Nutrition, Neurotransmitters and Central Nervous System Fatigue

Davis, J. Mark

doi:10.1002/9780470693766.ch12

Cited by 12 publications

(7 citation statements)

References 50 publications

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“…Nessa situação, seria plausível esperar o comprometimento da produção de força (11,22,23) . Por exemplo, caso ocorra redução da glicemia durante o exercício de endurance, a menor disponibilidade desse substrato poderia afetar o funcionamento do sistema nervoso, atenuando a produção de força (22) .…”

Section: Repmax (70%-1rm)unclassified

Treino de corrida não interfere no desempenho de força de membros superiores

Raddi

Gomes

Charro³

et al. 2008

Rev Bras Med Esporte

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RESUMOObjetivo: O presente estudo avaliou o efeito do exercício de endurance (corrida) sobre o subseqüente desempenho de força de músculos dos membros superiores e do tronco. Metodologia: A amostra foi composta por 13 universitárias, saudáveis e fisicamente ativas. A primeira fase do experimento consistiu na realização de um teste de corrida, simulando uma sessão de treino, com duração de 45 minutos a 70% da FC MAX . Imediatamente após a corrida, foram aplicados testes de força (dinamometria -preensão palmar, teste de 1-RM e teste de repetições máximas a 70%-1RM no supino). A glicemia foi mensurada no início do experimento e imediatamente antes dos testes de força. Resultados: Não foi observada diferença significativa no desempenho dos testes de força após o treino de corrida (dinamometria, 1-RM e REPMAX -sem a prévia execução do treino de corrida -29,9 ± 3,8 kgf; 34,4 ± 3,1 kg; 1 o set: 12,5 ± 3,3 reps e 2 o set: 11,7 ± 2,7 reps vs. com a prévia execução do treino de corrida -29,2 ± 3,1 kgf; 33,9 ± 2,5 kg; 1 o set: 13,2 ± 2,1 reps e 2 o set: 12,2 ± 2,8 reps). Com relação à glicemia, não foi detectada alteração significativa durante o experimento. Conclusão: A execução do treino de corrida não afetou o subseqüente desempenho de força dos membros superiores e do tronco. Esse dado sugere que a interferência, freqüentemente, observada no exercício concorrente, é dependente do grupo muscular treinado. Possivelmente, o efeito adverso induzido pelo treino concorrente, realizado, exclusivamente, com membros inferiores, é decorrente da fadiga residual instalada nos músculos recrutados na atividade anterior. É importante ressaltar que a atividade de endurance não promoveu alteração na concentração plasmática de glicose. A manutenção da glicemia associada à ausência de interferência sobre o desempenho dos testes de força reforça, mais ainda, a hipótese de que o efeito adverso do treinamento concorrente é, provavelmente, causado por alterações periféricas músculo-específicas.Palavras-chave: treinamento concorrente, interferência, endurance, força. ABSTRACTAim: the present study evaluated the effect of endurance exercise (running) on the subsequent strength performance of muscles of upper limbs and trunk. Methodology: Thirteen healthy female, university students, physically active were selected to compose the sample. The first phase of the experiment the subjects were submitted to an endurance exercise bout (treadmill), simulating a training session, with duration of 45 minutes at 70% of the HR max . Immediately after the endurance exercise bout, the subjects performed strength tests (Dynamometry test -handgrip, 1RM test and maximal repetitions test at 70%-1RM in the bench press). Glycemia was measured in the beginning of the experiment and immediately before the strength tests. Results: No significant difference was observed in the strength tests performance after the endurance exercise bout (Dynamometry, 1-RM and REPMAX -with no previous endurance exercise -29.9 ± 3.8 kgf; 34.4 ± 3.1 kg; 1 st set 12.5 ± 3.3 reps and 2 nd ...

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Section: Repmax (70%-1rm)unclassified

Treino de corrida não interfere no desempenho de força de membros superiores

Raddi

Gomes

Charro³

et al. 2008

Rev Bras Med Esporte

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“…Brain catecholamines are known to play a role in arousal, mood, motivation, vigilance, anxiety and reward mechanisms and therefore could, if adversely affected, impair exercise performance (Davis & Bailey, 1997). The depletion of central catecholamine levels has been linked to CNS fatigue by a number of research groups (Chaouloff, 1989; Davis, 2000). A series of animal studies conducted by Davis & Bailey (1997) demonstrated that brain serotonin (5‐HT) and dopamine (DA) activity were elevated during exercise, but a marked fall in tissue DA content was apparent at the point of exhaustion.…”

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confidence: 99%

Influence of brain catecholamines on the development of fatigue in exercising rats in the heat

