Nutritional control of developmental processes

Ferenc, Jaroslav; Ikmi, Aissam

doi:10.1242/dev.200623

Cited by 6 publications

(1 citation statement)

References 75 publications

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“…Although it has been shown that for cultivating embryoids beyond the gastrulation stage in vitro, the precise and timely delivery of oxygen, glucose, and the appropriate culture media in specialized incubators is essential [20], there is no evidence that these factors have any direct instructive function for embryonic pattern (basic body plan) development. They should be seen as nutritional needs in a more general sense [37][38][39]. In earlier years, it had indeed been proposed by some researchers that axis development (the embryonic-abembryonic axis, i.e., the precursor for the dorsoventral axis; the anterior-posterior axis), and the laying down of the basic body plan at gastrulation, might be determined by uterine factors (secreted factors or cellular interactions at implantation).…”

Section: A Recent Discussion About Ethical Guidelines and The Term "E...mentioning

confidence: 99%

Stem Cell-Derived Organoids, Embryoids, and Embryos: Advances in Organismic Development In Vitro Force Us to Re-Focus on Ethical and Legal Aspects of Model Choice

Denker

2023

Organoids

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While research on stem cell-derived tissues and organoids is rapidly expanding, the technically related creation of complex embryoids has recently excited a vivid discussion since it raises ethical questions about individuation and the possible gain of viability. The present study focuses on the onset of organismic development and the proposed biological and legal definitions for the terms embryo, embryoid, and organoid. It is concluded that such considerations have become important for investigators’ choices of the appropriate in vitro model systems, allowing the formation of organoids vs. complex embryoids.

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Section: A Recent Discussion About Ethical Guidelines and The Term "E...mentioning

confidence: 99%

Stem Cell-Derived Organoids, Embryoids, and Embryos: Advances in Organismic Development In Vitro Force Us to Re-Focus on Ethical and Legal Aspects of Model Choice

Denker

2023

Organoids

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Histone dynamics responding to internal and external cues underlying plant development

Cheng,

Wang,

2023

Plant Physiology

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Plants necessitate a refined coordination of growth and development to effectively respond to external triggers for survival and successful reproduction. This intricate harmonization of plant developmental processes and adaptability hinges on significant alterations within their epigenetic landscapes. In this review, we first delve into recent strides made in comprehending underpinning the dynamics of histones, driven by both internal and external cues. We encapsulate the prevailing working models through which cis/trans elements navigate the acquisition and removal of histone modifications, as well as the substitution of histone variants. As we look ahead, we anticipate that delving deeper into the dynamics of epigenetic regulation at the level of individual cells or specific cell types will significantly enrich our comprehension of how plant development unfolds under the influence of internal and external cues. Such exploration holds the potential to provide unprecedented resolution in understanding the orchestration of plant growth and development.

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Metabolic control of germ layer proportions through regulation of Nodal and Wnt signalling

Stapornwongkul,

Hahn,

Palau

et al. 2023

Preprint

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During embryonic development, cells exit pluripotency to give rise to the three germ layers. Metabolic pathways influence cell fate decisions by modulating the epigenetic, transcriptional, and signalling states of cells. However, the interplay between metabolism and the major signalling pathways that drive the emergence of ectoderm, mesoderm, and endoderm remains poorly understood. Here, we demonstrate an instructive role of glycolytic activity in activating signalling pathways involved in mesoderm and endoderm induction. Using an in vitro model system for mouse gastrulation, we observed that inhibiting glycolysis prevents the upregulation of primitive streak markers, resulting in a significant increase in ectodermal cell fates at the expense of mesodermal and endodermal lineages. We demonstrate that this relationship is dose-dependent, enabling metabolic control of germ layer proportions through exogenous glucose levels. Mechanistically, we found that glycolysis inhibition leads to the downregulation of Wnt, Nodal, and Fgf signalling. Notably, this metabolic phenotype was rescued by Nodal or Wnt signalling agonists in the absence of glycolytic activity, suggesting that glycolytic activity acts upstream of both signalling pathways. Our work underscores the dependence of specific signalling pathways on metabolic conditions and provides mechanistic insight into the nutritional regulation of cell fate decision making.

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Nutritional control of developmental processes

Cited by 6 publications

References 75 publications

Stem Cell-Derived Organoids, Embryoids, and Embryos: Advances in Organismic Development In Vitro Force Us to Re-Focus on Ethical and Legal Aspects of Model Choice

Stem Cell-Derived Organoids, Embryoids, and Embryos: Advances in Organismic Development In Vitro Force Us to Re-Focus on Ethical and Legal Aspects of Model Choice

Histone dynamics responding to internal and external cues underlying plant development

Metabolic control of germ layer proportions through regulation of Nodal and Wnt signalling

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