Nutrition interventions for adults with dyslipidemia: A Clinical Perspective from the National Lipid Association

Kirkpatrick, Carol F.; Sikand, Geeta; Petersen, Kristina S.; Anderson, Cheryl A.M.; Aspry, Karen; Bolick, Julie P.; Kris-Etherton, Penny M.; Maki, Kevin C.

doi:10.1016/j.jacl.2023.05.099

Cited by 37 publications

(9 citation statements)

References 143 publications

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“…Although the LMHR phenotype is typically characterized by low TG levels, it is extremely important to recognize that the intake of large amounts of animal‐derived protein and fat may increase TG levels. Several types of lipids are known to increase LDL‐C or TG levels 5,6 . However, even the same proteins and fats can have significantly different amounts of saturated fatty acids and cholesterol per unit 7–11 .…”

Section: Discussionmentioning

confidence: 99%

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The impact of dietary fat type on lipid profiles in lean mass hyper‐responder phenotype

Takemura,

Inoue,

Matsunaga

et al. 2024

Clinical Case Reports

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Key Clinical MessageAlthough the lean mass hyper‐responder (LMHR) phenotype is well known, its diagnosis is impeded by the influence of fat type and intake on the lipid profile. Accordingly, a detailed assessment is warranted if LMHR is suspected.AbstractA 47‐year‐old man with suspected familial hypercholesterolemia presented with elevated triglyceride and low‐density lipoprotein cholesterol levels. He had adhered to a ketogenic diet and was suspected of a lean mass hyper‐responder phenotype; however, his lipid profile did not meet the definition. His lipid profile improved through dietary management without medication.

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Section: Discussionmentioning

confidence: 99%

“…Several types of lipids are known to increase LDL‐C or TG levels. 5 , 6 However, even the same proteins and fats can have significantly different amounts of saturated fatty acids and cholesterol per unit. 7 , 8 , 9 , 10 , 11 Moreover, the fat content in meats varies according to the anatomical part.…”

Section: Discussionmentioning

confidence: 99%

The impact of dietary fat type on lipid profiles in lean mass hyper‐responder phenotype

Takemura,

Inoue,

Matsunaga

et al. 2024

Clinical Case Reports

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“…The nutritional management of dyslipidemia (including hypercholesterolemia) is mainly based on reducing saturated fat and increasing fiber, unsaturated fatty acids, and plant protein in the diet [35], whereas the role of micronutrients remains less explored. Current evidence suggests that encouraging betaine consumption would favor a beneficial lipid profile and promote cardiovascular health.…”

Section: Discussionmentioning

confidence: 99%

Low Dietary Betaine Intake Is Associated with Increased Blood Cholesterol in Mexican Subjects

Ramos-Lopez,

Santuario-Loera

2024

Healthcare

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Background: Betaine, an osmolyte derivative of the metabolite choline and the amino acid glycine, acts as a methyl donor in the conversion of homocysteine to methionine and is involved in the maintenance of adequate lipid metabolism. There is growing evidence for the role of betaine in the development of various lipid-related diseases, including dyslipidemia and cardiovascular risk. This study aimed to analyze associations between betaine intake and blood lipid profiles in Mexican subjects. Methods: A total of 212 adults were randomly recruited in the city of Tijuana, Baja California, Mexico. Betaine intake was estimated using Nutritionist Pro software. Body composition and metabolic measurements were obtained by conventional methods. In the total sample, the average intake of betaine was 14.32 mg/d. Individuals were categorized into three groups according to tertiles of betaine consumption: tertile/group 1 (<4.16 mg/d), tertile/group 2 (4.16–12.02 mg/d), and tertile/group 3 (>12.02 mg/d). Results: Compared to group 3, subjects within group 1 had higher serum levels of total cholesterol (p = 0.001), LDL-c (p = 0.026), and non-HDL-c (p = 0.021). In addition, significant negative Pearson correlations were found between betaine intake and the serum levels of total cholesterol (r = −0.432, 95% CI, −0.684, −0.185, p = 0.001), LDL-c (r = −0.370, 95% CI, −0.606, −0.134, p = 0.002), and non-HDL-c (r = −0.351, 95%CI, −0.604, −0.098, p = 0.007). Conclusions: Our results show that a low intake of betaine is associated with elevated blood cholesterol levels in Mexican subjects. On this basis, betaine consumption could be used as an additional dietary measure for cardiovascular care. However, additional studies are required to confirm our results in other Mexican regions as well as in other populations worldwide.

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“…Weight loss and improvement of lipid profiles in obese people with dyslipidemia can reduce the risk of hypertension, coronary heart disease and type 2 diabetes mellitus. Conversely, obesity with dyslipidemia if not controlled is at risk of fatty liver which can result in hepatocellular carcinoma (Kirkpatrick et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

Salman,

Hadi,

Ntau

et al. 2023

j. info kesehat.

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Obesity with dyslipidemia is a serious problem because it risks various degenerative and metabolic diseases. The prevalence of obesity in Indonesia continues to increase every year, currently in the adult population reaching 21.8%. To prevent the onset of degenerative diseases and metabolic disorders, it is important to control obesity with dyslipidemia through weight loss and lipid profile improvement. This study aims to determine the effect of nutritional counseling in losing weight and improving lipid profiles in obese patients with dyslipidemia. This is a pseudo-experimental study with One group Pre and Post Test Design. The initial stage was the identification of obesity and lipid profile. In 100 respondents identified as obese, total cholesterol, LDL and triglycerides were examined. 40 obese respondents with dyslipidemia were determined as samples. The second stage was nutrition counseling intervention. The third stage of evaluation is the re-measurement of body weight and lipid profile. The research result is only 30 respondents participated in the evaluation. Average initial body weight was 75.11 kg and final body weight was 73.14 kg. Average weight loss was 1.97 kg. Average initial cholesterol 233.20 mg/dL and final cholesterol 224.70 mg/dL. Average cholesterol reduction of 8.5 mg/dL. Average initial LDL 152.37 mg/dL and final LDL 139.47 mg/dL. Average decrease in LDL 12.9 mg/dL Average initial triglycerides 161.23 mg/dL and final triglycerides 143.97 mg/dL. The average decrease in triglycerides is 17.26 mg/dL. The statistical test results showed a p-value = 0.000. There is an effect of nutritional counseling on weight loss and improvement of lipid profiles of obese patients with dyslipidemia.

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Nutrition interventions for adults with dyslipidemia: A Clinical Perspective from the National Lipid Association

Cited by 37 publications

References 143 publications

The impact of dietary fat type on lipid profiles in lean mass hyper‐responder phenotype

The impact of dietary fat type on lipid profiles in lean mass hyper‐responder phenotype

Low Dietary Betaine Intake Is Associated with Increased Blood Cholesterol in Mexican Subjects

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

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