Nutritional and lifestyle correlates of the cancer-protective hormone melatonin

Dopfel, Regina; Schulmeister, Karl; Schernhammer, Eva

doi:10.1016/j.cdp.2007.02.001

Cited by 30 publications

(22 citation statements)

References 117 publications

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“…Based on existing knowledge of factors associated with melatonin metabolism,34 40 an initial list of the potential confounders was identified. The list included age, menopausal status (premenopausal for women who reported that they have periods and postmenopausal if reported not having periods), current smoking status, smoking within 24 h before urine collection (yes/no), season of the year of urine collection (March–September vs October–February), alcohol drinking the day before the morning urine spot collection (yes/no), tea and coffee drinking (non-drinker, infrequent drinker—up to six cups per week, and frequent drinker—drinking every day), parity (0, 1, 2, 3+), age at first birth of parous women (<20, 20 to <25, 25 to <30, 30+), age at menarche (≤16, >16 years), age at menopause, chronotype (morning vs evening type), current oral contraceptives or sex hormones use (yes/no) (ever/never), current drugs used (β-blockers, non-steroid anti-inflammatory drugs, diuretics and antidepressants combined into a group as all of them are likely to lower melatonin levels12), quality of sleep index (PSQI) and physical activity (expressed in metabolic equivalents MET hours per week according to the standard IPAQ method).…”

Section: Methodsmentioning

confidence: 99%

Night shift work characteristics and 6-sulfatoxymelatonin (MT6s) in rotating night shift nurses and midwives

et al. 2012

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Objectives Synthesis of melatonin follows a circadian cycle, with high melatonin levels during the night and low levels during the day. Light exposure at night has been hypothesised as one of potential mechanisms of breast carcinogenesis in the night shift workers through inhibition of melatonin synthesis. The aim of the study was to examine a number of determinants for night shift work in relation to 6-sulfatoxymelatonin (MT6s), primary melatonin metabolite. Methods The cross-sectional study included 354 nurses and midwives (aged 40e60 years) currently working on rotating night shifts and 370 working days only. Data from questionnaires and 1-week diaries were used to characterise current job and total occupational history. Associations between rotating night shift work characteristics and MT6s (creatinine adjusted) in spot morning urine were tested in multiple linear regression models.Results No significant differences were found for MT6s concentrations between women currently working on rotating night shifts and those working only day shifts (means 47.2 vs 45.7 ng/mg Cr, respectively). The adjusted means among rotating night shift nurses and midwives varied depending on the department of employment, from 35.1 ng/mg Cr in neonatology to 68.2 ng/mg Cr in the orthopaedics department. Women working eight or more night shifts per month had significantly lower MT6s levels than those having fewer night shifts per month (37.9 vs 47.4 ng/mg Cr, respectively). Total night shift work history was not associated with MT6s. Conclusions The results of this study indicate that working eight or more night shifts per month may disrupt the synthesis of melatonin.

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Section: Methodsmentioning

confidence: 99%

Night shift work characteristics and 6-sulfatoxymelatonin (MT6s) in rotating night shift nurses and midwives

et al. 2012

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“…This decrease in melatonin output has been linked to insomnia [33] and to a higher prevalence of cancer [34][35][36] . The age-related impairment of the immune system is first detected around 60 years of age coinciding with the decrease in plasma melatonin concentration.…”

Section: Basic Physiology Of Melatoninmentioning

confidence: 99%

Melatonin and the Immune System in Aging

Cardinali¹,

Esquifino²,

Srinivasan³

et al. 2008

Neuroimmunomodulation

132

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Aging is associated with a decline in immune function (immunosenescence), a condition known to correlate with increased incidence of cancer as well as infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. Circulating melatonin decreases with age, and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes and macrophages. It also stimulates the production of natural killer cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from natural killer cells and T helper lymphocytes are enhanced by melatonin. Melatonin has the potential therapeutic value to enhance immune function in aged individuals.

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“…Indeed a higher excretion of this metabolite in the first morning urine was 16% higher in women with highest quartile vegetable intake in comparison to the lowest quartile intake (Nagata et al, 2005). Moreover, nutritional and lifestyle have also been correlated with melatonin (Dopfel et al, 2007). A statistically inverse relation among age, smoking and body mass index with urinary 6-sulfatoxymelatonin was found (Schernhmmer and Hankinson, 2005).…”

Section: Influence Of Dietetic Melatoninmentioning

confidence: 92%