Nutritional care is the first-line therapy for many conditions

Hu, Chunlei; Barazzoni, Rocco; Shi, Hanping

doi:10.1097/pn9.0000000000000059

Cited by 6 publications

(1 citation statement)

References 94 publications

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“…External factors such as lifestyle, nutritional intake, genetic mutations, and heredity all influence the aging process. 11,12 Among these, the relationship between diet and aging has been widely explored. Studies indicate that a high-fat diet can accelerate aging and impair cellular stress recovery capacity.…”

Section: Introductionmentioning

confidence: 99%

Association between dietary quality and accelerated aging: a cross-sectional study of two cohorts

Chen,

Zheng,

Wang

et al. 2024

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Association between dietary quality and accelerated aging: a cross-sectional study of two cohorts

Chen,

Zheng,

Wang

et al. 2024

Food Funct.

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Development and validation of a diagnostic nomogram for frailty in cancer patients

Luo,

Chong,

Huo

et al. 2024

Nutrition

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Association of frailty and malnutrition with overall survival in adults with gastrointestinal cancer: A prospective cohort study

Zheng,

Zhang,

Zhang

et al. 2024

J Nutr Oncol

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Background The mortality burden of patients with gastrointestinal malignancies is increasing worldwide, suggesting the need for more effective prognostic indicators. This study utilized a prospective cohort to (1) analyze the relationship between frailty and malnutrition and their association with the overall survival (OS) in adults with gastrointestinal cancer and (2) explore which specific frailty-related factors most significantly affect the OS. Methods Participants diagnosed with gastrointestinal cancer from 2013 to 2018 who were enrolled in the Investigation on Nutrition Status and Clinical Outcome of Common Cancers study were identified. Malnutrition was determined using the Patient-Generated Subjective Global Assessment, whereas frailty was assessed using the FRAIL scale. The main outcome measured was the all-cause mortality. Multivariable-adjusted logistic regression was used to analyze the cross-sectional link between the nutritional status and frailty. Univariate and multivariate Cox regression analyses were conducted to explore the longitudinal association of these with the OS. Results Among the 4,361 patients enrolled in the study, 1,136 deaths were observed over a median follow-up of 43.4 months. Malnourished patients had a significantly higher risk of frailty than well-nourished patients (OR = 6.25, 95% CI = 5.23–7.51). Frailty and malnutrition independently predicted the OS, with frailty showing an HR of 1.50 (95% CI = 1.33–1.69) and malnutrition showing an HR of 1.51 (95% CI = 1.31–1.74). Patients with both frailty and malnutrition had the highest all-cause mortality risk (HR = 1.82, 95% CI = 1.55–2.14) compared with patients with neither risk factor. Mortality rates rose with the accumulation of additional frailty-related factors. Conclusions Malnutrition and frailty are interrelated prognostic factors in patients with gastrointestinal malignancies, and their simultaneous presence worsens the patient outcomes. Higher scores for resistance and ambulation are major factors associated with a poorer outcome. Future large-scale prospective studies with repeated measurements are necessary to further explore the complex associations among frailty, malnutrition, and the prognosis in patients with gastrointestinal cancer.

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Nutritional care is the first-line therapy for many conditions

Cited by 6 publications

References 94 publications

Association between dietary quality and accelerated aging: a cross-sectional study of two cohorts

Association between dietary quality and accelerated aging: a cross-sectional study of two cohorts

Development and validation of a diagnostic nomogram for frailty in cancer patients

Association of frailty and malnutrition with overall survival in adults with gastrointestinal cancer: A prospective cohort study

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