Nutritional control via Tor signaling in Saccharomyces cerevisiae

Rohde, John R.; Bastidas, Robert J.; Puria, Rekha; Cárdenas, María E.

doi:10.1016/j.mib.2008.02.013

Cited by 118 publications

(115 citation statements)

References 57 publications

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“…The accumulated Brg1 recruits the Hda1 histone deacetylase to promoters of hypha-specific genes, leading to nucleosome repositioning, obstruction of Nrg1 binding sites, and sustained hyphal development (Lu et al 2011(Lu et al , 2012. The conserved Tor1-signaling pathway functions as a global regulator of cellular growth in response to nutrient availability, and it controls different cellular processes in fungi (Rohde and Cardenas 2004;Rohde et al 2008). Therefore, hyphal development is controlled by two major nutrientresponsive and growth-regulating pathways.…”

Section: Environmental Regulation Of Hyphal Morphogenesis Sensing Nutmentioning

confidence: 99%

Fungal Morphogenesis

Lin

Alspaugh

Liu

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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Morphogenesis in fungi is often induced by extracellular factors and executed by fungal genetic factors. Cell surface changes and alterations of the microenvironment often accompany morphogenetic changes in fungi. In this review, we will first discuss the general traits of yeast and hyphal morphotypes and how morphogenesis affects development and adaptation by fungi to their native niches, including host niches. Then we will focus on the molecular machinery responsible for the two most fundamental growth forms, yeast and hyphae. Last, we will describe how fungi incorporate exogenous environmental and host signals together with genetic factors to determine their morphotype and how morphogenesis, in turn, shapes the fungal microenvironment. PROPERTIES OF MORPHOGENESIS IN FUNGAL CELLS

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Section: Environmental Regulation Of Hyphal Morphogenesis Sensing Nutmentioning

confidence: 99%

Fungal Morphogenesis

Lin

Alspaugh

Liu

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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“…4). The addition of rapamycin induces dramatic phenotypic changes such as cell cycle arrest and entry into G 0 , general downregulation of protein synthesis, accumulation of the reserve carbohydrate glycogen and the stress protectant trehalose, upregulation of stress response genes, autophagy and alterations in nitrogen and carbon metabolism (De Virgilio and Loewith 2006a, b;Rohde et al 2008). Hence, it appears that TORC1 signalling controls the temporal aspects of cell growth in response to the quality of the available nitrogen and carbon sources.…”

Section: The Tor Pathwaymentioning

confidence: 99%

“…Hence, it appears that TORC1 signalling controls the temporal aspects of cell growth in response to the quality of the available nitrogen and carbon sources. On the other hand, TORC2, which is insensitive to rapamycin and is less wellcharacterized in comparison to TORC1, is thought to regulate the spatial aspects of growth, such as the control of actin polarization (De Virgilio and Loewith 2006a, b;Rohde et al 2008). Here, we will focus on TORC1, as only this complex modulates nutrient-induced signalling in response to mainly nitrogen sources and to some extent glucose.…”

Section: The Tor Pathwaymentioning

confidence: 99%

Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae

et al. 2010

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Cells of all living organisms contain complex signal transduction networks to ensure that a wide range of physiological properties are properly adapted to the environmental conditions. The fundamental concepts and individual building blocks of these signalling networks are generally well-conserved from yeast to man; yet, the central role that growth factors and hormones play in the regulation of signalling cascades in higher eukaryotes is executed by nutrients in yeast. Several nutrient-controlled pathways, which regulate cell growth and proliferation, metabolism and stress resistance, have been defined in yeast. These pathways are integrated into a signalling network, which ensures that yeast cells enter a quiescent, resting phase (G 0 ) to survive periods of nutrient scarceness and that they rapidly resume growth and cell proliferation when nutrient conditions become favourable again. A series of well-conserved nutrient-sensory protein kinases perform key roles in this signalling network: i.e. Snf1, PKA, Tor1 and Tor2, Sch9 and Pho85-Pho80. In this review, we provide a comprehensive overview on the current understanding of the signalling processes mediated via these kinases with a particular focus on how these individual pathways converge to signalling networks that ultimately ensure the dynamic translation of extracellular nutrient signals into appropriate physiological responses.

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“…9, 14, and reviewed in ref. 15). In particular, the class C Vps complex was proposed to provide amino acid homeostasis for efficient Tor signaling (14).…”

mentioning

confidence: 99%

Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae

Puria

Zurita-Martinez

Cárdenas

2008

Proc. Natl. Acad. Sci. U.S.A.

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The yeast Saccharomyces cerevisiae has developed specialized mechanisms that enable growth on suboptimal nitrogen sources. Exposure of yeast cells to poor nitrogen sources or treatment with the Tor kinase inhibitor rapamycin elicits activation of Gln3 and transcription of nitrogen catabolite-repressed (NCR) genes whose products function in scavenging and metabolizing nitrogen. Here, we show that mutations in class C and D Vps components, which mediate Golgi-to-endosome vesicle transport, impair nuclear translocation of Gln3, NCR gene activation, and growth in poor nitrogen sources. In nutrient-replete conditions, a significant fraction of Gln3 is peripherally associated with light membranes and partially colocalizes with Vps10-containing foci. These results reveal a role for Golgi-to-endosome vesicular trafficking in TORC1-controlled nuclear translocation of Gln3 and support a model in which Tor-mediated signaling in response to nutrient cues occurs in these compartments. These findings have important implications for nutrient sensing and growth control via mTor pathways in metazoans.rapamycin action ͉ Tor signaling

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Nutritional control via Tor signaling in Saccharomyces cerevisiae

Cited by 118 publications

References 57 publications

Fungal Morphogenesis

Fungal Morphogenesis

Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae

Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae

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