Nutritional deficiencies in patients with Crohnʼs disease in remission

Filippi, Jérôme; Al-Jaouni, Rima; Wiroth, Jean-Baptiste; Hébuterne, Xavier; Schneider, S.

doi:10.1097/01.mib.0000206541.15963.c3

Cited by 222 publications

(270 citation statements)

References 46 publications

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“…Essa semelhança na composição corporal entre pacientes com DC (n=94) e RCUI (n=50) em remissão persistiu quando o número de pacientes avaliados foi maior, em que também não houve diferença na gordura corporal (kg) entre os grupos 28 . No estudo com 54 pacientes com DC em remissão clínica há pelo menos três meses apresentaram gordura corporal (kg) menor que os controles saudáveis, sem diferença em outros parâmetros como peso e massa livre de gordura 8 .…”

Section: Discussionunclassified

Relação entre estado nutricional e atividade inflamatória em pacientes com doença inflamatória intestinal

Silva

Schieferdecker

Rocco

et al. 2010

ABCD, arq. bras. cir. dig.

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DESCRITORES -Doença InflamatóriaIntestinal. Avaliação nutricional. Obesidade. ABSTRACT -Background -The inflammatory bowel diseases are characterized by multiple digestive tract symptoms and therefore may interfere with nutritional status. Aim -To assess the nutritional status of patients with inflammatory bowel disease in different stages of inflammatory activity. Methods -Fifty five patients with inflammatory bowel disease were demographically evaluated with weight measurement, height, arm circumference and triceps skinfold and had their body composition determined by bioelectrical impedance. For determination of inflammatory activity of the disease were used serum C-reactive protein and the index of Harvey and Bradshaw. To compare means it was used the unpaired t test, and the average non-parametric, the Mann-Whitney test, level of significance p <0.05. Results -Among the patients, 28 had Crohn's disease and 27 ulcerative colitis, aged between 19 and 63 years and time since diagnosis 1-22 years. There was no difference in anthropometric measurements and body composition of patients whose disease was inflammatory activity or in remission. Patients who used glucocorticoids in the six months preceding the assessment showed body fat percentage of 23.4 ± 8.2% whilst those who did not use the percentage was 30.7 ± 11.3 (p <0.0199). The most common gastrointestinal symptoms were abdominal distension (41%), diarrhea (18%), nausea (13%), constipation (12%), anorexia (11%) and vomiting (5%). All symptoms were more common in patients with higher body mass index and body fat. Conclusion -There were more patients with excess weight and body fat, and these patients were more symptomatic and had higher values of C-reactive protein. RESUMO -Racional

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Section: Discussionunclassified

Relação entre estado nutricional e atividade inflamatória em pacientes com doença inflamatória intestinal

Silva

Schieferdecker

Rocco

et al. 2010

ABCD, arq. bras. cir. dig.

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“…Despite being low, dietary intakes in Crohn's disease are comparable with population intakes (29,37,38) . Poor dietary intakes may also be hindered by reduced absorption.…”

Section: Factors Influencing Vitamin D Levels In Crohn's Diseasementioning

confidence: 95%

Optimal vitamin D levels in Crohn's disease: a review

Raftery

O’Sullivan

2014

Proc. Nutr. Soc.

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Vitamin D deficiency is common among patients with Crohn's disease. Serum 25-hydroxyvitamin D (25(OH)D) is the best measure of an individual's vitamin D status and current cut-off ranges for sufficiency are debatable. Several factors contribute to vitamin D deficiency in Crohn's disease. These include inadequate exposure to sunlight, inadequate dietary intake, impaired conversion of vitamin D to its active metabolite, increased catabolism, increased excretion and genetic variants in vitamin D hydroxylation and transport. The effects of low 25(OH)D on outcomes other than bone health are understudied in Crohn's disease. The aim of the present review is to discuss the potential roles of vitamin D and the possible levels required to achieve them. Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention. The present literature appears to suggest that 25(OH)D concentrations of ≥75 nmol/l may be required for non-skeletal effects; however, further research on optimal levels is required.

