Nutritional characterization and antioxidant properties of various edible portions of Cucurbita maxima: A potential source of nutraceuticals

Jahan, Farhana; Islam, Md Badrul; Moulick, Shyama Prosad; Bashera, Mahci Al; Hasan, Md Sabbir; Tasnim, Nishat; Saha, Trissa; Boby, Farhana; Waliullah, Md; Saha, Anik; Hossain, Alamgir; Ferdousi, Lailatul; Rahman, Md. Mahmudur; Saha, B. P.; Bhuiyan, Md. Nurul Huda

doi:10.1016/j.heliyon.2023.e16628

Cited by 15 publications

(4 citation statements)

References 46 publications

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“…The present research revealed that the C. maxima leaf had high amounts of carbohydrates, moisture and fibre. It was consistent with the previous study by Jahan et al 25 . Cucurbita maxima's edible sections may aid a person in consuming the appropriate amount of micronutrients daily 26 .…”

Section: Discussionsupporting

confidence: 94%

Preventive and Ameliorative Effects of Diet Supplemented with Cucurbita maxima Leaf on Hyperglycemia and Hepatotoxicity in STZ-Induced Diabetic Rats

Onuche,

Adebisi,

Ikwebe

et al. 2023

Asian J. Biol. Sci

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Background and Objective: Plant materials rich in antioxidant phytochemicals are able to offset the harmful effects of chemicals in the body. The antidiabetic and anti-hepatotoxic effects were investigated in STZ-induced diabetic rats fed a diet supplemented with Cucurbita maxima leaves. Materials and Methods: Sixty rats were randomly assigned into 6 groups of five animals each (n = 5) in preventive and ameliorative trials. Rats were supplemented with 5, 10, 15 and 20% Cucurbita maxima leaf for four weeks. The ANOVA in SPSS version 20 was used to examine the data followed by the Bonferroni multiple comparison (post hoc) Test. Results: Preliminary analysis of Cucurbita maxima leaf powder revealed antioxidant potential, with an IC 50 for DPPH scavenging activity of 3.1 µg mgG 1 . The glucose levels and liver function parameters of the groups whose diets were supplemented with Cucurbita maxima leaf did not show signification (p>0.05) variations as compared to the normal control group in both preventive and ameliorative treatments. Conclusion: In both preventive and ameliorative trials, it can be concluded that the Cucurbita maxima leaves exhibit antihyperglycemic and anti-hepatotoxic effects.

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Section: Discussionsupporting

confidence: 94%

Preventive and Ameliorative Effects of Diet Supplemented with Cucurbita maxima Leaf on Hyperglycemia and Hepatotoxicity in STZ-Induced Diabetic Rats

Onuche,

Adebisi,

Ikwebe

et al. 2023

Asian J. Biol. Sci

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“…The GCMS analysis was performed to identify the active chemicals in various biological processes. Although GCMS analysis of plant root extract has been previously reported [13], the examination of the plant's aerial component was new to this investigation. Phytol was the most abundant component in both the chloroform and methanol extracts, as determined by our research.…”

Section: Discussionmentioning

confidence: 99%

“…Total phenolic content of the extract was determined by the reaction with Folin-Ciocalteau [13]. Gallic acid solution at different concentrations were taken as standard for calibration curve.…”

Section: Total Phenolic Contentmentioning

confidence: 99%

Exploring the Antioxidant and Antiproliferative Properties of Flacourtia indica Extracts on Lung Cancer Cells: A Comprehensive Analysis Utilizing GC-MS, Molecular Docking, and PASS Analysis.

