Nutrition, Inflammation, and Cognitive Function

Wärnberǵ, Julia; Gómez‐Martínez, Sonia; Romeo, Javier; Díaz, Lozano; Marcos, Ascensión

doi:10.1111/j.1749-6632.2008.03985.x

Cited by 105 publications

(87 citation statements)

References 127 publications

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“…Other inflammatory mediators have also been linked to cognitive dysfunction, including interleukin (IL)-6, IL-1b, tumour necrosis factor-a and a 1 -antichymotrypsin [12,13]. However, these studies suggest an association rather than a causal link [14].…”

Section: Mechanisms Of Cognitive Impairmentmentioning

confidence: 86%

“…Depressive symptoms are present in elderly people with cognitive impairment or dementia [80], but, while it is associated with impairment in executive function, memory and processing speed, it may account for only 1-2% of the variance in cognition in COPD [8,12]. In the NOTT trial the modest improvement in cognitive function was not associated with improvement in emotional or depressive symptoms [8].…”

Section: Depressionmentioning

confidence: 99%

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Cognitive function in COPD

Dodd¹,

Getov²,

Jones³

2010

Eur Respir J

360

364

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In order to characterise the overall clinical picture of chronic obstructive pulmonary disease (COPD) a better understanding of all relevant comorbidities is required. It is increasingly recognised that COPD is a multi-component disease, but little attention has been paid to its effects on cognitive function.Cognitive dysfunction is associated with increased mortality and disability; however, it remains poorly understood in COPD. This review examines mechanisms of injury and dysfunction to the brain and considers the methods used to evaluate cognition, and assembles evidence concerning the nature and level of cognitive impairment in COPD.Our main findings are: 1) there may be a pattern of cognitive dysfunction specific to COPD; 2) cognitive function is only mildly impaired in patients without hypoxaemia; 3) the incidence of cognitive dysfunction is higher in hypoxaemia; 4) hypoxaemia, hypercapnia, smoking and comorbidities (such as vascular disease) are unlikely to account for all of the cognitive dysfunction seen in COPD; 5) there is weak or no association between cognitive function and mood, fatigue or health status; 6) cognitive dysfunction may be associated with increased mortality and disability; and 7) there is limited evidence for a significant effect of treatment on cognitive function.

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Section: Mechanisms Of Cognitive Impairmentmentioning

confidence: 86%

Section: Depressionmentioning

confidence: 99%

Cognitive function in COPD

Dodd¹,

Getov²,

Jones³

2010

Eur Respir J

360

364

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“…One study found that levels of interleukins 1β (IL1β) correlated with adiposity and cognitive impairment (Erion et al, 2014). Inflammation, particularly chronic low-grade inflammation seems to affect several brain functions, from the early development of the brain to the development of neurodegenerative and psychiatric diseases, associated with cognitive deficits and dementia (Wärnberg, Gomez-Martinez, Romeo, Diaz, & Marcos, 2009). Another hypothesis focuses on the factors involved in arteriosclerosis and vascular factors involved in dementia.…”

Section: Discussionmentioning

confidence: 99%

Executive Functions Correlated with Body Mass Index in Overweight Middle-Aged Women

Solís¹,

Gutiérrez-Muñoz²,

Morado-Crespo³

et al. 2016

PSYCH

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The impacts of excess Body mass index (BMI) on physical health are well known and widely studied, but little is known about the consequences of being overweight or obese on cognitive function. The aim of this study was to correlate the BMI with executive functions in overweight middleaged women. Seventy overweight middle-aged women between 48 and 64 years of age who are otherwise healthy participated in the study. Demographic and anthropometric variables were evaluated. Four standard neuropsychological tests were applied to assess executive functions, sustained attention, selective attention, and verbal fluency. The mean BMI of the participants was 29.35 and was negatively correlated with categories reached (r = −0.41, p = 0.007) and positively correlated with the number of errors (r = 0.43, p = 0.005) of executive function test. Scores of other neuropsychological tests applied showed no correlation with BMI. These findings suggest that BMI impacts the executive functions in overweight women who do not present any signs of disease.

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“…Further covariates were selected based on the impact on cognition and inflammation in our sample as well as the current literature describing their effects on inflammation or cognitive function, such as depression, cardiovascular factors, metabolic factors and APOE genotype [36,37,38,39,40,41]. Depression was assessed by the 15-item Geriatric Depression Scale [42], which has been shown to be valid and to have excellent test/re-test reliability [43].…”

Section: Methodsmentioning

confidence: 99%

Systemic Inflammation Is Associated with MCI and Its Subtypes: The Sydney Memory and Aging Study

Trollor¹,

Smith

Baune

et al. 2010

Dement Geriatr Cogn Disord

108

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Background/Aims: Raised low-grade systemic inflammation has been associated with dementia, and preliminary studies suggest an association with mild cognitive impairment (MCI). This study examines the relationship between systemic inflammation and MCI subtypes. Methods: We measured the inflammatory markers C-reactive protein, interleukins (IL)-1β, -6, -8, -10 and -12, plasminogen activator inhibitor-1 (PAI-1), serum amyloid A (SAA), tumor necrosis factor-α (TNF-α) and vascular adhesion molecule-1 (VCAM-1) in the Sydney Memory and Ageing Study (MAS) cohort, a longitudinal study of 1,037 Australians aged 70–90 years. Results: After adjusting for possible confounding variables, levels of TNF-α and SAA were higher in participants with MCI compared to cognitively normal individuals, and some sex differences were apparent. Nonamnestic multiple domain MCI was associated with higher levels of IL-1β and IL-12, TNF-α and SAA compared to cognitively normal, amnestic MCI (single and multiple domain) and nonamnestic single domain MCI. PAI-1 levels were higher in cognitively normal and nonamnestic multiple domain MCI than in amnestic multiple domain MCI. Conclusion: Our findings suggest an association between specific inflammatory markers and MCI subtypes, highlight sex differences in the association with MCI, and point to a discrete impact of systemic inflammation on cognition.

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Nutrition, Inflammation, and Cognitive Function

Cited by 105 publications

References 127 publications

Cognitive function in COPD

Cognitive function in COPD

Executive Functions Correlated with Body Mass Index in Overweight Middle-Aged Women

Systemic Inflammation Is Associated with MCI and Its Subtypes: The Sydney Memory and Aging Study

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