Nutritional and therapeutic potential of Glycyrrhiza glabra L.  roots

Hussain, Fatma; Iqbal, Irum

doi:10.3329/ajmbr.v5i4.45263

“…At a concentration of 100 mg/ml in 50.04%, the methanolic extracts were found to have the maximum antioxidant activity, followed by ethylacetate and chloroform in 34.8 % and 25.16 %, respectively. The biological characteristics of Andrographis paniculata phytocompounds, such as phenolic and flavonoid compounds, are well-known to exhibit a wide range of pharmacological and biological activities, such as antibacterial, hepatoprotective, diuretic, antifungal, anticancer, and antidiabetic effects (Hussain& Iqbal, 2019). Furthermore, flavonoids are polyphenolic compounds with well-known characteristics like scavenging free radicals and inhibiting oxidative and hydrolytic enzymes.…”

Section: Resultsmentioning

confidence: 99%

Analyzing Phytocompounds, Antioxidants, and In-Silico Molecular Docking of Plant-Derived Potential Andrographis paniculata Inhibitory Action to Managed Beta Thalassemia

Khare,

Chatterjee,

Gupta

et al. 2024

MEDIN

0

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It has long been known that medicinal plants are vital to human health and have been used for therapeutic purposes since the beginning of civilization. The goal of this study is to evaluate the scientific data supporting the use of the herbal remedy Andrographis paniculata in the management of beta thalassemia. Phytocompounds, one of the bases of traditional use, were assessed both qualitatively and quantitatively in five different extracts with varying solvent properties (methanol, chloroform, hexane, ethyl acetate, and aqueous), providing the fundamental explanation for the therapeutic relevance of this plant. The presence of flavonoids, phenols, tannins, saponins, and alkaloids in plant extracts was assessed. It was shown that ethanol extract had the highest concentration of phytocompounds among the various extracts, while chloroform extract had the lowest concentration. The plant's antioxidant activity was also assessed, and the results showed that the methanolic extract has potential antioxidant activity, as shown by the DPPH's lowest half-inhibitory concentration (IC50) values. To further evaluate the phytocompounds for their in-silico study, molecular docking techniques were employed. These phytocompounds (DL-alphatocopherol, 3,19-O-diacetylanhdroandrographolide, and 14-acetylandrographolide) to the fetal haemoglobin target protein PDBID:4MQJ were also found to have interactions with significantly minimum binding energies of -12.52 kcal/mol, -11.22 kcal/mol, and -11.08 kcal/mol, where DL-alphatocopherol was found to have the highest binding affinity (-12.524 kcal/mol) and interaction with the active site HIS97. The SwissADME was used to assess the drug-likeness and ADMET characteristics of phytocompounds derived from Andrographis panicluata. Based on chemical characteristics, drug-likeness score, and ADMET model, the present study selected and screened the phytocompounds DL-alphatocopherol, 3,19-O-diacetylanhdroandrographolide, and 14-acetylandrographolide, which are expected to have better drug-like features with improved toxicity profiles. Therefore, it makes sense to send the compounds reported in this work to an in vivo analysis of therapeutic applicability due to their significant biological features.

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“…At a concentration of 100 mg/ml in 50.04%, the methanolic extracts were found to have the maximum antioxidant activity, followed by ethylacetate and chloroform in 34.8 % and 25.16 %, respectively. The biological characteristics of Andrographis paniculata phytocompounds, such as phenolic and flavonoid compounds, are well-known to exhibit a wide range of pharmacological and biological activities, such as antibacterial, hepatoprotective, diuretic, antifungal, anticancer, and antidiabetic effects (Hussain& Iqbal, 2019). Furthermore, flavonoids are polyphenolic compounds with well-known characteristics like scavenging free radicals and inhibiting oxidative and hydrolytic enzymes.…”

Section: Resultsmentioning

confidence: 99%

Analyzing Phytocompounds, Antioxidants, and In-Silico Molecular Docking of Plant-Derived Potential Andrographis Paniculated Inhibitory Action to Managed Beta Thalassemia