Bashera,

Parvin,

Islam

et al. 2024

Preprint

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Background The study aimed to explore the anti-proliferative potential against a lung cancer cell line for the first time, alongside investigating phytochemical composition, antioxidant activity, and conducting GCMS analysis of Flacourtia indica extracts. This was supplemented by in-silico molecular docking and PASS prediction study for selected compounds. Traditionally decoctions of Flacourtia indica are utilized as anti-helminthic and antibacterial in Bangladesh. Multiple studies have shown its antioxidant, antibacterial, and anti-colorectal cancer effects. Methods The aerial plant was extracted with n-hexane, chloroform, and methanol in order of polarity and the phytoconstituents were determined by GC-MS spectroscopy techniques. MTT assay was used to measure lung cancer cell line viability to determine extract's anti-proliferative effect. The phenolic, flavonoid, antioxidant content analysis was carried out by spectroscopic method. The antineoplastic (breast cancer) potential of selected phytoconstituents were unveiled using the PASS program. Molecular docking analysis further assessed the binding affinity of these bioactive compounds with proteins including topoisomerase II, calvasculin, porin, and TP53. Results GCMS analysis of crude chloroform extract revealed Cyclopropanepentanoic acid, 2-undecyl-, methyl ester (13.072%), phytol (12.667%), benzene,1,2,4-trimethyl, decane, pentadecanoic acid,14-methyl, and 9,12-Octadecanoic acid, methyl ester, and 20 other components. Total phenolics and flavonoids in crude chloroform extract are 2.3882 ± 1.47 mg/gm Gallic acid equivalent and 99.167 ± 32.842 mg/gm quercetin equivalent. The crude chloroform extract (CCE) has antioxidant properties, with IC50 values of 38.691 ± 0.582 µg/mL for DPPH scavenging and 59.81 ± 0.272 µg/mL for iron reducing methods, and 148.75 ± 1.25 mg/gm for catechine antioxidants. The in-silico PASS prediction analysis of the prominent compounds were also carried out against different cell line of lung cancer. The Pa value ranges from 0.502 to 0.639 revealed considerable anti-proliferative activity of the constituents. Compared to tamoxifen as positive control, crude chloroform extract (CCE) inhibited lung-cancer cell proliferation by 22.87%. Molecular docking of discovered chemicals to four proteins supported the anti-carcinogenic theory. Conclusion This comprehensive study provides valuable insights into the anti-carcinogenic potential of Flacourtia indica extracts, particularly against lung cancer cell lines. Further research is warranted to explore its therapeutic potential and pave the way for the development of novel anti-cancer agents derived from natural sources

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“…C. pepo , also known as pumpkin, has been studied for its pharmacological actions. Here are some of the pharmacological activities of C. pepo based on the search results: hepatoprotection, 19 inhibition of benign prostatic hyperplasia, 20 antioxidant, 21 anticancer, 22 antimicrobial, 23 anti-inflammatory, 24 antidiabetic, 25 and antiulcer. 26 This research was conducted to determine whether or not the C. pepo extract has the ability to scavenge free radicals in vitro , as well as its anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

Assessment of In Vitro Antioxidant and Anti-Inflammatory Activities of Pumpkin (Cucurbita pepo) Natural Plant

Fathima,

Firdous,

Pal

et al. 2024

Natural Product Communications

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Objectives The objective of this research was to investigate the potential anti-inflammatory properties of the Cucurbita pepo fruit. Given the adverse effects associated with long-term use or excessive doses of conventional anti-inflammatory medications, exploring herbal therapies as alternatives has become increasingly important. Methods Various preliminary tests and antioxidant assays, both enzymatic and non-enzymatic, were conducted on the C . pepo fruit. Bioactive substances present in the fruit, including alkaloids, carbohydrates, flavonoids, tannins, amino acids, triterpenoids, and saponin glycosides, were identified through early analysis. Different extraction solvents, such as chloroform, methanol, and water, were utilized to extract samples. The methanolic extract was subjected to further testing for its in vitro anti-inflammatory characteristics. This involved evaluating their ability to stabilize RBC membranes, inhibit protein denaturation, and suppress proteinase activity using two concentrations (150 µg/ml and 300 µg/ml) of the extract. Results The methanolic extract of the C. pepo fruit exhibited strong free radical scavenging activity in both DPPH and H2O2 assays. Moreover, it demonstrated the dose-dependent stabilization of RBC membranes, resulting in reduced hemolysis, protein denaturation, and proteinase activity. These findings suggest potent anti-inflammatory effects of the methanolic extract. Conclusion This research study has found that the C. pepo fruit methanolic extract significantly reduced inflammation. This demonstrates the promise of natural chemicals as less risky substitutes for traditional anti-inflammatory medications. Potentially safe and efficient treatments for inflammatory illnesses could be found in herbal remedies such as the C. pepo fruit. Therefore, this study highlights the significance of exploring herbal remedies as a potential treatment option for inflammation-related diseases.

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Nutritional characterization and antioxidant properties of various edible portions of Cucurbita maxima: A potential source of nutraceuticals

Cited by 15 publications

References 46 publications

Preventive and Ameliorative Effects of Diet Supplemented with Cucurbita maxima Leaf on Hyperglycemia and Hepatotoxicity in STZ-Induced Diabetic Rats

Preventive and Ameliorative Effects of Diet Supplemented with Cucurbita maxima Leaf on Hyperglycemia and Hepatotoxicity in STZ-Induced Diabetic Rats

Exploring the Antioxidant and Antiproliferative Properties of Flacourtia indica Extracts on Lung Cancer Cells: A Comprehensive Analysis Utilizing GC-MS, Molecular Docking, and PASS Analysis.

Assessment of In Vitro Antioxidant and Anti-Inflammatory Activities of Pumpkin (Cucurbita pepo) Natural Plant

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