Nutrition, size, and tempo

Hermanussen, Michael; Hermanussen, Michael

doi:10.52905/hbph2022.3.37

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…As pointed out in the introduction section, growth is a dynamic process that is a matter of size but also of tempo (Hermanussen 2010;Mumm et al 2014). Growth, which is defined as an increase in size (amplitude) over time (Hermanussen 2011;Hermanussen and Scheffler 2022), is highly related to developmental tempo, which differs according to genetic as well as environmental factors during childhood. Therefore, we have to distinguish between slow-and fast-maturing children, which differ at the same calendar age not only in their status of maturation but also in growth and therefore in body height (Hermanussen 2011).…”

Section: Discussionmentioning

confidence: 99%

From the fattest to the tallest?

Kirchengast

Hagmann

2023

HBPH

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Background: Growth and finally body height are influenced by various intrinsic and extrinsic factors. During the last decades the well documented secular trend of increase in body height slowed down. Overweight and obesity rates increased worldwide from childhood onwards. An association between rising obesity rates and the slowdown of the secular trend in body height might be assumed. Aims: This study focuses on patterns of associations between childhood weight status, socioenvironmental factors, and adolescent body height. It is hypothesized that higher weight during childhood enhances developmental tempo and linear growth, and results in higher body height during adolescence. Sample and methods: In a longitudinal study, the body height, body weight, and Body mass index (BMI) of 1506 randomly selected Viennese children were documented at the age of six, ten, and fifteen years. Weight status according to sex and age and age-specific BMI percentiles were determined. The association between weight status and body height was analyzed. A history of migration and the socioenvironmental background, based on specific characteristics of the residential area, have been included in the analysis. Results: A marked positive association between weight status during childhood, male sex, socioenvironmental factor, the background of migration, and body height at the age of six and ten years could be documented. At the age of fifteen years, however, only male sex and BMI at age ten years were significantly positively associated with height. Conclusion: High weight or obesity during childhood enhances growth during childhood, but no significant associations between weight status and height were observable during adolescence.

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Section: Discussionmentioning

confidence: 99%

From the fattest to the tallest?

Kirchengast

Hagmann

2023

HBPH

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“…Indeed, mitochondrial activity is associated with several molecular and cellular processes, including gene expression, protein degradation, and neuronal development [10][11][12][13] . At the organismal level, nutrition is well-known to influence growth, and allometric metabolic rates are proposed to underlie diverse growth rates across species 14,15 . Mutants for mitochondrial components also display sluggish development in C. elegans and mice [16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Metabolic activities are selective modulators for individual segmentation clock processes

Matsuda,

Lázaro,

Ebisuya

2024

Preprint

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A sequence of cellular and molecular processes unfolding during embryonic development prompts fundamental questions of how the tempo of multiple processes is coordinated and whether a common global modulator exists. The oscillation of the segmentation clock is a well-studied model of developmental tempo. While the clock period is known to scale with the kinetics of gene expression and degradation processes of the core clock gene Hes7 across mammalian species, how these key molecular processes are coordinated remains unclear. In this study, we investigated if metabolic activities act as a global modulator for the segmentation clock, finding that they are rather selective modulators. While several metabolic inhibitions extended the clock period, their effects on the key processes varied. Inhibition of glycolysis decelerated the protein degradation of Hes7 and extended the production delay but did not influence the intron delay. Electron transport chain inhibition extended Hes7 intron delay without influencing the other two processes. Combinations of distinct metabolic inhibitions exhibited synergistic effects. By contrast, temperature changes affected the clock period and all three key processes simultaneously. These results highlight the selective effects of metabolic activities on segmentation clock processes, hinting that their scaled kinetics across species may be achieved through combinations of multiple modulators.

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“…In this issue, the 10 papers cover a wide range of subjects including growth and the effect of body composition in Sri Lankan children (Wickramasinghe 2022); and the determinants of the resting metabolic rate in Indian children (Areekal et al 2022). It is discussed what stunting tells us (Scheffler and Hermanussen 2022), followed by considerations upon nutrition, size, and tempo (Hermanussen and Scheffler 2022); and the association patterns between childhood obesity and body height during adolescence (Kirchengast and Hagmann 2022). It also addresses diverse topics like the toxic effect of lead on human health (Mandal et al 2022); the assessment of thinness based on BMI and MUAC among the adult Jaunsari (Mukherjee et al 2022); and the impact of television viewing and body fat distribution among the Bengali school children of Kolkata (Sarkar 2022).…”

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confidence: 99%