Khare,

Chatterjee,

Gupta

et al. 2024

MEDIN

0

View full text Add to dashboard Cite

It has long been known that medicinal plants are vital to human health and have been used for therapeutic purposes since the beginning of civilization. The goal of this study is to evaluate the scientific data supporting the use of the herbal remedy Andrographis paniculata in the management of beta thalassemia. Phytocompounds, one of the bases of traditional use, were assessed both qualitatively and quantitatively in five different extracts with varying solvent properties (methanol, chloroform, hexane, ethyl acetate, and aqueous), providing the fundamental explanation for the therapeutic relevance of this plant. The presence of flavonoids, phenols, tannins, saponins, and alkaloids in plant extracts was assessed. It was shown that ethanol extract had the highest concentration of phytocompounds among the various extracts, while chloroform extract had the lowest concentration. The plant's antioxidant activity was also assessed, and the results showed that the methanolic extract has potential antioxidant activity, as shown by the DPPH's lowest half-inhibitory concentration (IC50) values. To further evaluate the phytocompounds for their in-silico study, molecular docking techniques were employed. These phytocompounds (DL-alphatocopherol, 3,19-O-diacetylanhdroandrographolide, and 14-acetylandrographolide) to the fetal haemoglobin target protein PDBID:4MQJ were also found to have interactions with significantly minimum binding energies of -12.52 kcal/mol, -11.22 kcal/mol, and -11.08 kcal/mol, where DL-alphatocopherol was found to have the highest binding affinity (-12.524 kcal/mol) and interaction with the active site HIS97. The SwissADME was used to assess the drug-likeness and ADMET characteristics of phytocompounds derived from Andrographis panicluata. Based on chemical characteristics, drug-likeness score, and ADMET model, the present study selected and screened the phytocompounds DL-alphatocopherol, 3,19-O-diacetylanhdroandrographolide, and 14-acetylandrographolide, which are expected to have better drug-like features with improved toxicity profiles. Therefore, it makes sense to send the compounds reported in this work to an in vivo analysis of therapeutic applicability due to their significant biological features.

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“…Some plants, such as Lathyrus species, can be considered as ornamental plants (Güneş, 2019). The antioxidant activity of some Fabaceae species such as Lathyrus binatus, Trifolium pannonicum (Gođevac et al, 2008), Glycyrrhiza glabra (Hussein and Iqbal, 2019) was studied.…”

Section: Introductionmentioning

confidence: 99%

DPPH Free Radical Scavenging Activity of Some Fabaceae Lindl. Species

Vergun¹

2020

Agrobiodiversity for Improving Nutrition, Health and Life Quality

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Skif-1 at the flowering stage. Raw material was collected from the experimental collections of M.M. Gryshko National Botanical Garden of the NAS of Ukraine (NBG) in the stage of flowering. Determination of the antioxidant activity of investigated plants conducted by DPPH free radical scavenging activity according to Brand-Williams et al. (1995). The total antioxidant activity of plant whole above-ground part of methanol extracts was from 62.78 (Coronilla varia) to 89.99 (Glycyrrhiza glabra) % and water extracts from 51.28 (Onobrychis grandis) to 90.35 (Lespedeza bicolor) %. Leaf extracts exhibited DPPH scavenging activity in methanol extracts from 63.17 (Trifolium ambiguum) to 93.08 (Onobrychis arenaria) % and water extracts from 57.62 (Coronilla varia) to 95.36 (Lathyrus grandiflorus) %. Stem extracts of investigated plants showed inhibition in methanol extracts from 35.04 (Coronilla varia) to 90.51 (Glycyrrhiza glabra) % and water extracts from 20.35 (Coronilla varia) to 77.52 (Lathyrus grandiflorus) %. DPPH scavenging activity of these plants depended on species and part of plants. Thus, plants from Fabaceae family are a potential source of antioxidant activity that can be used for deep pharmacological investigations for food science.

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Nutritional and therapeutic potential of Glycyrrhiza glabra L. roots

Cited by 3 publications

References 6 publications

Analyzing Phytocompounds, Antioxidants, and In-Silico Molecular Docking of Plant-Derived Potential Andrographis paniculata Inhibitory Action to Managed Beta Thalassemia

Analyzing Phytocompounds, Antioxidants, and In-Silico Molecular Docking of Plant-Derived Potential Andrographis paniculata Inhibitory Action to Managed Beta Thalassemia

Analyzing Phytocompounds, Antioxidants, and In-Silico Molecular Docking of Plant-Derived Potential Andrographis Paniculated Inhibitory Action to Managed Beta Thalassemia

DPPH Free Radical Scavenging Activity of Some Fabaceae Lindl. Species

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