and excessive caloric intake, it can also coincide with varying degrees of malnutrition. The etiopathogenesis of obesity is multifaceted and may arise from several factors such as poor diet quality, nutrient deficiencies despite excess calorie consumption, genetics, and metabolic abnormalities affecting nutrient absorption and utilization. Moreover, a chronic low‐grade inflammatory state resulting from excess adipose tissue, commonly observed in obesity, can further exacerbate malnutrition by altering nutrient metabolism and increasing metabolic demands. The dual burden of obesity and malnutrition poses significant risks, including immune dysfunction, delayed wound healing, anemia, metabolic disturbances, and deficiencies in micronutrients such as vitamin D, iron, magnesium, and zinc, among others. Malnutrition is often neglected or not given enough attention in individuals with obesity undergoing rapid weight loss through aggressive caloric restriction, pharmacological therapies, and/or surgical interventions. These factors often exacerbate vulnerability to nutrition deficiencies. We advocate for healthcare practitioners to prioritize nutrition assessment and initiate medical intervention strategies tailored to address both excessive caloric intake and insufficient consumption of essential nutrients. Raising awareness among healthcare professionals and the general population about the critical role of adequate nutrition in caring for patients with obesity is vital for mitigating the adverse health effects associated with malnutrition in this population.

show abstract

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Cited by 16 publications

References 443 publications

Dietary composition of adult eosinophilic esophagitis patients is related to disease severity

Dietary composition of adult eosinophilic esophagitis patients is related to disease severity

Causal role of vitamin E in atopic dermatitis risk: A Mendelian randomization study

Malnutrition in patients with obesity: An overview perspective

Contact Info

Product

Resources

About