Nutritional Decline in Scleroderma Patients Data from a single Romanian center

Burlui, Alexandra; Graur, Mariana; Constantinescu, Daniela; Cardoneanu, Anca; Macovei, Luana Andreea; Rezuş, Elena

doi:10.37358/rc.18.5.6308

Cited by 2 publications

(2 citation statements)

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“…Importantly, malnutrition was found to increase the risk of mortality in the general population as well as in patients with scleroderma. These results raise the issue of providing effective strategies for the prevention of weight loss and malnutrition in SSc [8,86,87]. Through intricate mechanisms, chronic systemic diseases are often associated with nutritional status alterations [88][89][90][91].…”

Section: Discussionmentioning

confidence: 99%

Diet in Scleroderma: Is There a Need for Intervention?

et al. 2021

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Systemic sclerosis (SSc) patients exhibit a plethora of risk factors for nutritional decline, including the presence of chronic inflammation and the progressive nature of disease-related multisystem involvement. The prevalence and consequences of nutritional decline in scleroderma are frequently underestimated, its management currently remaining a subject of debate. The main objective of the present study was to perform a detailed assessment of scleroderma patients’ diet as well as their eating habits and to describe the relationships with weight loss and malnutrition risk in the absence of professional nutritional counseling. Methods: We used a translated and validated version of the EPIC-Norfolk FFQ (European Prospective Investigation into Cancer and Nutrition Norfolk Food Frequency Questionnaire) to evaluate the patients’ diet and MUST (Malnutrition Universal Screening Tool) to investigate the risk of malnutrition. Disease activity was estimated using the EUSTAR-AI (European Scleroderma Trials and Research group Activity Index). Results: We included 69 patients with SSc, of which 42 underwent a detailed dietary assessment. Dietary factors were connected to body composition and digestive symptoms. We found high sodium intake and frequent suboptimal energy consumption in our study group, including patients with cardiopulmonary involvement. Liver transaminases were inversely correlated with the consumption of nuts and seeds. Malnutrition and weight loss were significantly associated with pulmonary hypertension, heart failure, albumin levels, and the extent of skin fibrosis, but not advanced age. Although the patients with EUSTAR-AI ≥ 2.5 were more frequently included in the moderate and high malnutrition risk categories, these results did not reach statistical significance. Conclusions: Currently, there is an unmet need for longitudinal and interventional research focusing on the long-term significance, ramifications, and management of nutritional impairment in SSc patients with various clinical manifestations. Our results indicate that scleroderma patients could benefit from personalized nutritional counseling in an interdisciplinary setting.

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Section: Discussionmentioning

confidence: 99%

Diet in Scleroderma: Is There a Need for Intervention?

et al. 2021

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“…Intoxication with alcohol, chloroform, ether causes the increase in lipoids in the blood (cholesterol and phosphatides). At the base of the lipemia pathogenesis, there is often a disorder of the transport of fat from the fat deposits in the organs and vice versa (transport lipemia), as well as the delayed passage of blood lipids into the organs or the retention of lipids in the blood (retentive lipemia) (in anemia) [1][2][3][4].…”

Section: Resorption and Fat Depositing Disordersmentioning

confidence: 99%

Biological Chemistry in Intermediate Lipid Metabolism Disorder

Condratovici¹,

Elisei²,

Vasincu³

et al. 2019

Rev. Chim.

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Any pathological process is accompanied by quantitative and qualitative changes in metabolism, which is the main form of life manifestation. Metabolism disorders (it is the permanent exchange of substances between the body and the environment) arise if the activity of the central nervous system is affected; the trophic function of the nervous system directs nutrition and metabolism. In this function, the coordinating role belongs to the central nervous system and is made by means of the endocrine glands. Lipids introduced into the body are digested mainly with the help of the pancreatic and intestinal juice and are resorbed through the walls of the small intestine. Even in the intestinal wall, the re-synthesis of fatty acids and glycerine fat occurs. A certain amount of neutral fat is probably resorbed without being split into fatty acids and glycerine. Fats are mainly resorbed through the lymphatic system, in part (about 30%) by means of the portal vein system; the entire fat emulsion penetrates into the blood and its main mass is deposited in certain fat deposits: the adipose subcutaneous cell tissue, the epiploon and the mesenterium of the abdominal cavity, as well as in the fatty layers of the various organs. In fat deposits, processes of lipid formation from carbohydrates and of transformation of higher fatty acids can occur. Lipids from fat deposits are subject to oxidation, especially at the liver level.

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Nutritional Decline in Scleroderma Patients Data from a single Romanian center

Cited by 2 publications

References 18 publications

Diet in Scleroderma: Is There a Need for Intervention?

Diet in Scleroderma: Is There a Need for Intervention?

Biological Chemistry in Intermediate Lipid Metabolism Disorder

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