Hasegawa

Piacentini

Sarre

et al. 2008

The Journal of Physiology

101

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The purpose of the present study was to identify the effects of an acute injection of a dual dopamine (DA)/noradrenaline (NA) reuptake inhibitor (bupropion) on exercise performance, thermoregulation and neurotransmitters in the preoptic area and anterior hypothalamus (PO/AH) of the rat during exercise in the heat. Body core temperature (T core ), brain temperature (T brain ) and tail skin temperature (T tail ) were measured. A microdialysis probe was inserted in the PO/AH, and samples for measurement of extracellular DA, NA and serotonin (5-HT) levels were collected. Rats received either bupropion (17 mg kg −1 ; hot-BUP) or saline (1 ml kg −1 ; hot) 20 min before the start of exercise and ran at a speed of 26 m min −1 until exhaustion in a warm environment (30 • C). Rats also ran until exhaustion in a cool environment (18 • C; cool). Running time to exhaustion was significantly influenced by the ambient temperature, and it was increased by bupropion in the heat (cool, 143.6 ± 21 min; hot, 65.8 ± 13 min; hot-BUP, 86.3 ± 7.2 min). T core and T brain at exhaustion were significantly higher in the bupropion group compared to the cool and hot groups, respectively. T tail measured at exhaustion was not significantly different between the two hot conditions. Extracellular concentrations of DA and NA in the PO/AH increased during exercise, and was significantly higher in the bupropion than in cool and hot groups (P < 0.05). No differences were observed between groups for 5-HT levels. These results suggest that DA and NA in the PO/AH might be responsible for the increase in exercise performance and T core and T brain in the bupropion group in hyperthermia. Moreover, these results support previous findings in humans that acute bupropion ingestion increases T core during exercise in the heat, indicating the possibility of an important role for DA and NA in thermoregulation.

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“…Dopamine (DA) and noradrenaline (NA) have been implicated in arousal, motivation, reinforcement and reward, the control of motor behaviour and mechanisms of addiction (Nestler et al 2001). The depletion of central catecholamines has been linked to CNS fatigue by a number of research groups (Owasoyo et al 1992;Chaouloff, 1989;Davis, 2000). A series of animal studies conducted by Bailey and coworkers (Davis & Bailey, 1997) demonstrated that brain serotonin (5-HT) and DA activity were elevated during exercise, but at the point of exhaustion a marked fall in tissue DA content was apparent.…”

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confidence: 99%

Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions

Watson

Hasegawa

Roelands

et al. 2005

The Journal of Physiology

191

228

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Nine healthy endurance-trained males were recruited to examine the effect of a dual dopamine/noradrenaline reuptake inhibitor on performance, thermoregulation and the hormonal responses to exercise. Subjects performed four trials, ingesting either a placebo (pla) or 2 × 300 mg bupropion (bup), prior to exercise in temperate (18• C) or warm (30 • C) conditions. Trials consisted of 60 min cycle exercise at 55% W max immediately followed by a time trial (TT). TT performance in the heat was significantly improved by bupropion (pla: 39.8 ± 3.9 min, bup: 36.4 ± 5.7 min; P = 0.046), but no difference between treatments was apparent in temperate conditions (pla: 30.6 ± 2.2 min, bup: 30.6 ± 1.9 min; P = 0.954). While TT power output was consistently lower in the heat when compared to temperate conditions, this decrement was attenuated by bupropion. At the end of the TT in the heat, both core temperature (pla 39.7 ± 0.3• C, bup 40.0 ± 0.3 • C; P = 0.017) and HR (pla 178 ± 7 beats min −1 , bup 183 ± 12 beats min −1 ; P = 0.039), were higher in the bupropion trial than in the placebo. Circulating pituitary and adrenal hormone concentrations increased throughout exercise in all trials. Circulating serum prolactin was elevated above temperate levels during exercise in a warm environment (P < 0.001). These data indicate that performance in warm conditions is enhanced by acute administration of a dual dopamine/noradrenaline reuptake inhibitor. No such effect was apparent under temperate conditions. It appears that bupropion enabled subjects to maintain a greater TT power output in the heat with the same perception of effort and thermal stress reported during the placebo trial, despite the attainment of a higher core temperature.

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Nutrition, Neurotransmitters and Central Nervous System Fatigue

Cited by 12 publications

References 50 publications

Treino de corrida não interfere no desempenho de força de membros superiores

Treino de corrida não interfere no desempenho de força de membros superiores

Influence of brain catecholamines on the development of fatigue in exercising rats in the heat

Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions

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