Nutrition Interventions of Herbal Compounds on Cellular Senescence

Abstract

When cells undergo large-scale senescence, organ aging ensues, resulting in irreversible organ pathology and organismal aging. The study of senescence in cells provides an important avenue to understand the factors that influence aging and can be used as one of the useful tools for examining age-related human diseases. At present, many herbal compounds have shown effects on delaying cell senescence. This review summarizes the main characteristics and mechanisms of cell senescence, age-related diseases, and the recent progress on the natural products targeting cellular senescence, with the aim of providing insights to aid the clinical management of age-related diseases.

Cell Survival, Death, and Proliferation in Senescent and Cancer Cells: the Role of (Poly)phenols

“…[ 74 ] described the potential regulation by (poly)phenols of p53 expression at the transcriptional and posttranslational concentration, especially in (poly)phenol-mediated apoptosis of cancer cells. Different (poly)phenols such as curcumin, resveratrol, and procyanidin C1 exert an antisenescence effect through the modulation of p53/p21cip1 and p16INK4A/Rb tumor suppressor pathways [ [75] , [76] , [77] ].…”

NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity

“…In recent years, there has been growing interest in leveraging the principles of TCM and the therapeutic potential of natural bioactive molecules to address age-related disorders and promote healthy aging. Natural bioactive molecules, derived from plants, herbs, and other natural sources, possess diverse pharmacological properties that can modulate the cellular processes implicated in aging [4][5][6][7], such as oxidative stress [8,9], inflammation [10,11], and cellular senescence [12][13][14].…”