Nutritional control of coronary artery atherosclerosis in the squirrel monkey

Maruffo, Cesar A.; Portman, Oscar W.

doi:10.1016/s0368-1319(68)80060-2

Cited by 48 publications

(8 citation statements)

References 14 publications

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“…The concept of regression gained support with a short-term study in squirrel monkeys by Maruffo and Portman, 15 and more-extensive work by Armstrong and colleagues. The latter reported that advanced arterial lesions in cholesterol-fed Rhesus monkeys underwent shrinkage and remodeling during long-term follow-up when their diet was switched to low-fat or linoleate-rich diets.…”

Section: Plaque Regression-evidence From Animal Studiesmentioning

confidence: 97%

Regression of Atherosclerosis: Insights from Animal and Clinical Studies

Feig

2014

Annals of Global Health

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Based on studies that extend back to the 1920s, regression and stabilization of atherosclerosis in humans has gone from just a dream to one that is achievable. Review of the literature indicates that the successful attempts at regression generally applied robust measures to improve plasma lipoprotein profiles. Examples include extensive lowering of plasma concentrations of atherogenic apolipoprotein B and enhancement of reverse cholesterol transport from atheromata to the liver. Possible mechanisms responsible for lesion shrinkage include decreased retention of atherogenic apolipoprotein B within the arterial wall, efflux of cholesterol and other toxic lipids from plaques, emigration of lesional foam cells out of the arterial wall, and influx of healthy phagocytes that remove necrotic debris as well as other components of the plaque. However, currently available clinical agents cause less dramatic changes in plasma lipoprotein levels, and thereby fail to stop most cardiovascular events. There is, therefore, a clear need for preclinical and clinical testing of new agents expected to facilitate atherosclerosis regression with the hope that additional mechanistic insights will allow further progress.

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Section: Plaque Regression-evidence From Animal Studiesmentioning

confidence: 97%

Regression of Atherosclerosis: Insights from Animal and Clinical Studies

Feig

2014

Annals of Global Health

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“…The concept of regression gained support with a short-term study in squirrel monkeys by Maruffo and Portman (20), and more-extensive work by Armstrong and colleagues. The latter reported that advanced arterial lesions in cholesterol-fed Rhesus monkeys underwent shrinkage and remodeling during long-term follow-up when their diet was switched to low-fat or linoleate-rich diets (21–22).…”

Section: Plaque Regression-evidence From Animal Studiesmentioning

confidence: 98%

The role of HDL in plaque stabilization and regression

Feig

Dangas

2016

Coronary Artery Disease

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Based on studies that extend back to the early 1900s, regression and stabilization of atherosclerosis in humans has gone from a concept to one that is achievable. Successful attempts at regression generally applied robust measures to improve plasma lipoprotein profiles. Possible mechanisms responsible for lesion shrinkage include decreased retention of atherogenic apolipoprotein B within the arterial wall, efflux of cholesterol and other toxic lipids from plaques, emigration of lesional foam cells out of the arterial wall, and influx of healthy phagocytes that remove necrotic debris as well as other components of the plaque. Currently available clinical agents, though, still fail to stop most cardiovascular events. For years, HDL has been considered the “good cholesterol.” Clinical intervention studies to causally link plasma HDL-C levels to decreased progression or to the regression of atherosclerotic plaques, are relatively few because of the lack of therapeutic agents to selectively and potently raise HDL-C. The negative results of studies that were performed have casted uncertainty as to the role HDL possesses in terms of atherosclerosis. It is becoming clearer, though, that HDL function rather than quantity is most crucial and therefore, discovering agents that enhance the quality of HDL should be the goal.

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“…Although other primate species have since supplanted the squirrel monkey in this role, techniques for inducing atherosclerotic plaques in squirrel monkeys by diet manipulation have been well described (Maruffo and Portman 1968;Middleton et al 1967a). A semipurified diet containing 0.1 g/kg of cholesterol with 45% of calories supplied as fat (Maruffo and Portman 1968) was used to induce the lesions in one study. Squirrel monkeys fed atherogenic diets can have a high incidence of gallstones (Osuga and Portman 1971).…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Research Techniques for the Squirrel Monkey (Saimiri sp.)

Brady¹

2000

ILAR Journal

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S quirrel monkeys are useful animal models in a variety of different research disciplines in biomedical research. To properly utilize these animals, it is important that research techniques are properly suited to the unique characteristics of this genus. To consider squirrel monkeys as "miniaturized macaques," or a slightly different version of another animal model, is to underestimate both the potential and the pitfalls of using these animals in research.

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Nutritional control of coronary artery atherosclerosis in the squirrel monkey

Cited by 48 publications

References 14 publications

Regression of Atherosclerosis: Insights from Animal and Clinical Studies

Regression of Atherosclerosis: Insights from Animal and Clinical Studies

The role of HDL in plaque stabilization and regression

Research Techniques for the Squirrel Monkey (Saimiri sp.)

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