Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis

Calibasi-Kocal, Gizem; Mashinchian, Omid; Başbınar, Yasemin; Ellidokuz, Ender; Cheng, Chia-Wei; Yılmaz, Ömer H.

doi:10.1016/j.tem.2020.11.003

Cited by 30 publications

(20 citation statements)

References 114 publications

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“…On the other hand, high-grain diet, probiotics, prebiotics, and polyphenols could reduce the level of LPS in goat liver ( Chang et al, 2015 ; Fuke et al, 2019 ). In addition, HFD markedly alters the composition of microbiota with enriching the orders Enterobacterales ( Calibasi-Kocal et al, 2021 ). Taken together, these studies suggested HFD-induced increase of Enterobacterales may produce more LPS synthesized by HpeI, and inhibition of HpeI increase and activity could contribute the related diseases.…”

Section: Discussionmentioning

confidence: 99%

Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis

et al. 2021

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Lipopolysaccharide (LPS) is a potent endotoxin on the outer membrane of gram-negative bacteria. Heptosyltransferase I (HpeI) takes part in the synthesis of LPS. In this study, we first collected the protein sequences of HpeI homologs from the human microbiome. The collected HpeI sequences was classified based on sequence similarity, and seven clusters of HpeI were obtained. Among these clusters, proteins from Cluster 3 were abundant in the human mouth, while Clusters 1, 6, and 7 were abundant in the human gut. In addition, proteins from Cluster 1 were mainly from the order of Enterobacterales, while Cluster 6 and 7 were from Burkholderiales. The correlation analysis indicated that the total abundance of HpeIs was increased in patients with cardiovascular disease and liver cirrhosis, and HpeI in Cluster 1 contributed to this increase. These data suggest that HpeI homologs in Cluster 1 can be recognized as biomarkers for cardiovascular disease and liver cirrhosis, and that reducing the bacterial load in Cluster 1 may contribute to disease therapy.

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Section: Discussionmentioning

confidence: 99%

Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis

et al. 2021

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“…Mammalian ISCs are also very responsive to dietary conditions (Calibasi-Kocal et al 2021). In the mouse, ISC regenerative capacity can be determined by the number of intestinal "organoids" (3D structures grown in vitro) generated by the ISC-containing crypts (Sato et al 2009), as well as the ability to regenerate tissue in response to injury in vivo.…”

Section: Environmental Interventions: Dietsmentioning

confidence: 99%

“…Related studies built on these findings by showing that DR-mediated activation of Sirt1 also enhanced proliferation of ISCs and promotes preservation of the "reserve" stem cell pool in an mTOR-dependent manner (Igarashi and Guarente 2016;Yousefi et al 2018). In contrast to DR, fasting does not lead to an increase in ISC number; however, fasting interventions do promote ISC survival and proliferation and progenitor cell function in aged animals and in response to injury, such as exposure to irradiation or chemotherapeutics that cause DNA damage (Richmond et al 2015;Tinkum et al 2015;Mihaylova et al 2018;Calibasi-Kocal et al 2021).…”

Section: Environmental Interventions: Dietsmentioning

confidence: 99%

Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging

Rando

Jones

2021

Cold Spring Harb Perspect Biol

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While some animals, such as planaria and hydra, appear to be capable of seemingly endless cycles of regeneration, most animals experience a gradual decline in fitness and ultimately die. The progressive loss of cell and tissue function, leading to senescence and death, is generally referred to as aging. Adult ("tissue") stem cells maintain tissue homeostasis and facilitate repair; however, age-related changes in stem cell function over time are major contributors to loss of organ function or disease in older individuals. Therefore, considerable effort is being invested in restoring stem cell function to counter degenerative diseases and age-related tissue dysfunction. Here, we will review strategies that could be used to restore stem cell function, including the use of environmental interventions, such as diet and exercise, heterochronic approaches, and cellular reprogramming. Maintaining optimal stem cell function and tissue homeostasis into late life will likely extend the amount of time older adults are able to be independent and lead healthy lives.

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“…We focus on diet−microbiome interactions in this setting, as not only do dietary factors and nutrition have profound effects on the health of host cells, but they also affect the human microbiome [6], which in turn is closely linked to cancer. These observations are especially relevant to the gut: emerging evidence continues to demonstrate that nutritional states directly drive intestinal adaptation, resulting in altered signalling mechanisms within adult intestinal stem cells relevant to intestinal tumour formation [7][8][9][10]. Some correlations to chronic conditions, such as inflammatory diseases, may help inspire future research.…”

Section: Introductionmentioning

confidence: 99%

“…These observations are especially relevant to the gut: emerging evidence continues to demonstrate that nutritional states directly drive intestinal adaptation, resulting in altered signalling mechanisms within adult intestinal stem cells relevant to intestinal tumour formation [ 7 , 8 , 9 , 10 ]. Some correlations to chronic conditions, such as inflammatory diseases, may help inspire future research.…”

Section: Introductionmentioning

confidence: 99%

The Multifaceted Roles of Diet, Microbes, and Metabolites in Cancer

Armstrong

Bording-Jorgensen

Wine

2021

Cancers

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Many studies performed to date have implicated select microbes and dietary factors in a variety of cancers, yet the complexity of both these diseases and the relationship between these factors has limited the ability to translate findings into therapies and preventative guidelines. Here we begin by discussing recently published studies relating to dietary factors, such as vitamins and chemical compounds used as ingredients, and their contribution to cancer development. We further review recent studies, which display evidence of the microbial-diet interaction in the context of cancer. The field continues to advance our understanding of the development of select cancers and how dietary factors are related to the development, prevention, and treatment of these cancers. Finally, we highlight the science available in the discussion of common misconceptions with regards to cancer and diet. We conclude this review with thoughts on where we believe future research should focus in order to provide the greatest impact towards human health and preventative medicine.

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Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis

Cited by 30 publications

References 114 publications

Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis

Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis

Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging

The Multifaceted Roles of Diet, Microbes, and Metabolites in Cancer

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