Nutrition support in hospitalised adults at nutritional risk

Abstract

There is low-quality evidence for the effects of nutrition support on mortality and serious adverse events. Based on the results of our review, it does not appear to lead to a risk ratio reduction of approximately 10% or more in either all-cause mortality or serious adverse events at short-term and long-term follow-up.There is very low-quality evidence for an increase in weight with nutrition support at the end of treatment in hospitalised adults determined to be at nutritional risk. The effects of nutrition support on all remaining outcomes are unclear.Despite the clinically heterogenous population and the high risk of bias of all included trials, our analyses showed limited signs of statistical heterogeneity. Further trials may be warranted, assessing enteral nutrition (tube-feeding) for different patient groups. Future trials ought to be conducted with low risks of systematic errors and low risks of random errors, and they also ought to assess health-related quality of life.

Rationale and developmental methodology for the SIMPLE approach: A Systematised, Interdisciplinary Malnutrition Pathway for impLementation and Evaluation in hospitals

“…Whether acute care clinical dietitians are best placed to resolve the underlying aetiology of malnutrition has been questioned . Malnutrition is a wicked problem .…”

Exploratory and prospective model of stent restenosis after Percutaneous Coronary Intervention using Multivariate Gaussian Subspatial Regression

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Design and rationale of the effect of early nutritional therapy on frailty, functional outcomes and recovery of malnourished medical inpatients trial (EFFORT): a pragmatic, multicenter, randomized-controlled trial

“…Another recent Cochrane review investigating medical and surgical inpatients came to similar conclusions, demonstrating a lack of evidence on the effect of nutritional support on outcome. 10 Both reviews also concluded that previous trials were highly heterogeneous in design, target populations and type of interventions, lacked power to demonstrate safety and in aggregate, thus produced inconclusive results. A very recent trial focusing on a specific protein-rich formula reported no difference in the primary combined adverse event outcome, but found lower mortality in patients receiving the nutritional intervention.…”