Nutritional and Metabolic Consequences of Extensive Bowel Resection

Andersson, Henrik; Bosæus, Ingvar; Brummer, Robert Jan; Fasth, S.; Hultén, L; Magnusson, O.; Strauss, Boyd J G

doi:10.1159/000171149

Cited by 33 publications

(8 citation statements)

References 20 publications

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“…Selenium concentrations had not increased significantly after 3 months of supplementation with n-3 fatty acids andlor AO, which may indicate that more selenium is necessary for the overall protective mechanism of GPx. Fat malabsorption and steatorrhea may also be involved (43), as divalent cations such as selenium, magnesium, or zinc may form unabsorbable subcomplexes (soaps) with malabsorbed fats.…”

Section: Discussionmentioning

confidence: 99%

Nutritional supplementation with N-3 fatty acids and antioxidants in patients with Crohn's disease in remission: Effects on antioxidant status and fatty acid profile

Geerling¹,

Badart‐Smook

Deursen

et al. 2007

Inflamm Bowel Dis

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In patients with Crohn's disease (CD), malnutrition is frequently observed and is generally accepted to be an important issue. The aim of this study was to investigate the effects of 3 months of supplementation with a liquid formula containing either antioxidants (AO) or n-3 fatty acids plus A 0 on the antioxidant status and fatty acid profile of plasma phospholipids and adipose tissue, respectively, in patients with long-standing CD currently in remission. In a randomized, double-blind placebo-controlled study, CD patients received either placebo, AO, or n-3 fatty acids plus A 0 for 3 months in addition to their regular diet. In all, 25/37 CD patients completed the study. A 0 status was assessed by blood biochemical parameters. A statistical per-protocol analysis was performed. Serum concentrations of selenium, vitamin C, and vitamin E, the activity of superoxide dismutase and total antioxidant status were significantly (p < 0.05) increased after A 0 supplementation. Furthermore, compared with controls, serum concentrations of P-carotene, selenium, and vitamin C and the activity of glutathione peroxidase (GPx) were significantly (p < 0.05) lower before supplemention; however, after A 0 supplementation these levels were not significantly different from controls (except for GPx). N-3 fatty acids plus A 0 supplementation significantly (p < 0.05) decreased the proportion of arachidonic acid, and increased the proportion of eicosapentanoic acid and docosahexanoic acid in both plasma phospholipids and adipose tissue. Supplementation with antioxidants improved antioxidant status in patients with CD in remission. In addition, supplementation with n-3 fatty acids plus antioxidants significantly changed the eicosanoid precursor profile, which may lead to the production of eicosanoids with attenuated proinflammatory activity. This study indicates that an immunomodulating formula containing n-3 fatty acids and/or A 0 may have the potential to play a role in the treatment of CD. Key Words:Crohn's disease-Nutritional supplementation-Antioxidants-N-3 fatty acids-Randomized double-blind placebocontrolled trial.

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Section: Discussionmentioning

confidence: 99%

Nutritional supplementation with N-3 fatty acids and antioxidants in patients with Crohn's disease in remission: Effects on antioxidant status and fatty acid profile

Geerling¹,

Badart‐Smook

Deursen

et al. 2007

Inflamm Bowel Dis

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“…SEVERE REDUCTION IN INTESTINAL length results in profound malabsorption leading to malnutrition, dehydration, failure to thrive, and death (3). This condition, known as short bowel syndrome (SBS), is a leading cause of intestinal failure.…”

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confidence: 99%

Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration

Schall

Holoyda

Grant

et al. 2015

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…[5] Most macronutrients are absorbed in the proximal 100–150 cm of intestine. [6] Specific micronutrients are absorbed from specific areas of small intestine.…”

Section: Etiology and Pathophysiologymentioning

confidence: 99%

Short bowel syndrome: A review of management options

Seetharam

Rodrigues

2011

Saudi J Gastroenterol

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Extensive resection of the intestinal tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS). This challenging condition demands a dedicated multidisciplinary team effort to overcome the morbidity and mortality in these patients. With advances in critical care management, more and more patients survive the immediate morbidity of massive intestinal resection to present with SBS. Several therapies, including parenteral nutrition (PN), bowel rehabilitation and surgical procedures to reconstruct bowel have been used in these patients. Novel dietary approaches, pharmacotherapy and timely surgical interventions have all added to the improved outcome in these patients. However, these treatments only partially correct the underlying problem of reduced bowel function and have limited success resulting in 30% to 50% mortality rates. However, increasing experience and encouraging results of intestinal transplantation has added a new dimension to the management of SBS. Literature available on SBS is exhaustive but inconclusive. We conducted a review of scientific literature and electronic media with search terms 'short bowel syndrome, advances in SBS and SBS’ and attempted to give a comprehensive account on this topic with emphasis on the recent advances in its management.

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Nutritional and Metabolic Consequences of Extensive Bowel Resection

Cited by 33 publications

References 20 publications

Nutritional supplementation with N-3 fatty acids and antioxidants in patients with Crohn's disease in remission: Effects on antioxidant status and fatty acid profile

Nutritional supplementation with N-3 fatty acids and antioxidants in patients with Crohn's disease in remission: Effects on antioxidant status and fatty acid profile

Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration

Short bowel syndrome: A review of management options

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