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“…Studies have found that indirect calorimetry in relation to resting energy expenditure in patients with IBD in remission showed no difference compared with healthy controls 9 . The same was observed in active CD patients without steroids 30 , but activity in patients in remission and who received corticosteroids had higher resting energy expenditure than controls 2 .…”

Section: Discussionmentioning

confidence: 99%

Ingestão alimentar em pacientes com doença inflamatória intestinal

Silva¹,

Schieferdecker²,

Amarante³

2011

ABCD, arq. bras. cir. dig.

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-Background -Patients with inflammatory bowel disease may have nutritional deficiencies. Aim -To verify the adequacy of dietary intake of patients with Crohn's disease and ulcerative colitis. Methods -To assess food intake of 55 patients, 28 with Crohn's disease and 27 with ulcerative colitis treated in the gastroenterology clinic, was used the 24-Hour Food Recall and Food Frequency Questionnaire. The inflammatory activity of the disease was evaluated by serum C-reactive protein and Harvey and Bradshaw Index. For comparison of means t test was used, and the average on non-parametric, the Mann-Whitney test, with level of significance p <0.05. Results -The patients were aged between 19 and 63 years and time since diagnosis was 7.9 years (1 to 22). According to the food intake was identified deficiency in energy intake, fiber, iron, potassium, sodium, magnesium, calcium, menadione, riboflavin, niacin, folate, pantothenic acid, tocopherol and cholecalciferol in Crohn's disease and ulcerative colitis, active or in remission. The intake of vegetables, fruits, dairy products and beans were low, and intake of fats and sweets was higher than the recommendations. Conclusion -There was a deficiency in food intake both in Crohn's disease and in ulcerative colitis, in activity and in remission. These deficiencies can adversely affect the disease course, and justify the need for nutritional intervention with these patients. ABCDDV/794RESUMO -Racional -Pacientes com doença inflamatória intestinal podem apresentar deficiências nutricionais. Objetivo -Verificar a adequação da ingestão alimentar de pacientes com doença de Crohn e retocolite ulcerativa inespecífica. Métodos -Para avaliação da ingestão alimentar de 55 pacientes, 28 com doença de Crohn e 27 com retocolite ulcerativa atendidos em ambulatório de gastroenterologia, utilizou-se o Recordatório Alimentar de 24 Horas e o Questionário de Frequência Alimentar. A atividade inflamatória da doença foi avaliada pelos níveis séricos de proteína C reativa e o Índice de Harvey e Bradshaw. Para comparação de médias foi usado o teste t não pareado e, para as médias não paramétricas, o teste de Mann-Whitney, considerando nível de significância valor de p<0,05. Resultados -Os pacientes tinham idade entre 19 e 63 anos e tempo de diagnóstico de 7,9 anos (1 a 22). De acordo com a ingestão alimentar identificou-se deficiência na ingestão de energia, fibras, ferro, potássio, sódio, magnésio, cálcio, menadiona, riboflavina, niacina, folato, ácido pantotênico, tocoferol e colecalciferol na doença de Crohn e na retocolite ulcerativa em atividade ou em remissão. A ingestão de legumes, frutas, laticínios e feijão foi baixa, e a de doces e gorduras foi maior que as recomendações. Conclusão -Houve deficiência na ingestão alimentar tanto na doença de Crohn como na retocolite ulcerativa, em atividade e em remissão. Essas deficiências podem afetar negativamente o curso da doença e justificam a necessidade de intervenção nutricional com esses pacientes.

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Nutritional deficiencies in patients with Crohnʼs disease in remission

Abstract: In CD patients in remission, macronutrient needs are usually covered by food intake. However, micronutrient deficiencies are frequent and call for specific screening and treatment.

Cited by 222 publications

References 46 publications

Relação entre estado nutricional e atividade inflamatória em pacientes com doença inflamatória intestinal

Relação entre estado nutricional e atividade inflamatória em pacientes com doença inflamatória intestinal

Optimal vitamin D levels in Crohn's disease: a review

Ingestão alimentar em pacientes com doença inflamatória intestinal

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